Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8153664 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond,... | 04/10/2012 |
| 8138180 | Exo-selective synthesis of himbacine analogs This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbam... | 03/20/2012 |
| 8022088 | Substituted bicyclic and tricyclic thrombin receptor antagonists Substituted bicyclic and tricyclic modified himbacine derivative of the formula: or a pharmaceutically acceptable salt or solvate of said compound wherein represents an optional double bond and wherein En, F... | 09/20/2011 |
| 8003803 | Fused ring thrombin receptor antagonists Fused-ring, heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an option... | 08/23/2011 |
| 7989653 | Exo- and diastereo-selective syntheses of himbacine analogs This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be... | 08/02/2011 |
| 7888377 | Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonists Monocyclic and bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt or solvate of said compound wherein represents an optional double bond and wherein G | 02/15/2011 |
| 7888369 | Oxazoloisoquinoline derivatives as thrombin receptor antagonists This application provides for oxazolisoquinoline derivatives of the formula or a pharmaceutically acceptable salt of said compound wherein: B is —CH═CH—; ... | 02/15/2011 |
| 7803828 | Functionally selective alpha2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma... | 09/28/2010 |
| 7776889 | Spirocyclic thrombin receptor antagonists Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond,... | 08/17/2010 |
| 7772276 | Exo-selective synthesis of himbacine analogs This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbam... | 08/10/2010 |
| 7741289 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 06/22/2010 |
| 7732413 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 06/08/2010 |
| 7700592 | α2C adrenoreceptor agonists In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, in... | 04/20/2010 |
| 7635705 | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine Hantagonists Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF o... | 12/22/2009 |
| 7612058 | Methods for inhibiting sterol absorption The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor whic... | 11/03/2009 |
| 7560449 | Methods and therapeutic combinations for the treatment of demyelination The present invention provides methods for treating demyelination and associated conditions by administering at least one sterol absorption inhibitor and compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor; and ... | 07/14/2009 |
| 7531544 | Xanthine phosphodiesterase V inhibitors A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: For ... | 05/12/2009 |
| 7482468 | Imidazole and benzimidazole derivatives useful as histamine Hantagonists Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: n is 2-5; R is R3-aryl, R3-heteroaryl, R | 01/27/2009 |
| 7459442 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 12/02/2008 |
| 7417039 | Use of substituted azetidinone compounds for the treatment of sitosterolemia The present invention is directed to the use of sterol absorption inhibiting compounds, pharmaceutical compositions thereof, therapeutic combinations and their use in combination with other lipid lowering agents to treat or prevent sitosterolemia and/or to lower the... | 08/26/2008 |
| 7408066 | Carbon-linked substituted piperidines and derivatives thereof useful as histamine Hantagonists Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; | 08/05/2008 |
| 7378518 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 05/27/2008 |
| 7368563 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 05/06/2008 |
| 7368562 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 05/06/2008 |
| 7268141 | Xanthine phosphodiesterase V inhibitors A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: | 09/11/2007 |
| 7235543 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituen... | 06/26/2007 |
| 7208486 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituen... | 04/24/2007 |
| 7192944 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituen... | 03/20/2007 |
| 7132415 | Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors The present invention provides therapeutic combinations and methods including at least one sterol or 5α-stanol absorption inhibitor that can be useful for treating xanthomas. ... | 11/07/2006 |
| 7105505 | Benzimidazole derivatives useful as histamine H3 antagonists Disclosed are novel compounds of the formula wherein R1 is optionally substituted benzimidazolyl or a derivative thereof; R2 is optionally substituted aryl or heteroaryl; M1 and M... | 09/12/2006 |
| 7053080 | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors The present invention provides methods for the treatment of obesity using sterol or 5α-stanol absorption inhibitors and compositions and therapeutic combinations including sterol or 5α-stanol absorption inhibitors and at least one obesity control medication. ... | 05/30/2006 |
| 6852705 | DNA vaccines for farm animals, in particular bovines and porcines Improved vaccines or immunogenic or immunological compositions, and methods for making and using the same. ... | 02/08/2005 |
| 6805233 | Conveyor slat of a fiber reinforced thermoplastic material The invention relates to a reciprocating slat conveyor comprising a plurality of side by side disposed elongated conveyor slats, means for attaching the slats to at least one of a plurality of longitudinally spaced apart transversely extending drive beams for drivin... | 10/19/2004 |
| 6797724 | Direct spot-on antiparasitic skin solution for domestic animals A spot-on composition for the treatment or protection of a domestic animal against parasitic infestation comprising, (a) an insecticidal active substance of the formula (X): (b) an organic solvent; and (c) ... | 09/28/2004 |
| 6281430 | Electronic device comprising a columnar discotic phase An electronic device comprising two adjacent regions of materials with different electric properties is characterized in that one of the regions is formed by a columnar structure of a discotic liquid crystal material, said structure having interspaces def... | 08/28/2001 |
