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| Number | Title | Issue Date |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 6401724 | Method of applying a cosmetic nail lacquer or polish to a nail A method of applying a cosmetic nail lacquer or polish to a nail of an animal is disclosed. The method comprises applying a polyurea composition to the nail. Such nail composition is selected from a reaction solution, a stabilized reaction solution, a blo... | 06/11/2002 |
| 5766874 | Kit containing d-arabinitol dehydrogenase and NAD+ for determining d-arabinitol A D-arabinitol dehydrogenase enzyme is prepared that is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. T... | 06/16/1998 |
| 5330986 | Indole-7-carboxamide derivatives This invention relates to indole-7-carboxamide derivatives of the formula ##STR1## where R1 through R6 are independently H, loweralkyl, aryl, and aralkyl; and in addition R3 and R5 can be joined together to ... | 07/19/1994 |
| 5215984 | Antihypertensive spiro(piperidine- pyrrolidine- or hexahydroazepinyl substituted) pyrrolo(2,1-c)(1,4)benzoxazepines) This invention relates to spiro-](piperidine-, pyrrolidine-, or -hexahydroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lo... | 06/01/1993 |
| 5017578 | N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents This invention relates to a N-heteroaryl-purin-6-amine of the formula ##STR1## where R1 is hydrogen, lower alkyl, and arylloweralkyl; R2 and R3 are independently hydrogen, lower alkyl or R2 and R3 ... | 05/21/1991 |
| 4988690 | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF3, NO2, CN an... | 01/29/1991 |
| 4971992 | Carbonate derivatives of eseroline This invention relates to 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol carbonate esters of the ##STR1## the pharmaceutically acceptable acid addition salts thereof and where applicable to the geometric and optical isomers and... | 11/20/1990 |
| 4960767 | Isoxazolobenzoxazepines This invention relates to isoxazolobenzoxazepines having the following formula ##STR1## wherein X1 is H; X2 is H or OH; or X1 and X2 taken together are carbonyl oxygen or ##STR2## R is (1) H, (2) ... | 10/02/1990 |
| 4908360 | 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetr ahydro-2H-1,3-benzodiazepine-2-ones This invention relates to 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodiazep ine-2-ones having the formula ##STR1## where R1 and R2 are each independently hydrogen, loweralkyl, aryl, arylloweralkyl, a... | 03/13/1990 |
| 4873234 | Isoxazolobenzoxazepines This invention relates to isoxazolobenzoxazepines having the following formula ##STR1## wherein X1 is H; X2 is H or OH; or X1 and X2 taken together are carbonyl oxygen or ##STR2## R is (1) H, (2) ... | 10/10/1989 |
| 4812450 | Spiro((piperidine-pyrrolidine- or hexahydroazepinyl substituted) pyrrolo(2,1-C) (1,4)benzoxazepines) This invention relates to spiro-[(piperidine-, pyrrolidine-, or -hexahyroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, low... | 03/14/1989 |
| 4751238 | Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins This invention relates to substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins of the formula: ##STR1## where X is hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF3 ; R is H, and lower alkyl, R | 06/14/1988 |
| 4670447 | Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles Novel 3-(piperidinyl- and 3-(pyrrolidinyl)-1H-indazoles, intermediates and processes for the preparation thereof, and methods for treating psychoses, treating depression, alleviating pain, treating convulsions and treating hypertension utilizing compounds... | 06/02/1987 |
| 4668690 | 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans useful as analgesics, anticonvulsants or antidepressants This invention relates to 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans of the formula ##STR1## where X is hydrogen, loweralkyl, F and Cl; R1 is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl, loweralkoxyloweralkyl, aryloxylo... | 05/26/1987 |
| 4645737 | Enzyme/immunofluorescent assay for anti-treponemal antibodies A method for the determination of anti-treponemal antibody in a test sample comprises contacting a substrate for the anti-treponemal antibody with sample; treating the contacted substrate with labeled antihuman Ig antibody selected from (a) a mixture comp... | 02/24/1987 |
| 4594435 | Intermediates for 2'-substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] 2'-substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and methods of preparing same are described. On the aromatic portion of the benzofuran ring, there may be a substituent or substituents including halogen, amino, lower-alkyl-substituted amino, lower a... | 06/10/1986 |
| 4585779 | cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and intermediates thereof cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and methods of preparing same are described. On the nitrogen atom there may be a substituent including loweralkyl, loweralkenyl, phenylloweralkyl, hydrogen cyanoloweralkyl, phenylcarbonyllowera... | 04/29/1986 |
| 4578394 | Cholinergic function increasing 3-[N-(pyridyl) carbamoyl]-1,4-dihydropyridines This invention relates to 1,4 dihydropyridines having the following formula ##STR1## wherein R is loweralkyl or Arloweralkyl; R1, R2 and R3 may be the same or different and are hydrogen, loweralkyl or halogen; X is hy... | 03/25/1986 |
| 4576960 | 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives This invention relates to 6,11-dihydro-11-oxo-dibenz[b, e]oxepin derivatives of the formula ##STR1## where Y is hydrogen, alkyl, alkoxy, halogen and trifluoromethyl, n is 0, 1, 2 or 3; R9 is hydrogen and alkyl; R is ##STR2## wher... | 03/18/1986 |
| 4551474 | Methods of alleviating convulsions and pain employing 4-aryloxy-1,2,3,4 tetrahydroisoquinolines This invention relates to 4-aryloxy-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl alkoxy and nitro; R is hydrogen and alkyl; R1... | 11/05/1985 |
| 4544745 | Cis-4a-aryl, 1, 2, 3, 4, 4A, 9B-hexahydro-benzofuro-[3,2-C]- pyridines useful as analgesics Cis-4a-aryl, 1, 2, 3, 4, 4A, 9B-hexahydro-benzofuro-[3,2-C]- pyridines, useful as analgesic and anticonvulsant agents are described.... | 10/01/1985 |
| 4532333 | 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines The invention relates to 1-(aminoalkylphenyl and aminoalkylbenzyl)indoles and indolines of the formula: ##STR1## where R1 and R2 are the same or different and are hydrogen, lower alkyl, cycloalkyl and acyl of the formula ##... | 07/30/1985 |
| 4526891 | Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins This invention relates to compounds of the formula: ##STR1## where X is hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF3 ; R is H, and lower alkyl, R1 is CH3 SO3 and ##STR2## where... | 07/02/1985 |
| 4517311 | 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and methods of praparing same are described. On the aromatic portion of the benzofuran ring, there may be a substituent or substituents including halogen, amino, lower-alkyl-substituted amino, lower a... | 05/14/1985 |
| 4515946 | 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives This invention relates to 6,11-dihydro-11-oxo-dibenz[b,e]oxepin derivatives of the formula ##STR1## where Y is alkyl, alkoxy, halogen or trifluoromethyl, n is 0, 1, 2 or 3; R is ##STR2## where Hal is a halogen; ##STR3## where n is... | 05/07/1985 |
| 4514411 | Substituted 4,10-dihydro-10-oxothieno benzoxepins This invention relates to substituted 4,10-dihydro-10-oxothieno benzoxepins of the formula, ##STR1## where R is hydrogen and lower alkyl; R1 is ##STR2## where R2 is hydrogen, lower alkyl and benzyl of the formula ##STR... | 04/30/1985 |
| 4487934 | Method of preparing poly-substituted acylbenzenes A method of preparing substituted acylbenzenes is disclosed. The method comprises reacting selected acylhalides or equivalents with a selected poly-substituted benzene in the presence of an acylating catalyst comprising a perfluoro sulfonic acid polymer.... | 12/11/1984 |
| 4477670 | 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines This invention relates to 4-aryloxy-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl alkoxy and nitro; R is hydrogen and alkyl; R1... | 10/16/1984 |
| 4477465 | Substituted 4,10-dihydro-10-oxothieno benzoxepins This invention relates to substituted 4,10-dihydro-10-oxothieno benzoxepins of the formula, ##STR1## where R is hydrogen and lower alkyl; R1 is ##STR2## where R2 is hydrogen, lower alkyl and benzyl of the formula ##STR... | 10/16/1984 |
| 4464165 | Material and method for removing immunoglobulins from whole blood An immunoadsorbent material comprising inactivated, protein-A bearing Staphlococcus aureus immobilized in a polymeric matrix is used to remove IgG immunoglobulins and immune complexes from whole blood.... | 08/07/1984 |
| 4461728 | Preparation of 4-phenyl-1,3-benzodiazepins The invention relates to compounds of the formula ##STR1## where Y is --OH; halogen; ##STR2## where R1 is a straight chain or branched chain alkyl group having 1 to 5 carbon atoms, or aryl; and R2 is --C(CH3) | 07/24/1984 |
| 4452803 | Pyrrolylaminopiperidines This invention relates to pyrrolylaminopiperidines and related compounds of the formula ##STR1## where R is hydrogen, loweralkyl, Arloweralkyl, cycloalkylloweralkyl, loweralkenyl and thienylloweralkyl; R1 is lower alkyl, hydrogen, low... | 06/05/1984 |
| 4448784 | 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof The invention relates to 1-(aminoalkylphenyl and aminoalkylbenzyl)indoles and indolines of the formula: ##STR1## where R1 and R2 are the same or different and are hydrogen, lower alkyl, cycloalkyl and acyl of the formula ##... | 05/15/1984 |
| 4430335 | Substituted 1-azaspiro[4,5]decanes and their analgesic compositions This invention relates to substituted 1-azaspiro[4.5] decanes and 1-azaspiro[5.5]undecanes of the formula ##STR1## wherein R1 is hydrogen, --CO2 R4, R4 ; R2 is hydrogen, ##STR2## R... | 02/07/1984 |
| 4420485 | 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] This invention relates to 1'-[3-(1,2-benzisoxazol-3-yl)propyl]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] of the formula: ##STR1## where X and Y are the same or different and are hydrogen, halogen, lower alkoxy, lower alkyl, ... | 12/13/1983 |
| 4404221 | 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and methods of preparing same are described. On the aromatic portion of the benzofuran ring, there may be a substituent or substituents including halogen, amino, lower-alkyl-substituted amino, lower a... | 09/13/1983 |
| 4375471 | 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines This invention relates to 4-aryloxy-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## , where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl alkoxy and nitro; R is hydrogen and alkyl; R | 03/01/1983 |
| 4337261 | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics Novel (1,2-benzisoxazol)phenoxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretics.... | 06/29/1982 |
| 4335122 | Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula ##STR1## wherein R is ##STR2## where R4 is a hydrogen or an alkyl; R1 is hydrogen or alkyl; R2 and R | 06/15/1982 |
