Roth; Carol J. - US Patent Attorneys and Agents

Attorney: Roth; Carol J.

Number of patents: 72
Last date: May 03, 2005

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Number	Title	Issue Date
6887865	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	05/03/2005
6864368	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	03/08/2005
6864263	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	03/08/2005
6849739	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	02/01/2005
6846829	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	01/25/2005
6841674	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	01/11/2005
6841673	N-heterocyclic derivatives as nos inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	01/11/2005
6747031	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these...	06/08/2004
6740636	Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection This invention is directed to pharmaceutical compositions useful in treating heart transplant rejection in mammals comprising a pharmaceutically acceptable excipient, a therapeutically effective amount of a non-peptide CCR1 receptor antagonist and a sub-nephrotoxic ...	05/25/2004
6686364	Benzamidine derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states...	02/03/2004
6573266	Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives of the following formula (Id): ##STR1## wherein R1b, R3, R4, R5, R6 and R10 are described herein. These derivatives are useful as a...	06/03/2003
6559147	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5, R6	05/06/2003
6555537	Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): ##STR1## wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives a...	04/29/2003
6552030	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5, R6	04/22/2003
6541476	Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): ##STR1## wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives a...	04/01/2003
6534509	Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives, for example, of the following formula (1a): ##STR1## wherein R1a, R2, R3, R4, R5, and R6 are descried herein. These derivatives ar...	03/18/2003
6525051	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives selected from the group consisting of the following formulae: ##STR1## where Z1, Z2, Z3, R1, R2, R3, R4, R5 and R6 are described ...	02/25/2003
6498185	Ortho-anthranilamide derivatives as anti-coagulants This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R1, R2 and R3 are disclosed herein. These compounds are disclosed as being useful as anti coagulants....	12/24/2002
6495574	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5, R6	12/17/2002
6495684	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formula: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5, R6	12/17/2002
6492376	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5, R6	12/10/2002
6479485	Benzamidine derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states...	11/12/2002
6465459	Benzamidine derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states...	10/15/2002
6432947	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): ##STR1## are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors o...	08/13/2002
6380221	Ortho-anthranilamide derivatives as anti-coagulants This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R1, R2 and R3 are disclosed herein. These components are disclosed as being useful as anti-coagulants....	04/30/2002
6372751	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5 and R	04/16/2002
6350761	Benzenamine derivatives as anti-coagulants This invention is directed to benzenamine derivatives of formula (I): ##STR1## wherein A, W, m, n, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants....	02/26/2002
6350746	Benzamidine derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states...	02/26/2002
6306884	Benzamidine derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states...	10/23/2001
6265404	Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the ...	07/24/2001
6262088	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5, R6	07/17/2001
6242454	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and...	06/05/2001
6232325	Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatves and their use as anti-coagulants This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the ...	05/15/2001
6221886	Thio acid derived monocyclic N-heterocyclics as anticoagulants This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invent...	04/24/2001
6207665	Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives of formula (Ia): ##STR1## wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This ...	03/27/2001
6177473	Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the ...	01/23/2001
6166014	Thio acid derived monocyclic N-heterocyclics as anticoagulants This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invent...	12/26/2000
6166088	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and...	12/26/2000
6162807	Thio acid derived monocyclic N-heterocyclics as anticoagulants This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invent...	12/19/2000
6150382	Thio acid derived monocyclic n-heterocyclics as anticoagulants This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invent...	11/21/2000

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Attorney: Roth; Carol J.