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| Number | Title | Issue Date |
| 4814744 | Low tire-pressure warning system A method and apparatus for detecting low air pressure in pneumatic tires on a vehicle and conveying this information to the operator of the vehicle. The invention utilizes a resonating device which creates subsonic, sonic, or ultrasonic air waves when it ... | 03/21/1989 |
| 4629792 | Chromatographic separation of tropicamide O-ଲ-D-glucuronide diastereomers An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-ଲ-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-ଲ-D-glucuronide a... | 12/16/1986 |
| 4588686 | Enzymatic process for preparing glucuronides An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-ଲ-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-ଲ-D-glucuronide a... | 05/13/1986 |
| 4574083 | Isolates of pythium species which are antagonistic to Pythium ultimum Novel isolates of Pythium are provided which are antagonistic to indigenous plant pathogenic species of Pythium ultimum from soil. The isolates suppress the growth of P. ultimum when added to soil and are particularly useful to protect seedlings from damp... | 03/04/1986 |
| 4548814 | Composition of matter and process Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environme... | 10/22/1985 |
| 4546096 | Anticholinergic glucuronides and antiperspirant use thereof This invention concerns novel and useful human antiperspirant compounds which are glucuronides of phenolic anticholinergics or the phenolic derivatives of anticholinergic compounds. These antiperspirant compounds, advantageously, do not have mydriatic pro... | 10/08/1985 |
| 4520191 | Paulomycin derivatives Novel and useful compounds are obtained by the degradation of antibiotics paulomycin A and paulomycin B. These novel compounds are useful as ultraviolet light filters in plastics, cloth, and the like.... | 05/28/1985 |
| 4518691 | In vitro enzymatic process for preparing glucuronides of ester-containing anticholinergics An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.... | 05/21/1985 |
| 4515773 | Skin tanning composition and method The subject invention concerns a novel, unobvious, and useful composition of matter and method for tanning the human epidermis. The composition comprises a suitable dye precursor and tyrosinase. These ingredients, when reacted together on the skin, result... | 05/07/1985 |
| 4505895 | Antibiotic 273a1 Novel and useful antibiotics designated 273a1.spsb. and 273a1.spsb.ଲ can be produced in a fermentation using Streptomyces paulus, strain 273, NRRL 12251. These antibiotics are active against various Gram-positive bacter... | 03/19/1985 |
| 4486414 | Dolastatins A and B cell growth inhibitory substances Potent cell growth inhibitory substances have been obtained from the Indian Ocean sea hare Dolabella. These substances have been given the names dolastatin A and dolastatin B. These compounds are characterized by physical and chemical parameters.... | 12/04/1984 |
| 4478936 | In vitro enzymatic process for producing glucuronides An in vitro enzymatic process for preparing O-ଲ-D-glucuronides which comprises reacting a solution of D-glucuronic acid with a solution of a compound which has a primary alcohol, and a solution of ଲ-glucuronidase for a time sufficient to form ... | 10/23/1984 |
| 4476300 | N-Oxide of the O-ଲ-D glucuronides of anticholinergic compounds, and process for preparing the same The subject invention concerns a novel process for preparing novel N-oxide compounds of O-ଲ-D-glucuronides of an anticholinergic compound containing a tertiary nitrogen. Examples of suitable glucuronide starting materials are O-ଲ-D-glucuronide... | 10/09/1984 |
| 4471111 | Glucuronides of ester-containing anti-cholinergics An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.... | 09/11/1984 |
| 4464466 | Process of producing lincomycin nucleotides Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo.... | 08/07/1984 |
| 4454228 | Biologically pure culture of Streptomyces microspinus NRRL 12524 capable of producing antibiotic U-64,815 Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, ... | 06/12/1984 |
| 4448970 | Nargenicin derivatives Novel antibacterially-active analogs of the antibiotics nodusmicin and nargenicin A1. These compounds are prepared by selectively blocking active hydroxyl groups at the 9, 11 and 18 positions of nodusmicin, and the 11 and 18 positions of nargen... | 05/15/1984 |
| 4443539 | Process for preparing bovine growth hormone A process for expression of the gene for bovine growth hormone in the yeast Saccharomyces cerevisiae. Bovine growth hormone can be used to increase milk production in cows.... | 04/17/1984 |
| 4443608 | (+),(-)-Tropicamide O-ଲ-B-glucuronic acid, its diastereomers, and salts thereof An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-ଲ-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-ଲ-D-glucuronide a... | 04/17/1984 |
| 4431820 | 6-Methoxy indoline acetate and its 5-nitro and 5-amino derivatives Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacte... | 02/14/1984 |
| 4431591 | 24-Nor-1,4-choladiene-3,22-dione The subject invention concerns a novel fermentation process for making the useful steroid intermediate 24-nor-1,4-choladiene-3,22-dione (I). Compound (I) can be converted to valuable corticoids by known methods.... | 02/14/1984 |
| 4430495 | Process for preparing lincomycin and clindamycin ribonucleotides Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo. These ribonucleotides are prepa... | 02/07/1984 |
| 4430428 | Composition of matter and process A process for expression of a gene, foreign to the host organism, coding for a protein in a suitable vehicle which comprises taking said gene and fusing it in the correct orientation relative to a transcriptional initiation region present in said vehicle,... | 02/07/1984 |
| 4429041 | Process of producing 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid The subject invention concerns a novel one-stage fermentation process for making the useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid (I). This process is significantly superior to the best prior art process known for ma... | 01/31/1984 |
| 4427776 | Composition of matter and process Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, ... | 01/24/1984 |
| 4425429 | Composition of matter and process The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.... | 01/10/1984 |
| 4424365 | 1,2,8,8a-Cyclopropa[c]benzo[1,2,-b:-4,3-b']dipyrrol-4(5H)-ones Novel antibacterially active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bact... | 01/03/1984 |
| 4423146 | Composition of matter and process The subject invention concerns a novel fermentation process for making the useful steroid intermediate 24-nor-1,4-choladiene-3,22-dione (I). Compound (I) can be converted to valuable corticoids by known methods.... | 12/27/1983 |
| 4423228 | Process for preparing N-(methyl-sulfonyl)-1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4( 5H)-one Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacte... | 12/27/1983 |
| 4423230 | Preparation of an intermediate for N-(methylsulfonyl)-1,2,8,8a-cyclopropa[c][1,2-b:-4,3-b']dipyrol-4(5H)-on e Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacte... | 12/27/1983 |
| 4423229 | Composition of matter and process Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[ c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bac... | 12/27/1983 |
| 4414205 | Cell growth inhibitory substances Potent cell growth inhibitory substances have been obtained from the Indian Ocean sea hare Dolabella. These substances have been given the names dolastatin 1, dolastatin 2, and dolastatin 3. These compounds are characterized by physical and chemical param... | 11/08/1983 |
| 4413132 | Antibiotic CC-1065 indoline intermediates Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bact... | 11/01/1983 |
| 4405525 | Composition of matter and process The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.... | 09/20/1983 |
| 4404190 | Composition of matter and process Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, fo... | 09/13/1983 |
| 4401761 | Process for stabilizing plasmids by deletion of DNA Novel chemical compounds, recombinant plasmids pUC1026 and pUC1027, which are obtained by covalent linkage of the E. coli plasmid pBR322 to the Streptomyces espinosus plasmid pUC6. These plasmids are produced by a novel process which can be used to stabil... | 08/30/1983 |
| 4400518 | Composition of matter and process Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacte... | 08/23/1983 |
| 4397950 | Process for production of antibiotic U-64,767 using Streptomyces macronensis NRRL 12566 Novel antibiotic U-64,767 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces macronensis Dietz sp.n., NRRL 12566. This antibiotic is active against various Gram-positive bacteria, f... | 08/09/1983 |
| 4397845 | Lincomycin 3-(5'-adenylate) as anesthetic The 3-(5'-adenylate) of lincomycin- and clindamycin-type compounds in which the propyl hygric acid moiety has been replaced by different cyclic amino acids can be used as a local anesthetic in humans and animals.... | 08/09/1983 |
| 4393137 | Cloning plasmid for streptomyces Novel chemical compound plasmid pUC1061 obtained by deletion of ~2.0 kilobases of DNA from the Streptomyces espinosus plasmid pUC6. This plasmid is useful as a cloning vehicle in recombinant DNA work. For example, using DNA methodology, a desired gene, fo... | 07/12/1983 |
