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| Number | Title | Issue Date |
| 6986992 | P450 single nucleotide polymorphism biochip analysis This invention relates to methods and compositions for determining single nucleotide polymorphisms (SNPs) in P450 genes. In preferred embodiments, self extension of interrogation probes is prevented by using novel non self-extension probes and/or methods, thereby im... | 01/17/2006 |
| 6955462 | Mixing chamber An apparatus is provided for mixing and maintaining particulates in liquid suspension, the apparatus comprising a reservoir for holding a fluid containing dispersed particles, a substantially horizontally-disposed mixing plate mounted inside the reservoir, the mixin... | 10/18/2005 |
| 6956077 | Temperature-responsive polymer compound and process for producing the same A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided. ... | 10/18/2005 |
| 6943242 | Design of artificial genes for use as controls in gene expression analysis systems Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from inter- or intragenic regions of a genome. T... | 09/13/2005 |
| 6936166 | Endpiece for a chromatography column A liquid transfer system (100) comprising a net (170) and a net support (160), wherein, the net (170) is integrally joined with the net support (160). The net (170) and the net support (160) are preferably joined by w... | 08/30/2005 |
| 6927045 | Methods and apparatus for template capture and normalization for submicroliter reaction Methods for preparing nanoscale reactions using nucleic acids are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is performed di... | 08/09/2005 |
| 6921638 | Hydrogel-based microarray signal amplification methods and devices therefor Methods and devices for detecting nucleic acid and protein targets on hydrogel microarrays are disclosed. Fluorophores are incorporated into the targets and detected. A linear correlation between target concentration and signal amplitude is maintained through the el... | 07/26/2005 |
| 6919186 | Fluorescent proteins The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The modified G... | 07/19/2005 |
| 6916919 | Isolation of DNA molecules The present invention relates to a process for separating nucleic acid molecules, preferably open circular and supercoiled plasmid DNA and RNA molecules from each other, comprising the steps of providing a solution comprising the molecules; adsorbing the molecules t... | 07/12/2005 |
| 6913935 | Multiple assay method A method for the assay of N samples each containing a compound to be tested, comprises providing N reaction vessels each containing a population of carrier beads and other reagents for performing the assay, where N is at least 2 e.g. 80-4000. Each population of carr... | 07/05/2005 |
| 6905595 | Scalable liquid distribution system for large scale chromatography columns A uniform fluid distribution system (2) for use with a liquid transfer system (100) for maintaining an interface between liquid phases within a large scale separator system including a cell into which liquid may be introduced as discrete phases at an i... | 06/14/2005 |
| D506261 | Chromatography column locking ring | 06/14/2005 |
| 6887990 | Method for deprotecting oligonucleotides A method for purifying an oligonucleotide that comprises providing an oligonucleotide attached to a substrate, wherein the oligonucleotide contains phosphate protecting groups; contacting the oligonucleotide with a reagent, e.g., an organic amine, that cleaves the p... | 05/03/2005 |
| 6875573 | DNA polymerases having amino acid substitutions and homologs thereof Thermostable DNA polymerases both in native form and having single amino acid substitutions and optionally N-terminal deletions are disclosed. These polymerases exhibit a substantial improvement of DNA sequencing performance compared to Taq DNA polymerase. The insta... | 04/05/2005 |
| 6855503 | Heterocyclic FRETdye cassettes for labeling biological molecules and their use in DNA sequencing Exploitation of suitably functionalized heterocyclic molecules, in the design and synthesis of Fluorescence Resonance Energy Transfer (FRET) cassettes and their corresponding dideoxynucleotide terminators culminated into efficient reagents for DNA sequencing. Additi... | 02/15/2005 |
| 6852230 | Method for the manufacture of compositions containing low concentrations of salts Method for desalting an aqueous liquid containing a charged substance comprising the steps of: (i) contacting liquid (I) with an ion-exchanger (1) under conditions permitting binding between ion-exchanger and substance, said ion-exchanger comprising a base matrix ca... | 02/08/2005 |
| 6847035 | Devices and methods for the detection of particles The present invention relates to devices and methods for determining the masses of particles by measuring the time between a first event such as a sample (5) being ionized, (or a beam of electromagnetic radiation being scattered by a particle (15) and ... | 01/25/2005 |
| 6843427 | Method and device for producing a coherent layer of even thickness of liquid or melt on a rotating disk Method and device for continuously producing a coherent layer of a liquid/melt of even thickness by means of centrifugal action along the entire periphery of a rotating disk (13, 113), liquid/melt being supplied to the disk around its entire axis of rotation ... | 01/18/2005 |
| 6841097 | Method of producing porous spherical particles The invention refers to a method of controlling the porosity of porous spherical particles produced from a polysaccharide dissolved in a solvent, in which it can be gelled. The polysaccharide solution is finely divided by mechanical means into spherical droplets whi... | 01/11/2005 |
| D500856 | Chromatography column assembly | 01/11/2005 |
| D500555 | Chromatography column end cap | 01/04/2005 |
| 6835379 | Method of producing IgG A method for producing IgG from plasma for medical applications, comprising at least: (i′) removal of albumin resulting in an IgG fraction, (ii′) purifying IgG from an IgG fraction, which is derived from the IgG fraction obtained in step (i′), by adsorbing IgG... | 12/28/2004 |
| 6833545 | Method and device for performing analyses in parallel The present invention relates to analysis devices having means (3, 5, 7) for producing a plurality of ion beams of samples substantially simultaneously; mass separating means for individually mass separating each ion beam in parallel and detecting means (1... | 12/21/2004 |
| 6828116 | Energy transfer assay method and reagent Disclosed is a non-fluorescent cyanine dye that may be used as an acceptor in fluorescence energy transfer assays involving the detection of binding and/or cleavage events in reactions involving biological molecules, and assay methods utilising such dyes. The non-fl... | 12/07/2004 |
| 6809816 | Measurement of fluorescence decay times Laser pulses from laser head 12 pass through objective lens 16 to a focal spot in sample spot 17. If a pulse hits a fluorophore molecule in the focal spot a fluorescence photon is emitted which is collected by lens 16, reflected by dichro... | 10/26/2004 |
| 6805793 | Separatory material with the use of stimulus-responsive polymer and separation method by using the separatory material A novel method for separating a target substance, for example, metal ion, drug or biological component is provided. According to the method, the surface of a packing undergoes a chemical or physical environmental change under a physical stimulus so that the interact... | 10/19/2004 |
| 6805730 | Convoluted surface hollow fiber membranes Porous hollow polymer fiber membranes having convoluted inside and/or outside surfaces, as well as filter devices comprising a plurality of the hollow fiber membranes, the devices preferably being arranged to direct fluid flow from the inside surface of the membrane... | 10/19/2004 |
| 6800847 | Fast variable gain detector system and method of controlling the same A micro-channel plate (MCP) detector system (30) comprising a MCP detector, a data acquisition unit (20), wherein the detector comprises a first and a second MCP electron multiplier (12, 14), one or more anodes (16) connected to the data ... | 10/05/2004 |
| 6790613 | Method of preparing an oligonucleotide array This invention relates to the improvement of arrays of porous polymer pads on solid supports used in biological assays. The invention involves freeze drying the porous polymer pads to increase pore size. The increased pore size results in an enhanced ability of the ... | 09/14/2004 |
| D495060 | Chromatography column assembly end cap | 08/24/2004 |
| 6766071 | Device and method for the measurement of the heat of a reaction Disclosed is an apparatus for use in the measurement of the heat generated in a chemical or biochemical reaction, by detecting and measuring a change in the conformation of a polymer transducer responsive to a heat change, the transducer being bound to the surface o... | 07/20/2004 |
| 6764215 | Method, a measuring cell and a system for measuring very small heat changes in a sample The present invention relates to a method, a measuring cell and a system for measuring very small heat changes in a sample. The system comprises a measuring cell 16 for containing the sample during the measurement process, at least one electromagnetic radiati... | 07/20/2004 |
| 6748985 | Inlet device and its use An inlet device for a reactor vessel (5) intended for a separation method comprising retaining a substance on a separation medium from a liquid passing through the reactor vessel (5) which contains the separation medium. The device comprises (a) a dist... | 06/15/2004 |
| 6745133 | Mass spectral peak identification The monoisotopic mass peak of an experimentally obtained mass spectrum (262) for a sample molecule is determined using a cross correlation method. A model spectrum (261), having a known monoisotopic peak position, is created based on knowledge of the s... | 06/01/2004 |
| 6720902 | High dynamic range digital converter The present invention provides a single analog-to-digital converter system which is capable of converting an input signal having a high dynamic range into a digital signal which is within the range of the analog-to-digital converter. Additionally, the present invent... | 04/13/2004 |
| 6706486 | Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides The present invention relates to a method for the quantitative release of natural or recombinant proteins, polypeptides (thermostable immunoligands) able to bind to the Fc-part of immunoglobulins (antibodies, in particular of the IgG class and primarily becoming bou... | 03/16/2004 |
| 6706191 | Chromatographic process utilizing a fluidized bed A liquid chromatographic process performed at least partly in a fluidised bed contained in a vessel and comprising particle fluidised by an upwardly directed liquid flow, said process comprising (a) a capture step in which one or more compounds of a sample are captu... | 03/16/2004 |
| 6702943 | Method for anion-exchange adsorption and anion-exchangers A method for the removal of a substance carrying a negative charge and being present in an aqueous liquid (I). The method comprises the steps of: (i) contacting the liquid with a matrix carrying a plurality of ligands comprising a positively charged struc... | 03/09/2004 |
| 6683302 | Method and device for electrospray ionization The present invention relates to electrospray device and a method for heating a liquid in said electrospray device. The device comprising a liquid source (3), a mass analyser (5), and inlet plate (17) with an inlet orifice (19), liquid inlet means such as... | 01/27/2004 |
| 6664058 | Base analogues The present invention describes novel compounds of the formula ##STR1## Wherein Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue, Y=O, S, NR10, where R10 is H, alkyl alkenyl, alkynyl, X is H, alky... | 12/16/2003 |
