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| Number | Title | Issue Date |
| 8153009 | Apparatus and methods for mass-spectrometric directed purification of biopolymers A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (110), and flowing a solvent having a time-varying composition through the conduit (110). An apparat... | 04/10/2012 |
| 8119981 | Mass spectrometer A fault detection system for protecting a mass spectrometer from the effects of temperature extremes. The system comprises an ion block, a thermal source for providing thermal energy to the ion source block, a temperature sensor providing a reading for the temperatu... | 02/21/2012 |
| 8084888 | Method for the production of high amplitude RF voltages with control of the phase angle between outputs A method of producing high frequency high amplitude AC voltages with control of the phase angle between outputs from a plurality of generators having individual DC current controlled variable inductors which method comprises controlling the timing of the circuit to ... | 12/27/2011 |
| 8076635 | Apparatus and method for performing mass spectroscopy Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair i... | 12/13/2011 |
| 7960694 | Mass spectrometer A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass ((analyser 2). The amplitude or depth o... | 06/14/2011 |
| 7951597 | Pressurized fluid sample injector and method of injecting fluid samples The present invention is a pressurized fluid sample injector system consisting of a sample needle, multiport valve, sample loop, metering syringe and a pressure assist pump. The speed of sample transport into the sample loop is increased by pressurizing the fluid in... | 05/31/2011 |
| 7943900 | Mass analysis using alternating fragmentation modes A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components ... | 05/17/2011 |
| 7928363 | Mass spectrometer A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source (1) are transmitted to a fragmentation device (4) ... | 04/19/2011 |
| 7919747 | Mass spectrometer An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). ... | 04/05/2011 |
| 7897917 | Methods and apparatus for performing chromatography and mass spectroscopy with supercritical fluid samples Embodiments of the present invention are directed to devices and methods for receiving NSC Fluids having at least one analyte from a chromatograph and directing analyte ions into the vacuum regions of a mass spectrometer. The device has a housing having at least one... | 03/01/2011 |
| 7872224 | Apparatus and method for positioning a discharge tube with respect to an orifice Embodiments of the present invention facilitate servicing or changing a discharge tube or modifying the position of a discharge tube with respect to a orifice of a detector and/or a nebulizing gas conduit. The apparatus features a discharge tube housing that slidabl... | 01/18/2011 |
| 7863561 | Mass-spectrometer interface housing An apparatus for performing chemical analyses includes a mass spectrometry module and an interface module that processes sample materials for delivery to the mass spectrometry module. The interface module includes a vessel having an opening to access a vessel chambe... | 01/04/2011 |
| 7863557 | Mass spectrometer A multi-turn Time of Plight mass analyzer is disclosed comprising a first electric sector (5) and a second electric sector (8). The second electric sector (8) is arranged orthogonal to the first electric sector (5). Ions may make multiple... | 01/04/2011 |
| 7858932 | Capillary emitter for electrospray mass spectrometry Disclosed herein is an electrospray device for mass spectrometry that includes a fluid inlet, an outlet orifice, and a passage for fluid communication between the fluid inlet and outlet orifice. This passage is formed from a capillary (i.e., a first capillary). This... | 12/28/2010 |
| 7851751 | Mass analysis with alternating bypass of a fragmentation device A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to f... | 12/14/2010 |
| 7851744 | Mass spectrometer A Matrix Assisted Laser Desorption Ionization ion source or ion imaging device is disclosed comprising a laser (1) and a zoom lens (3, 4, 5). The zoom lens (3, 4, 5) is arranged to be able to vary the magnification of a laser beam which is direc... | 12/14/2010 |
| 7851742 | Method and apparatus for identifying proteins in mixtures A system and method for mass analysis where a sample (102) is separated in a liquid chromatograph (104), and subsequently analyzed in a mass spectrometer (112). ... | 12/14/2010 |
| 7841190 | Freeze-thaw valve that self-limits cryogenic agent usage Methods and devices for the management of cryogenic agents within analytical systems using freeze thaw valving having an expansion chamber that limits the flow of the cryogenic agent. The expansion chamber is fitted with an expansion nozzle through which a cryogen f... | 11/30/2010 |
| 7829849 | Mass spectrometer A device (6) for separating ions according to differences in their ion mobility as a function of electric field strength is disclosed. The device (6) comprises an upper electrode (7a), a lower electrode (7b) and a plurality ... | 11/09/2010 |
| 7829841 | Mass spectrometer A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (4) and an ion guide (6) arranged downstream of the ion mobility spectrometer or separator (4). A plurality of axial potential wells are created in the ion gui... | 11/09/2010 |
| 7820966 | Mass spectrometer A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system (10) which is interfaced to a combustion chamber (16) and isotope ratio mass analyser (19) by means of an Electrospray Ionisation ion source (11) and... | 10/26/2010 |
| 7800055 | System and method for grouping precursor and fragment ions using selected ion chromatograms LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After ... | 09/21/2010 |
| 7683314 | Mass spectrometer A mass spectrometer is disclosed comprising an ion beam attenuator which attenuates an ion beam repeatedly switching between a zero transmission mode of operation during a time period ΔT1 and a non-zero transmission mode of operation during a time period ΔT2 | 03/23/2010 |
| 7674375 | Closed loop flow control of a HPLC constant flow pump to enable low-flow operation A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent compositions gradients typically used in HPLC... | 03/09/2010 |
| 7635841 | Method of mass spectrometry A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P×T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is ... | 12/22/2009 |
| 7622711 | Mass spectrometer A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (... | 11/24/2009 |
| 7596988 | High performance liquid chromatography sample introduction optimized with bubble detection A device (100) for detecting a condition in a fluid system (14) and initiating a response based on the condition. The device consists of a sensor (12) that responds to a first and second condition of the fluid (13) in the system and a con... | 10/06/2009 |
| 7427752 | Mass spectrometer A magnetic sector mass spectrometer is disclosed comprising an ion detector (11) wherein a reflecting electrode (13) is used to divide an ion beam in the direction of mass dispersion into two separate ion beams. The two ion beams are directed onto two ... | 09/23/2008 |
| 7418352 | Method of using data binning in the analysis of chromatography/spectrometry data Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sa... | 08/26/2008 |
| 7417226 | Mass spectrometer An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1, a reaction chamber 2 and a passage 6 connecting the corona discharge chamber 1 to the rea... | 08/26/2008 |
| 7405401 | Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry There is disclosed a method of selectively extracting ions comprising the steps of: providing a supply of ions in a body of gas; generating a ponderomotive ion trapping potential generally along an axis; generating further potentials to provide ... | 07/29/2008 |
| 7396469 | Backflow prevention for high pressure gradient systems Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention ad... | 07/08/2008 |
| 7374054 | Sample vial and vial closure device for use in gas analysis A vial closure device, a sample vial incorporating such a vial closure device, and certain methods of using such a vial and closure device. The vial and closure device are intended to contain a gaseous sample or a headspace gas present above a liquid or solid materi... | 05/20/2008 |
| 7365309 | Mass spectrometer A mass spectrometer and a method of mass spectrometry are disclosed wherein periodic background noise is effectively filtered out from the mass spectral data. An overall mass window is superimposed upon the mass spectral data. The overall mass window preferably comp... | 04/29/2008 |
| 7332087 | Flow sensing apparatus used to monitor/provide feedback to a split flow pumping system A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pu... | 02/19/2008 |
| 7309861 | Mass spectrometer A mass spectrometer is disclosed comprising a guide wire ion guide 1 having an outer cylindrical electrode 2 and an inner guide wire electrode 3. AC and DC potential differences are maintained between the outer electrode 2 and the inner e... | 12/18/2007 |
| 7297960 | Mass spectrometer A mass filter is disclosed comprising an orthogonal acceleration electrode 9. Ions entering the mass filter are orthogonally accelerated by the orthogonal acceleration electrode 9 in a primary acceleration region 2 and enter a flight region 3... | 11/20/2007 |
| 7294841 | Mass spectrometer An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising three co-axial capillary tubes 2,3,3′. A blue-flame gas torch 6 is provided downstream of the pr... | 11/13/2007 |
| 7294831 | MALDI sample plate A MALDI sample plate 1 is disclosed which comprises a metallic substrate 2 having a circular groove or moat 3. A hydrophobic polytetrafluoroethylene layer 4 is applied to the substrate 2 and a central portion 5 of the substr... | 11/13/2007 |
| 7265362 | Mass spectrometer An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising two co-axial capillary tubes 2,3. A blue-flame gas torch 6 is provided downstream of the probe ... | 09/04/2007 |
