Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 4867982 | Transdermal drug delivery device A medical device for the transdermal delivery of an active agent through sensitive intact skin is provided. The device comprises a matrix containing the drug having reinforcing means, preferably in the form of a fabric, embedded in the upper surface of th... | 09/19/1989 |
| 4865848 | Skin permeation enhancer compositions using sucrose esters A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predomi... | 09/12/1989 |
| 4865845 | Release rate adjustment of osmotic or diffusional delivery devices A sleeve shaped structure covers a portion of the transport area of a diffusional or osmotic delivery device. The structure is durable and inert to the use environment. Markings on the structure indicate where breaking or cutting will produce a predictabl... | 09/12/1989 |
| 4832953 | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises fo... | 05/23/1989 |
| 4753651 | Self-driven pump A self-driven pump that delivers a flowable composition at a constant baseline rate and may be manipulated to supplement the baseline rate with one or more pulses of the composition. One pump embodiment consists of a rigid hollow housing with one fixed en... | 06/28/1988 |
| 4746515 | Skin permeation enhancer compositions using glycerol monolaurate A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with glycerol monolaurate. Preferred embodiments of therapeutic systems for delivering drug and ... | 05/24/1988 |
| 4723957 | System for delivering drug with enhanced bioacceptability A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.... | 02/09/1988 |
| 4698062 | Medical device for pulsatile transdermal delivery of biologically active agents A medical device and method for the pulsatile administration of a drug through intact skin at a first steady state flux during a first delivery period and a second steady state flux during a second delivery period, said first flux being substantially high... | 10/06/1987 |
| 4681584 | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 μg/cm2 hr and preferably in the range of 50-150 μg/cm2 hr. Ethanol delivere... | 07/21/1987 |
| 4655766 | Fluid imbibing pump with self-regulating skin patch A medical device comprising a fluid imbibing, self-regulating, skin patch drug delivery system is disclosed which includes a fluid imbibing, preferably osmotic, pump comprising a reservoir for a drug or, drug formulation or other fluid to be dispensed to ... | 04/07/1987 |
| 4645502 | Transdermal delivery of highly ionized fat insoluble drugs A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support... | 02/24/1987 |
| 4619652 | Dosage form for use in a body mounted pump A self-contained body mounted pump assembly for continuously administering a therapeutic agent parenterally. The pump has a transparent top through which the contents can be seen and outwardly flaring sides to provide for comfort, stability and other usef... | 10/28/1986 |
| 4615699 | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 μg/cm2 hr and preferably in the range of 50-150 μg/cm2 hr. Ethanol delivere... | 10/07/1986 |
| 4573995 | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine A method for transdermal delivery of naloxone, naltrexone and nalbuphine base through intact skin is described. Preferred embodiments of transdermal therapeutic systems for delivering these drugs and polyethylene glycol monolaurate employ an ethylene viny... | 03/04/1986 |
| 4568343 | Skin permeation enhancer compositions A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with polyethylene glycol monolaurate. Preferred embodiments of transdermal therapeutic systems f... | 02/04/1986 |
| 4564364 | Active agent dispenser The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the... | 01/14/1986 |
| 4559222 | Matrix composition for transdermal therapeutic system Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at l... | 12/17/1985 |
| 4552561 | Body mounted pump housing and pump assembly employing the same A self-contained body mounted pump assembly for continuously administering a therapeutic agent parenterally. The pump has a transparent top through which the contents can be seen and outwardly flaring sides to provide for comfort, stability and other usef... | 11/12/1985 |
| 4539004 | Self-driven pump assembly and method of operation A pump assembly particularly useful as an infusor for parenteral administration of a small amount of a therapeutically active substance for a prolonged period of time at a substantially constant rate comprising a fluid imbibing pump mounted within a recep... | 09/03/1985 |
| 4505702 | Manually operable rotary syringe A manually operated rotary syringe comprises a fixed base member and a relatively rotable cap member, one of which has an arcuate recess and the other of which carries a mating plug which is received in the arcuate recess in fluid tight relationship with ... | 03/19/1985 |
| 4474575 | Self-driven pump assembly and method of operation A pump assembly particularly useful as an infusor for parenteral administration of a small amount of a therapeutically active substance for a prolonged period of time at a substantially constant rate comprising a fluid imbibing pump mounted within a recep... | 10/02/1984 |
| 4460372 | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits... | 07/17/1984 |
| 4436741 | Method for administering scopolamine transdermally Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 μg/cm2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis... | 03/13/1984 |
| 4435180 | Elastomeric active agent delivery system and method of use A transdermal therapeutic system is formed from a body member surrounding means at least a portion of which is an active agent loaded elastomer which is in a stretched condition during use. The tension created by the stretching of the elastomer is prefera... | 03/06/1984 |
| 4419096 | Elastomeric bladder assembly Elastomeric bladder assemblies designed for operation at constant pressure to maintain a constant dispensing rate for the contents exhibit a pressure spike shortly before the end of the duty cycle. This pressure spike may be prevented by including within ... | 12/06/1983 |
| 4386929 | Elastomeric bladder assembly The bladder assembly of this invention has spaced apart inlet and outlet means and the bladder is capable of expanding and contracting radially and axially upon inflation and deflation. When deflated the lumen of the bladder is substantially completely fi... | 06/07/1983 |
| 4379454 | Dosage for coadministering drug and percutaneous absorption enhancer A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits... | 04/12/1983 |
| 4350271 | Water absorbing fluid dispenser A fluid dispenser that operates by absorbing water is disclosed. The dispenser includes a rigid water permeable housing; a water insoluble, water swellable composition that fills a segment of the space within the housing, a lipophilic fluid charge that fi... | 09/21/1982 |
| 4320758 | Osmotically driven fluid dispenser An improved version of an osmotically driven mini-osmotic pump that is used to administer drug solutions. The basic components of the improved pump are: an inner flexible bag that holds the drug solution; a plug having a recessed inner end that seals the ... | 03/23/1982 |
| 4318400 | Medical infusor A portable elastomeric bladder-powered infusor for dispensing drug in liquid form under pressure at a predetermined flow rate is disclosed. The main elements of the infusor are a tubular housing, a plug/flow control assembly fixed in one end of the bladde... | 03/09/1982 |
| 4278087 | Device with integrated operations for controlling release of agent An osmotic device is disclosed for delivering an agent to an environment of use. The device comprises (1) a semipermeable wall, surrounding a compartment with a passageway through the wall for delivering an agent from the compartment, and (2) an osmotic s... | 07/14/1981 |
| 4262003 | Method and therapeutic system for administering scopolamine transdermally Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 μg/cm2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis... | 04/14/1981 |
| 4201207 | Bladder for liquid dispenser An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients, that dispense liquid under pressure from an expansible, elastomer bladder is disclosed. The improvement is that the bladder is made from synthetic vulcanized ... | 05/06/1980 |
| 4201211 | Therapeutic system for administering clonidine transdermally Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrene... | 05/06/1980 |
| 4177256 | Osmotic bursting drug delivery device A drug delivery for administering drug to an aqueous body environment at a substantially constant rate. The devices consist essentially of a mixture of drug of specific average particle size dispersed in a polymer of specific water permeability, tensile s... | 12/04/1979 |
| 4140117 | Cartridge for liquid infusion apparatus A removable cartridge that is used in combination with a liquid drug infusion apparatus that comprises a housing that defines an inlet and outlet and has a recess for receiving the cartridge, a confined flow passageway extending between the inlet and outl... | 02/20/1979 |
| 4127127 | Therapeutic systems made from certain segmented copolyesters Therapeutic systems in the form of drug-containing bags or packets made from films of segmented copolyesters of butylene terephthalate and polyalkylene ether terephthalate are disclosed.... | 11/28/1978 |
| 4111302 | Cartoned medical instrument package A package for an intrauterine device-intrauterine device inserter combination and a "pillow pack" carton for the package are disclosed. The package consists of three elements: (1) a thermoformed plastic tray having an elongated, relatively deep cavity for... | 09/05/1978 |
| 4060084 | Method and therapeutic system for providing chemotherapy transdermally Method and therapeutic system in the form of a bandage for providing chemotherapy transdermally by administering certain drugs to unbroken skin in an initial priming dose that quickly brings the systemic concentration of drug to a therapeutic level, follo... | 11/29/1977 |
| 4052019 | Apparatus and method for winding elastomeric fiber An apparatus and method for winding an elastomeric fiber under no or low tension in which a spool of the fiber is placed between a pair of spaced rotating wheels thus causing the spool to rotate at a predetermined linear velocity, and the fiber is first p... | 10/04/1977 |
