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| Number | Title | Issue Date |
| 7713915 | Cytotoxic heteromeric protein combinatorial libraries A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit of a wild type heteromeric cytotoxic protein to create a library of mi... | 05/11/2010 |
| 7666646 | Crystal structure of human Pim-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design The present invention relates to the X-ray analysis of crystalline molecules or molecular complexes of human Pim-1. The present invention also relates to Pim-1-like binding pockets. The present invention provides a computer comprising a data storage medium encoded w... | 02/23/2010 |
| 7637809 | Systems and methods for providing a player's ticket Ticketing systems and methods are provided specifically relating to a player's ticket. A player's ticket references at least one player and allows the player's ticket holder to attend all sporting events played in by the at least one player referenced on the player'... | 12/29/2009 |
| 7634786 | Interactive television program guide system for determining user values for demographic categories An interactive television program guide system for determining user input values for demographic categories is provided. The system includes user television equipment having a receiver for receiving program guide information for the interactive television program gu... | 12/15/2009 |
| 7624410 | Program guide application interface system A program guide system is provided that supports a program guide application and multiple non-guide applications. The program guide system has a program guide application interface that allows the non-guide applications to use both device resources and program guide... | 11/24/2009 |
| 7457807 | Data migration and analysis A data migration technique presumes a schema suitable for combining disparate data sources in a business environment. This presumptive approach to data migration permits the development of rules and libraries specifically adapted to move data from various sources in... | 11/25/2008 |
| 7427665 | Chronic lymphocytic leukemia cell line A CLL line, CLL-AAT, and the preparation and characterization of antibodies using said cell line is disclosed. ... | 09/23/2008 |
| 7414111 | Engineered templates and their use in single primer amplification Methods of amplifying nucleic acid have now been discovered which include the steps of: a) annealing a primer to a template nucleic acid sequence, the primer having a first portion which anneals to the template and a second portion of predetermined sequence; b) synt... | 08/19/2008 |
| 7408041 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof Cancer treatments use a therapy that: 1) interferes with the interaction between CD200 and its receptor to block immune suppression thereby promoting eradication of the cancer cells; and 2) directly kills the cancer cells either by complement-mediated or antibody-de... | 08/05/2008 |
| 7371920 | Transgenic mouse model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 05/13/2008 |
| 7370380 | Mattress with removable top A mattress is constructed from a mattress body having an upper and a lower deck, which is preferably pervious to moisture and air. A removable panel, which includes a top layer of breathable fabric, a bottom layer of a fabric that forms a moisture barrier, and a bat... | 05/13/2008 |
| 7371570 | Cell-specific adenovirus vector comprising EBV-specific promoter Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing for transcriptional initiating regulation dependent upon transcripti... | 05/13/2008 |
| 7364727 | Metastatic colon cancer specific promoter and uses thereof Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to t... | 04/29/2008 |
| 7365189 | Nucleic acid molecules encoding enzymes from wheat which are involved in starch synthesis The present invention relates to nucleic acid molecules encoding enzymes which are involved in the starch synthesis in plants. These enzymes are starch synthases from wheat. The invention further relates to vectors and host cells containing said nucleic acid molecul... | 04/29/2008 |
| 7361492 | Crystal structure of aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto... | 04/22/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7319033 | Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and methods of use of such viruses are provided. These viruses comprise ... | 01/15/2008 |
| 7309906 | Apparatus and methods for providing highly effective and area efficient decoupling capacitance in programmable logic devices Improved decoupling capacitor designs and layout schemes are provided that generate high effective capacitance and high area efficiency at higher frequencies than that of previously known decoupling capacitor designs. The improved decoupling capacitor designs utiliz... | 12/18/2007 |
| 7306506 | In-situ chemical-mechanical planarization pad metrology using ultrasonic imaging Chemical-mechanical planarization (CMP) apparatus and methods for detecting polishing pad properties using ultrasonic imaging is presented. An ultrasonic probe assembly transmits ultrasonic signals onto the surface of a polishing pad during a CMP process. Reflected ... | 12/11/2007 |
| 7267815 | Methods and reagents for the enhancement of virus transduction in the bladder epithelium Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Altern... | 09/11/2007 |
| 7265587 | LVDS output buffer pre-emphasis methods and apparatus Methods and apparatus are provided for performing pre-emphasis of signals using buffer circuitry that is not dedicated to LVDS transmission. In an embodiment of the invention, pre-emphasis circuitry is provided to enable unused transistors of the buffer circuitry to... | 09/04/2007 |
| 7262634 | Methods of reducing power in programmable logic devices using low voltage swing for routing signals Reduced voltage swing signal path circuitry is provided that lowers the internal signaling power consumption of the interconnection resources of a programmable logic device. The reduced voltage swing signal path circuitry includes a reversed routing driver circuitry... | 08/28/2007 |
| 7252991 | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packagable vector transcripts are produced from high expression plasmids after stable or transient transfection in mammalian cells. High titers of recombinant retr... | 08/07/2007 |
| 7146630 | Broadband system with intelligent network devices Hybrid fiber/coax networks employ the existing cable plant used for cable TV and transmit data signals in a frequency bandwidth above that which is used for cable TV. As this cable plant was deployed in a tree and branch topology, data transmissions may be susceptib... | 12/05/2006 |
| 7067260 | Methods of identifying morphogen receptor-binding analogs Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors; (2) methods for producing receptor proteins, in... | 06/27/2006 |
| 6931211 | Reconfigurable data communications system with a removable optical backplane connector The present invention is directed to a reconfigurable data communications system. The system includes a removable optical backplane connector with a first end and a second end, a first data communications card, and a switch fabric card. The first data communications... | 08/16/2005 |
| 6901618 | Low profile mattress A low-profile mattress comprises an inner spring core having a plurality of spring coils and having an upper and lower surface. The mattress further includes a padding layer disposed on the upper surface and a quilting layer disposed over the padding layer and havin... | 06/07/2005 |
| 6900055 | Preparation of porous silicone rubber for growing cells or living tissue A method of making a silicone rubber having a structure adapted for growth of cells or living tissue, which comprises contacting a silicone rubber precursor with a biologically-acceptable sacrificial filler, curing the resultant mixture and removing the sacrificial ... | 05/31/2005 |
| D504761 | Shoe upper design | 05/10/2005 |
| 6887583 | Low pressure melamine/veneer panel A layered composite product for use as a floorboard, a door, a cabinet, a wall, etc. is disclosed. The product is a layered structure that includes a rigid substrate layer having two substantially planar sides, a resin-saturated sheet layer disposed on each of the s... | 05/03/2005 |
| 6884789 | Linear cyclodextrin copolymers Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclode... | 04/26/2005 |
| 6875428 | Lipase inhibiting polymers The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates... | 04/05/2005 |
| 6867216 | Inhibitors of hedgehog signal pathways, compositions and uses related thereto The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other sma... | 03/15/2005 |
| 6864089 | Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing This invention related to methods useful in the labeling of multiple polypeptide samples and subsequent analysis of these samples by mass spectrometry, particularly in the high throughput proteomic setting. ... | 03/08/2005 |
| D500855 | Low profile pneumatic walking brace | 01/11/2005 |
| D499533 | Footwear tread | 12/14/2004 |
| 6800603 | Morphogen-induced neural cell adhesion Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to m... | 10/05/2004 |
| D495420 | Shell for an ankle brace | 08/31/2004 |
| 6772530 | Mattress sizing and display apparatus Presently disclosed is a mattress cover that has marked upon it outlines of the various sizes of mattresses available for sale for use a sizing gauge or selling aid. A conventional mattress cover may be printed or embroidered with lines representing the various size... | 08/10/2004 |
| 6772463 | Perimeter stiffening system for a foam mattress A stiffening system for the perimeter edges of a foam core mattress comprising a coil spring (or other spring-based) structure disposed along one or more perimeter edges (e.g., one or both side edges, the foot, the head, or a combinations thereof including the foot ... | 08/10/2004 |
