Ryan; Richard P. - US Patent Attorneys and Agents

Attorney: Ryan; Richard P.

Number of patents: 108
Last date: July 12, 2005

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Number	Title	Issue Date
6916937	Carbohydrate prodrugs of fluorooxindoles The present invention provides novel prodrug derivatives of fluorooxindoles having the general Formula I wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer, and R1, R	07/12/2005
6821976	S-6-hydroxy-buspirone The S-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The S-isomer may provide reduced potential for adverse effects and a longer duration of action compared to the racemic mixture and with busp...	11/23/2004
6686361	R-6-hydroxy-buspirone The R-stereoisomer of 6-hydroxy-buspirone is an effective treatment for anxiety, depression, and other psychogenic disorders. The R-isomer exhibits greater receptor specificity than the S-isomer and should have reduced potential for the adverse effects as...	02/03/2004
6596724	Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of oxadiazole, thiadiazole and thiadiazole oxide derivatives of dihydropyridines of Formula I. ##STR1## wherein B is ##STR2## with X being O, S or ##STR3## an...	07/22/2003
6593331	Method for treatment of pain A method of treating pain with acetaminophen comprises the concurrent administration of a hydroxyazapirone selected from 6-hydroxybuspirone or 3-hydroxygepirone. This combination of agents results in a more morphine-like analgesic response characterized b...	07/15/2003
6566361	Azapirone pain treatment A method of treating pain with acetaminophen comprises the concurrent administration of an azapirone such as buspirone. This combination of agents surprisingly results in a strengthened analgesic response characterized by rapid onset, greater pain relief,...	05/20/2003
6511982	Treatment of pain A method of treating pain with acetaminophen comprises the concurrent administration of buspirone. This combination of agents surprisingly results in a morphine-like analgesic response characterized by rapid onset, greater pain relief, and a longer durati...	01/28/2003
6479482	Alkylamine derivatives of dihydropyridine NPY antagonists A series of non-peptidergic antagonists of NPY have been synthesized and are comprises of amino and piperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. ##STR1## where X is CH or N As antagonists of NPY-induced behavior, these compounds a...	11/12/2002
6476051	Antipsychotic heterocycle compounds Compounds of Formula I: ##STR1## wherein Ar, Y, m, and Z are as defined in the specification, are useful antipsychotic and antidepressant agents demonstrating potent inhibition of 5-HT reuptake and dopamine D2 receptor antagonism....	11/05/2002
6444675	4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of 4-alkyl and cycloalkyl derivatives of dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced behavior, these compounds are expected to act as eff...	09/03/2002
6432960	Squarate derivatives of dihydropyridine NPY antagonists A series of antagonists of NPY have been synthesized and are comprised of squarate derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant ag...	08/13/2002
6432956	Method for treatment of sleep apneas Certain azapirone compounds and their pharmaceutically acceptable salts are useful in the treatment of sleep apneas....	08/13/2002
6432944	Benzodiazepinone ଲ-amyloid inhibitors: arylacetamidoalanyl derivatives There is provided a series of arylacetamidoalanyl derivatives of benzodiazepinones of Formula I ##STR1## wherein R1 through R7 and n are defined herein, which are inhibitors of ଲ-amyloid peptide (ଲ-AP) production and are ...	08/13/2002
6391881	Thiourea derivatives of dihydropyridine NPY antagonists A series of antagonists of NPY have been synthesized and are comprised of thiourea linked piperazine and piperidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. ##STR1## where Z is NR7 R8 or ##STR2## and X is CH or...	05/21/2002
6312717	Method for treatment of anxiety and depression An improved method of treatment for anxiety and/or depression provides a quicker and more robust anxiolytic/antidepressant activity to a patient suffering from depression. The method comprises the concurrent administration of effective doses of certain az...	11/06/2001
6225324	Antidepressant heterocyclic compounds Compounds of formula I are useful antidepressant agents ##STR1## demonstrating potent inhibition of 5-HT reuptake. Z is selected from among various phenyl and hetaryl moieties while Y is benzyl or indolyl....	05/01/2001
6150365	Anxiety method 6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-piperazinyl]-butyl]-8-azaspiro[4.5]-7,9-d ione and its pharmaceutically acceptable salts and hydrates are useful in the alleviation of anxiety....	11/21/2000
6143325	Nefazodone dosage form Extended-release nefazodone compositions containing nefazodone hydrochloride, ionic and non-ionic gelling polymers, an insoluble hydrophilic agent, and optional pharmaceutically acceptable excipients demonstrate pH-modulated release of nefazodone. These c...	11/07/2000
6096745	Imidazolone anorectic agents: III. heteroaryl derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of heteroaryl derivatives of imidazolone compounds of Formula 1. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs ar...	08/01/2000
6090854	Aryloxyanilides and related compounds There is provided novel aryloxyanilides and related compounds of the formula ##STR1## wherein R1 is --OR, --CO2 R, or halogen with R being C1-4 alkyl; R2 is R, cyclopropyl, C2-4 alkenyl or --CH	07/18/2000
6066336	Cholesterol-lowering tablets An improved cholesterol-lowering tablet is manufactured by blending tablet grade cholestyramine with an appropriate amount of lubricant and directly compressing into elongated tablets having a specified thickness. These inner tablets are successfully film...	05/23/2000
6063934	Imidazolone anorectic agents: 1. 2-substituted-3,5-dihydro-5,5-diphenyl-4H-imidazol-4-ones A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of acyclic derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are e...	05/16/2000
6054590	Imidazolone anorectic agents: II. phenyl derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expecte...	04/25/2000
6034085	Salt form of nefazodone for use in extended release formulations The crystalline, stable methanesulfonate salt of nefazodone showed significantly higher intrinsic dissolution in water and THAM buffer (pH 7.5) compared to other salts of nefazodone. The faster dissolution rate of this salt at neutral pH suggests better d...	03/07/2000
6008222	Method for oral administration of buspirone and nefazodone An improved method for orally administering buspirone to a human subject wherein the bioavailability of buspirone is increased and its elimination, metabolite formation, and variability of these pharmacokinetic parameters is decreased, the improvement com...	12/28/1999
6001836	Dihydropyridine NPY antagonists: cyanoguanidine derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are ex...	12/14/1999
5880106	Oral dosing formulations of dideoxy purine nucleosides Improved oral dosage formulations for acid-labile dideoxy purine nucleoside derivatives such as ddA, ddI, and ddG, have been developed by incorporating selected water-insoluble buffering systems in the formulation. These novel formulations provide reduced...	03/09/1999
5859033	Anticonvulsant pyridinyl benzamide derivatives A series of pyridinyl tri-substituted benzamide derivatives of general structure ##STR1## wherein the symbols R1, R2, X and n are described in detail in the specification, are useful as anticonvulsants agents....	01/12/1999
5854248	Nefazodone: use in migraine prophylaxis Nefazodone and its pharmaceutically acceptable salts are useful in prophylactic treatment of recurrent headache disorders, as, in particular, vascular and migraine headaches....	12/29/1998
5852020	Nefazodone: use in treating post traumatic stress disorder Nefazodone and its pharmaceutically acceptable salts are useful in alleviation of post traumatic stress disorder....	12/22/1998
5703129	5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of ଲ-amyloid protein production A series of 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives of Formula I have been synthesized. ##STR1## As inhibitors of the production of ଲ-amyloid protein from ଲ-amyloid precursor protein, these compounds are expected to be ...	12/30/1997
5703239	Indanylpiperidines as melatonergic agents Certain indanyl piperidines are useful as melatonergic agents and can treat various CNS disorders. They are useful in treating sleep disorders and other conditions related to circadian rhythms....	12/30/1997
5672698	Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-,acyl-2'଱-halo-3'଱-alkanesulfonylthymidine intermediat...	09/30/1997
5668151	Dihydropyridine NPY antagonists: piperidine derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these comp...	09/16/1997
5635503	Dihydropyridine npy antagonists: piperazine derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compou...	06/03/1997
5618816	Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines A series of novel 5-(3,4-diamino-1,2,5-thiadiazole and S-oxide) derivatives of indolylalkylpiperazinyl pyridines and pyrimidines of Formula I are intended for use in the alleviation of vascular headaches. ##STR1## In Formula I, X is selected from S, ...	04/08/1997
5607961	Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives Certain 3-amino-cycloalkanyl and cycloalkenyl derivatives of 5-cyano-substituted indoles of Formula I are useful antidepressant agents. ##STR1## The substituent R1 is hydrogen or C1-4 alkyl and R2 is C1-4 a...	03/04/1997
5608049	Preparation of d4T from 5-methyluridine The present invention concerns an improved process of making d4T from 5-MU. Another aspect of the invention relates to useful intermediates produced during the process....	03/04/1997
5583149	Antimigraine derivatives of indolylcycloalkanylamines A series of novel serotonergic indolyl derivatives of cycloalkanyl- and cycloalkenyl-amines of Formula I are intended for use in the alleviation of vascular headaches. ##STR1##...	12/10/1996
5554621	Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are ...	09/10/1996

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Attorney: Ryan; Richard P.