Ropes & Gray - US Patent Attorneys and Agents

Attorney: Ropes & Gray

Number of patents: 84
Last date: December 30, 2008

Number	Title	Issue Date
7470783	Photocleavable protecting groups and methods for their use Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by phot...	12/30/2008
7122652	Polymorphisms in the human hPXR gene and their use diagnostic and therapeutic applications Described are general means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the hPXR gene. In particular, polynucleotides of mol...	10/17/2006
D497059	Multimedia desk	10/12/2004
6681406	Extendible belt A garment belt including an extendible insert. The insert may flex or stretch while the belt is being worn so that the belt adapts to variations in a wearer's waist size and shape....	01/27/2004
6638955	Antibiotic oxazolidinone derivatives The present application discloses a class of antibiotic compounds containing an oxazolidinone ring. These compounds have useful activity against Gram-positive pathogens including MRSA and MRCNS and, in particular, against various strains exhibiting resist...	10/28/2003
6617339	Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described....	09/09/2003
6613798	Small organic molecule regulators of cell proliferation The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiment...	09/02/2003
6611707	Microneedle drug delivery device Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tis...	08/26/2003
6608386	Sub-nanoscale electronic devices and processes A new class of electronic systems, wherein microelectronic semiconductor integrated circuit devices are integrated on a common substrate with molecular electronic devices....	08/19/2003
6605630	Antibiotic oxazolidinone derivatives The invention concerns a compound of the formula (I): ##STR1## wherein, for example: T is of the formula (IA), (IB), or (IC); ##STR2## R1 is of the formula --NHC(.dbd.O)Rb wherein Rb is (1-4C)alkyl; R2 and R	08/12/2003
6586181	Method for detecting allelic imbalance A method for detecting allelic imbalance (AI) in sample nucleic acid, which method comprises providing multiple copies of a target nucleic acid region present in the sample, the target nucleic acid region comprising a marker of heterozygosity, separating ...	07/01/2003
6584146	Systems and methods for wireless communications Systems and methods including a wireless communications device that consists of a collection of one or more processing elements, optionally forming a computer cluster, that together carry out the functions necessary to exchange information over a pluralit...	06/24/2003
6579683	Artery- and vein-specific proteins and uses therefor Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous ce...	06/17/2003
6576237	Vertebrate tissue pattern-inducing proteins, and uses related thereto The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatia...	06/10/2003
6569678	pRGR: a positive selection vector system for direct cloning of PCR amplified DNA fragments The present invention relates to the development of a positive selection vector based on insertional reconstruction of a reporter gene or of a regulatory gene controlling the expression of a reporter gene. The cloning vector carries a reporter gene or a r...	05/27/2003
6566067	High fidelity PCR cloning The present invention describes a methodology for generating high fidelity PCR products, and also cloning of such high fidelity PCR products in a suitable vector. Generation of polymerase-induced mutant fraction of target sequences during PCR amplificatio...	05/20/2003
6566054	Cyclin dependent kinase mutants, and diagnostic and therapeutic uses related thereto The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of mutant cyclin dependent kinase (CDK) proteins. These proteins fail to bind to CDK-inhibitory proteins and thus lead to aberrant cell growth. Herein, scree...	05/20/2003
6566048	Acetyl-COA-carboxylase from Candida albicans The Acetyl-COA-carboxylase (ACCase) gene from Candida albicans....	05/20/2003
6565843	Protein-induced tissue morphogenesis The invention provides methods, compositions and devices for inducing tissue-specific regeneration in a mammal, or for stimulating proliferation of mammalian progenitor cells. The present methods, compositions and devices make use of osteogenic protein 1 ...	05/20/2003
6565253	Watch light There is disclosed herein a watch that includes a steerable light. The light may be attached to a rotating bezel on the watch, or included in a crown or other moveable fixture of the watch, such that the light may be pointed independently from the orienta...	05/20/2003
6566469	Enzyme-mediated polymerization methods and products A method for polymerization of substituted ethylene monomers in an enzyme-mediated process is disclosed. The reaction proceeds under mild conditions with a wide variety of monomers, and is capable of producing stereoregular polymers. In certain embodiment...	05/20/2003
6561047	Method and system for analyzing motion transferred to a subject on a sleeping surface A method and system for analyzing the transfer of motion to a subject on a sleeping surface. A mattress is positioned on a frame, and a subject is positioned on the mattress. A sensor is placed in communication with the subject. The surface adjacent the s...	05/13/2003
6558662	Treatment of hematologic disorders The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of t...	05/06/2003
6557198	Mattress and bed assembly providing an enlarged sleeping surface area A bed assembly provides an enlarged sleeping surface area as compared to a standard Queen sized bed. Specifically, in the disclosed bed assemblies, the sleeping surface area is about 64 inches to about 68 inches wide and about 77 inches to about 82 inches...	05/06/2003
6552223	N-hydroxacylamino compounds, process for their preparation and pharmaceutical compositions containing them A compound of the formula (I): R1 --CO--N(OH)--CR2 R3 --CR4 R5 --CONH--CR6 R7 --CONR8 R9 (I) wherein: R1 is C1-6 alkyl, aryl or arylC1-6	04/22/2003
6551782	Patched genes and uses related thereto Methods for isolating patched genes, particularly mammalian patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of...	04/22/2003
6552016	Mediators of hedgehog signaling pathways, compositions and uses related thereto The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such ...	04/22/2003
6548736	7B2 knockout transgenic animals as models of endocrine disease In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human ma...	04/15/2003
6544782	pREM: a positive selection vector system for direct PCR cloning The present invention describes the development of a positive selection vector based on regulatory element modulation, wherein such modulation is achieved via insertional reconstruction or destruction of a regulatory element controlling transcription, tra...	04/08/2003
6545005	Mediators of hedgehog signaling pathways, compositions and uses related thereto The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growt...	04/08/2003
6532437	Crystalline frap complex The invention relates to the human protein FRAP, and in particular to the FKBP12-rapamycin binding domain thereof and to the ternary complex formed by the FRB domain, rapamycin and FKBP12. A new crystalline composition comprising the ternary complex, coor...	03/11/2003
6531445	Protein-induced morphogenesis in liver tissue Disclosed are 1) amino acid sequence data, structural features, homologies and various other data characterizing morphogenic proteins, 2) methods of producing these proteins from natural and recombinant sources and from synthetic constructs, 3) morphogeni...	03/11/2003
6524591	Monocyte locomotion inhibitory factor The invention relates to an anti-inflammatroy oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The oligopeptides are useful in treating inflammatory diseases when formulated in pharmaceutical...	02/25/2003
6520455	Method and apparatus for reducing turbulent drag The systems and methods of the invention include systems and techniques for controlling a turbulent boundary layer flow with a transverse traveling wave, oscillating at certain selected frequencies, amplitudes and wavelengths, to provide substantial reduc...	02/18/2003
6518308	Compositions for adhesion prevention Compositions and methods for the prevention of adhesion development involve the administration of therapeutic formulations of a halogenated organic compound to a patient in need of treatment. The formulations can include suitable carriers for optimal admi...	02/11/2003
6514753	Expression vectors for producing modified proteins Modified proteins, modified interferons ଱'s and ଲ's, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-଱-like proteins are provided which carry an identif...	02/04/2003
6514724	Hedgehog interacting proteins and uses related thereto The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as "hedgehog interacting proteins" or "HIPs", which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the...	02/04/2003
6509152	Immunosuppressant target proteins The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes....	01/21/2003
6506729	Methods and compositions for the treatment and prevention of Parkinson's disease Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating n...	01/14/2003
6503231	Microneedle device for transport of molecules across tissue Microneedle devices for transport of therapeutic and diagnostic materials and/or energy across tissue barriers, and methods for manufacturing the devices, are provided. The microneedles are hollow and/or porous and have diameters between about 10 nm and 1...	01/07/2003

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