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| Number | Title | Issue Date |
| 5718919 | Nanoparticles containing the R(-)enantiomer of ibuprofen There is described a composition comprised of nanoparticles of a therapeutic agent having a surface modifier adsorbed on the surface thereof. The present composition is characterized in that the therapeutic agent is ibuprofen or fenoprofen which is substa... | 02/17/1998 |
| 5716642 | Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the p... | 02/10/1998 |
| 5668196 | 3-amido-triiodophenyl esters as x-ray contrast agents This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 0 t... | 09/16/1997 |
| 5662883 | Microprecipitation of micro-nanoparticulate pharmaceutical agents It has been known that administration of pharmaceutical agents (both diagnostic and therapeutic) with poor water solubility in the form of particles less than 400 nm in diameter produces agent formulation with increased bioavailibility. Bioavailability be... | 09/02/1997 |
| 5643552 | Nanoparticulate diagnostic mixed carbonic anhydrides as x-ray contrast agents for blood pool and lymphatic system imaging This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen, and/or lymph system of a mammal comprising administering a contrast effective amount of a mixed carbonic anhydride as a contrast agent having the structure #... | 07/01/1997 |
| 5628981 | Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents Nanoparticulate crystalline x-ray contrast agents are formulated with stabilizers to enhance contact between the crystalline x-ray contrast agents and the gastrointestinal tract. Nanoparticulate crystalline therapeutic substances also formulated with stab... | 05/13/1997 |
| 5622938 | Sugar base surfactant for nanocrystals Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier having the formula: ##STR1## wherein R is phenyl-(CH2)10 CO or C12 H25 NHCO adsorbed on the surface the... | 04/22/1997 |
| 5603916 | 3 5-bis alkanoyl amino-2 4 6-triiodobenzyl esters This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 2; ... | 02/18/1997 |
| 5593657 | Barium salt formulations stabilized by non-ionic and anionic stabilizers Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising nanoparticles of a barium salt having associated with its surface non-ionic and anionic stabilizers; and methods for their use in diagnos... | 01/14/1997 |
| 5591456 | Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer Dispersible particles consisting essentially of crystalline NSAID having hydroxypropyl cellulose adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm. Pharmaceutical compositions... | 01/07/1997 |
| 5587143 | Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene ... | 12/24/1996 |
| 5580579 | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers Nanoparticulate crystalline therapeutic or diagnostic substances formulated with stabilizers and high molecular weight, linear poly(ethylene oxide) polymers, enhance contact between the crystalline therapeutic or diagnostic substances and the gastrointest... | 12/03/1996 |
| 5573783 | Redispersible nanoparticulate film matrices with protective overcoats A pharmaceutical film matrix comprising nanoparticles of a low solubility drug associated with a steric stabilizer and a film dispersing agent is coated on the surface of carrier particles and overcoated with a protective layer. Pharmaceutical composition... | 11/12/1996 |
| 5573749 | Nanoparticulate diagnostic mixed carboxylic anhydrides as X-ray contrast agents for blood pool and lymphatic system imaging This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen, and/or lymph system of a mammal comprising administering a contrast effective amount of a mixed carbonic anhydride as a contrast agent having the structure #... | 11/12/1996 |
| 5571536 | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids Nanoparticulate crystalline drug substances formulated in an aqueos phase emulsified in oil, are able to be made at less than 1000 nm size and provide increased bioavailability and lymphatic uptake following oral administration.... | 11/05/1996 |
| 5569448 | Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a block copolymer linked to at least one anionic group as a surface modifier adsorbed on the surface thereof and a method of making such n... | 10/29/1996 |
| 5565188 | Polyalkylene block copolymers as surface modifiers for nanoparticles There is disclosed a composition containing nanoparticles having a surface modifier wherein the surface modifier is a block copolymer containing one or more polyoxyethylene blocks and one or more polyoxy(higher alkylene) blocks wherein at least some of th... | 10/15/1996 |
| 5560932 | Microprecipitation of nanoparticulate pharmaceutical agents This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the p... | 10/01/1996 |
| 5560931 | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids Nanoparticulate crystalline drug substances formulated in an aqueos phase emulsified in oil, are able to be made at less than 1000 nm size and provide increased bioavailability and lymphatic uptake following oral administration.... | 10/01/1996 |
| 5552160 | Surface modified NSAID nanoparticles Dispersible particles consisting essentially of a crystalline NSAID having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm. Pharmaceutical compositions con... | 09/03/1996 |
| 5543133 | Process of preparing x-ray contrast compositions containing nanoparticles A process of preparing nanoparticulate contrast agents comprising the steps of: preparing a premix of the contrast agent and a surface modifier; and subjecting the premix to mechanical means to reduce the particle size of the contrast agent, the mechanical mea... | 08/06/1996 |
| 5534270 | Method of preparing stable drug nanoparticles Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by ... | 07/09/1996 |
| 5525328 | Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging This invention relates to methods of x-ray diagnostic imaging the blood pool and/or lymph system of a mammal comprising administering a contrast effective amount of a particulate iodinated aroyloxy ester contrast agent having the structure: ##STR1## ... | 06/11/1996 |
| 5521218 | Nanoparticulate iodipamide derivatives for use as x-ray contrast agents This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: R is alk... | 05/28/1996 |
| 5518738 | Nanoparticulate nsaid compositions A composition comprising a crystalline NSAID having polyvinylpyrrolidone adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm, hygroscopic sugar and sodium lauryl sulfate exhibit... | 05/21/1996 |
| 5518187 | Method of grinding pharmaceutical substances A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced c... | 05/21/1996 |
| 5510118 | Process for preparing therapeutic compositions containing nanoparticles A process of preparing nanoparticulate drug substances comprising the steps of: preparing a premix of the drug substance and a surface modifier, and subjecting the premix to mechanical means to reduce the particle size of the drug substance, the mechanica... | 04/23/1996 |
