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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 5843984 | Sulfated benzothiophene derivatives, methods of use and formulations containing same Sulfated benzothiophenes of the formula I ##STR1## wherein R1 is hydrogen, hydroxy, C1 -C4 alkoxy, --OCOO(C1 -C6 alkyl), --OCO(C1 -C6 alkyl), --OCOAr wherein Ar is phenyl or... | 12/01/1998 |
| 5843974 | Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se A method of inhibiting melanoma comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, ##STR2## wherein Ar is optional... | 12/01/1998 |
| 5843964 | Methods of inhibiting endometrial mitoses A method of inhibiting endometrial mitoses comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, --CH3, ##STR2#... | 12/01/1998 |
| 5827844 | Lipophilic benzothiophenes used for treating endometriosis The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R1 is N-pyrrolidinyl or N-piperidinyl; R2 and R3 are independently hydrogen, --CO--(C10 -C22 alkyl), --CO--(C | 10/27/1998 |
| 5811437 | Methods of increasing nitric oxide synthesis The current invention provides methods for increasing the concentration of nitric oxide (NO) in vascular endothelial cells, comprising administering a compound of formula I ##STR1## Wherein: R is hydrogen, --OH, --O(C1 -C4 alkyl... | 09/22/1998 |
| 5811415 | Lipophilic benzothiophenes The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R1 is N-pyrrolidinyl or N-piperidinyl; R2 and R3 are independently hydrogen, --CO--(C10 -C22 alkyl), --CO--(C | 09/22/1998 |
| 5789400 | Lipophilic benzothiophenes The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R1 is N-pyrrolidinyl or N-piperidinyl; R2 and R3 are independently hydrogen, --CO--(C10 -C22 alkyl), --CO--(C10 | 08/04/1998 |
| 5780648 | Benzothiophene compounds, and uses formulations thereof Benzothiophenes, and uses and formulations thereof, are provided by the present invention.... | 07/14/1998 |
| 5731342 | Benzothiophenes, formulations containing same, and methods This invention provides novel benzothiophene compounds.... | 03/24/1998 |
| 5731328 | Methods of inhibiting plasminogen activator inhibitor 1 A method of inhibiting plasminogen activator inhibitor 1 comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, --CH3... | 03/24/1998 |
| 5726168 | Lipophilic benzothiophenes The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R1 is N-pyrrolidinyl or N-piperidinyl; R2 and R3 are independently hydrogen, --CO--(C10 -C22 alkyl), --CO--(C10 | 03/10/1998 |
| 5691355 | Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs The present invention provides a method of minimizing the uterotrophic effect of non-steroidal antiestrogen compounds of formula II ##STR1## wherein either R4 is H or a lower alkyl radical and R5 is a lower alkyl radical, or R | 11/25/1997 |
| 5670523 | Methods of inhibiting musculoaponeurotic fibromatoses (desmoid tumors) A method of inhibiting musculoaponeurotic fibromatoses comprising administering to a mammal in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, ##STR2#... | 09/23/1997 |
| 5670514 | Compositions for inhibiting bone loss The present invention provides methods of inhibiting bone loss in mammals via the administration to a mammal in need of such treatment an effective amount of a compound from a series of benzoquinolin-3-ones. Such compounds also are sequentially or concurr... | 09/23/1997 |
| 5643896 | 2-Benzyl-3-arylbenzothiophenes The present invention provides a compound of formula I ##STR1## wherein R1 is hydrogen, a hydroxy protecting group, or methyl; R2 and R3 are independently C1 -C6 alkyl, or R2 and R3 | 07/01/1997 |
| 5622975 | Methods for inhibiting vascular smooth muscle cell migration Methods of inhibiting vascular smooth muscle cell migration comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independent... | 04/22/1997 |
| 5604248 | Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs The present invention provides a method of minimizing the uterotrophic effect of non-steroidal antiestrogen compounds of formula II ##STR1## wherein either R4 is H or a lower alkyl radical and R5 is a lower alkyl radical, or R | 02/18/1997 |
| 5599822 | Methods for minimizing bone loss The present invention provides a method for minimizing the bone loss effect of a compound of formula II ##STR1## or a pharmaceutically acceptable salt thereof, wherein said formula II compound is administered to a mammal in need of treatment, compris... | 02/04/1997 |
| 5576337 | Method of treating anxiety by inhibiting physiological conditions associated with an excess of neuropeptide Y A method of inhibiting the physiological disorder anxiety associated with an excess of neuropeptide Y or its symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 | 11/19/1996 |
| 5567820 | Glucopyranoside benzothiophenes A compound of the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation thereof.... | 10/22/1996 |
| 5567715 | Methods of treating depression by inhibiting physiological conditions associated with an excess of neuropeptide Y A method of inhibiting a physiological disorder associated with an excess of neuropeptide Y or its symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R | 10/22/1996 |
| 5567714 | Methods of treating obesity by inhibiting physiological conditions associated with an excess of neuropeptide Y A method of inhibiting obesity, a physiological disorder associated with an excess of neuropeptide Y, or its symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 | 10/22/1996 |
| 5554628 | Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs The present invention provides a method of minimizing the uterotrophic effect of non-steroidal antiestrogen compounds of formula II ##STR1## and wherein the variables are as defined in the specification and wherein said formula II compound is adminis... | 09/10/1996 |
| 5554600 | Methods for inhibiting endometriosis The present invention provides a method for inhibiting endometriosis comprising administering to a woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is hydrogen or methyl; R1 and R2 eac... | 09/10/1996 |
| 5552401 | 2-benzyl-3-arylbenzothiophenes The present invention provides a compound of formula I ##STR1## wherein R1 is hydrogen, a hydroxy protecting group, or methyl; R2 and R3 are independently C1 -C6 alkyl, or R2 and R3 | 09/03/1996 |
| 5550164 | Method for inhibiting uterine fibroid disease with 1,1,2-triphenylbut-1-ene derivatives The present invention provides novel methods of inhibiting uterine fibroid disease and endometriosis in women comprising administering to a woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R1 and R... | 08/27/1996 |
| 5550151 | Methods of reducing scarring in wound healing A method of inhibiting scarring comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, ##STR2## wherein Ar is optional... | 08/27/1996 |
| 5550150 | Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder A method of inhibiting one or more symptom of premenstrual syndrome/late luteal phase dysphoric disorder comprising administering to a female human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R1 | 08/27/1996 |
| 5550134 | Methods for inhibiting bone loss The present invention provides methods of inhibiting bone loss in mammals via the administration to a mammal in need of such treatment an effective amount of a compound from a series of benzoquinolin-3-ones. Such compounds also are sequentially or concurr... | 08/27/1996 |
| 5550123 | Methods for inhibiting bone prosthesis degeneration A method of inhibiting bone prosthesis degeneration comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, ##STR2## ... | 08/27/1996 |
| 5545641 | Methods of inhibiting physiological conditions associated with an excess of bradykinin A method of inhibiting a physiological condition associated with an excess of bradykinin comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are ind... | 08/13/1996 |
| 5545635 | Inhibiting bone loss with equilenin The present invention provides methods of inhibiting bone loss in humans comprising administering to a patient in need of treatment an effective amount of d-equilenin, 17ଲ-dihydroequilenin, and 17-dihydroequilenin, and pharmaceutical formulat... | 08/13/1996 |
| 5530010 | Methods of inhibiting demyelinating and dysmyelinating diseases A method of inhibiting demyelinating or dysmyelinating diseases or their symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independen... | 06/25/1996 |
| 5523309 | Benzofuran pharmaceutical compounds The present invention provides a compound of formula I ##STR1## wherein R1 is H, OH, halo, OCO(C1 -C6 alkyl), OCO(aryl), OSO2 (C4 -C6 alkyl), OCOO(C1 -C6 alkyl), ... | 06/04/1996 |
| 5521214 | Methods of inhibiting environmental estrogens A method of inhibiting effects of environmental estrogens comprising administering to a human or other animal in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydr... | 05/28/1996 |
| 5504094 | Use of bengothiophenls to treat pain due to an excess of neuropeptide y A method of inhibiting a physiological disorder associated with an excess of neuropeptide Y or its symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R | 04/02/1996 |
| 5502074 | Benzothiophenes for bone healing and fracture repair A method of facilitating bone healing and fracture repair comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, ##STR... | 03/26/1996 |
| 5494929 | Methods of inhibiting growth hormone effects A method of inhibiting effects of growth hormone comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, --CH3, ... | 02/27/1996 |
