In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
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| Number | Title | Issue Date |
| 6245531 | Polynucleotide encoding insect ecdysone receptor Polynucleotide sequences which encode ecdysone receptors have been isolated and expressed in host cells.... | 06/12/2001 |
| 6192143 | Apparatus for detecting very small breast anomalies A computer controlled apparatus for detecting breast tumors by mechanically palpating in a full surface scan manner to detect even very small lumps or other anomalies. The patient is positioned on a fully adjustable bed and oriented relative the apparatus... | 02/20/2001 |
| 6153741 | DNA methylation gene from plants A novel gene, DDM1, and its encoded protein are provided. The gene was isolated from a region of Arabidopsis thaliana chromosome 5. DDM1 appears to be part of the SWI2/SNF2 family of chromatin-remodeling proteins. Disruption of the gene results in DNA hyp... | 11/28/2000 |
| 6150171 | Thermostable alpha-galactosidase and methods of use An isolated nucleic acid from the bacterium Thermotoga neapolitana, encoding a thermostable -galactosidase is provided. The Thermotoga gene is cloned into a high expression vector to provide large quantities of a purified thermostable -galac... | 11/21/2000 |
| 6136605 | Glutathione S-transferase isoforms A method is described for the creation of novel isoforms of the enzyme glutathione S-transferase which have enhanced activity in host cells against specific toxic agents. The method includes site directed mutagenesis and selection with the targeted agent ... | 10/24/2000 |