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| Number | Title | Issue Date |
| 7785608 | Immunogenic compositions for the prevention and treatment of meningococcal disease The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that imm... | 08/31/2010 |
| 7754226 | Compositions and methods of use of ORF 554 from beta hemolytic streptococcal strains The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polype... | 07/13/2010 |
| 7045931 | Chip quartz oscillator and liquid-phase sensor The present invention relates to a chip quartz oscillator. In an embodiment of a chip quartz oscillator S in accordance with the present invention, a quartz oscillator 2, which has a detection electrode 3 on a surface thereof and a non-detection electr... | 05/16/2006 |
| 7537766 | inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof The present invention is directed to novel Neisseria meningitidis lipo-oligosaccharide inner core molecules, conjugates thereof and immunogenic compositions thereof. In particular embodiments, the invention relates to multivalent immunogenic compositions comp... | 05/26/2009 |
| 7384775 | open reading frames encoding polypeptide antigens and uses thereof The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae | 06/10/2008 |
| 7091317 | Fluorescent proteins The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The modified G... | 08/15/2006 |
| 7052839 | Terminal-phosphate-labeled nucleotides and methods of use The present invention describes methods of detecting a nucleic acid in a sample, based on the use of terminal-phosphate-labeled nucleotides as substrates for nucleic acid polymerases. The methods provided by this invention utilize a nucleoside polyphosphate, dideoxy... | 05/30/2006 |
| 7033762 | Single nucleotide amplification and detection by polymerase A method of characterizing a nucleic acid sample is provided that includes the steps of: (a) conducting a DNA polymerase reaction that includes the reaction of a template, a non-hydrolyzable primer, at least one terminal phosphate-labeled nucleotide, DNA polymerase,... | 04/25/2006 |
| 7026135 | Biotin-peg-substrate for a lipase assay Disclosed is a compound of Formula (I), wherein: L is a linking agent; B is a binding agent; X is an atom or group suitable for attaching L to the glycerol chain; and R is a straight chain saturated or unsaturated alkyl group having from 8 to 30 carbon atoms, substi... | 04/11/2006 |
| 7012136 | Stimulus responsive affinity chromatographic material and separation/purification method A separation material characterized by supporting, in its surface, a linear or crosslinked stimulus responsive polymer to which a substance A having specific affinity for a target substance and a low-molecular substance B having specific affinity for the substance A... | 03/14/2006 |
| 7008542 | Method for mixed mode adsorption Method for the removal of a substance from an aqueous liquid by ion exchange comprising providing a liquid with said substance is present; providing an adsorption matrix which comprises at least two different ligands; contacting the liquid with the matrix under a pe... | 03/07/2006 |
| 7005071 | Method of generating metal chelating affinity ligands The present invention relates to a method of generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of a) providing at least one cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile;... | 02/28/2006 |
| 6992303 | Detecting emitters of electromagnetic radiation, in particular fluorophore labeled substances The performance of devices for the detection of fluorophore labelled substances in an electrophoretic separation medium is improved by rescanning lines or pixels which caused saturation of an electromagnetic radiation detecting means (19) at a lower gain, the... | 01/31/2006 |
| 6990989 | Instrument treatment station An instrument treatment station includes a station body having a first and second elongate and spaced channel walls. The channel walls define an elongate instrument channel therebetween. The station body defines an elongate drain channel in fluid communication with ... | 01/31/2006 |
| 6986992 | P450 single nucleotide polymorphism biochip analysis This invention relates to methods and compositions for determining single nucleotide polymorphisms (SNPs) in P450 genes. In preferred embodiments, self extension of interrogation probes is prevented by using novel non self-extension probes and/or methods, thereby im... | 01/17/2006 |
| 6984733 | Manufacturing process for porous material A method for the manufacture of a solid porous separation material based on a polysaccharide, said method comprising the steps of: (a) providing an aqueous solution (I) of a polysaccharide, (b) solidifying the solution, preferably by transforming the solution to a g... | 01/10/2006 |
| 6969045 | Rotary valve The present invention relates to valves with small dead volumes. A valve in accordance with the present invention has a ferrule (7) which receives a plurality of fluid lines (33) which lead to outlets on an end surface (25) of said ferrule (7... | 11/29/2005 |
| 6955462 | Mixing chamber An apparatus is provided for mixing and maintaining particulates in liquid suspension, the apparatus comprising a reservoir for holding a fluid containing dispersed particles, a substantially horizontally-disposed mixing plate mounted inside the reservoir, the mixin... | 10/18/2005 |
| 6956077 | Temperature-responsive polymer compound and process for producing the same A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided. ... | 10/18/2005 |
| 6943242 | Design of artificial genes for use as controls in gene expression analysis systems Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from inter- or intragenic regions of a genome. T... | 09/13/2005 |
| 6936166 | Endpiece for a chromatography column A liquid transfer system (100) comprising a net (170) and a net support (160), wherein, the net (170) is integrally joined with the net support (160). The net (170) and the net support (160) are preferably joined by w... | 08/30/2005 |
| 6927045 | Methods and apparatus for template capture and normalization for submicroliter reaction Methods for preparing nanoscale reactions using nucleic acids are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is performed di... | 08/09/2005 |
| 6921638 | Hydrogel-based microarray signal amplification methods and devices therefor Methods and devices for detecting nucleic acid and protein targets on hydrogel microarrays are disclosed. Fluorophores are incorporated into the targets and detected. A linear correlation between target concentration and signal amplitude is maintained through the el... | 07/26/2005 |
| 6919186 | Fluorescent proteins The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The modified G... | 07/19/2005 |
| 6916919 | Isolation of DNA molecules The present invention relates to a process for separating nucleic acid molecules, preferably open circular and supercoiled plasmid DNA and RNA molecules from each other, comprising the steps of providing a solution comprising the molecules; adsorbing the molecules t... | 07/12/2005 |
| 6913935 | Multiple assay method A method for the assay of N samples each containing a compound to be tested, comprises providing N reaction vessels each containing a population of carrier beads and other reagents for performing the assay, where N is at least 2 e.g. 80-4000. Each population of carr... | 07/05/2005 |
| D506261 | Chromatography column locking ring | 06/14/2005 |
| 6905595 | Scalable liquid distribution system for large scale chromatography columns A uniform fluid distribution system (2) for use with a liquid transfer system (100) for maintaining an interface between liquid phases within a large scale separator system including a cell into which liquid may be introduced as discrete phases at an i... | 06/14/2005 |
| 6887990 | Method for deprotecting oligonucleotides A method for purifying an oligonucleotide that comprises providing an oligonucleotide attached to a substrate, wherein the oligonucleotide contains phosphate protecting groups; contacting the oligonucleotide with a reagent, e.g., an organic amine, that cleaves the p... | 05/03/2005 |
| 6875573 | DNA polymerases having amino acid substitutions and homologs thereof Thermostable DNA polymerases both in native form and having single amino acid substitutions and optionally N-terminal deletions are disclosed. These polymerases exhibit a substantial improvement of DNA sequencing performance compared to Taq DNA polymerase. The insta... | 04/05/2005 |
| 6870185 | Integrated microchip design Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical c... | 03/22/2005 |
| 6855503 | Heterocyclic FRETdye cassettes for labeling biological molecules and their use in DNA sequencing Exploitation of suitably functionalized heterocyclic molecules, in the design and synthesis of Fluorescence Resonance Energy Transfer (FRET) cassettes and their corresponding dideoxynucleotide terminators culminated into efficient reagents for DNA sequencing. Additi... | 02/15/2005 |
| 6852230 | Method for the manufacture of compositions containing low concentrations of salts Method for desalting an aqueous liquid containing a charged substance comprising the steps of: (i) contacting liquid (I) with an ion-exchanger (1) under conditions permitting binding between ion-exchanger and substance, said ion-exchanger comprising a base matrix ca... | 02/08/2005 |
| 6847035 | Devices and methods for the detection of particles The present invention relates to devices and methods for determining the masses of particles by measuring the time between a first event such as a sample (5) being ionized, (or a beam of electromagnetic radiation being scattered by a particle (15) and ... | 01/25/2005 |
| 6843427 | Method and device for producing a coherent layer of even thickness of liquid or melt on a rotating disk Method and device for continuously producing a coherent layer of a liquid/melt of even thickness by means of centrifugal action along the entire periphery of a rotating disk (13, 113), liquid/melt being supplied to the disk around its entire axis of rotation ... | 01/18/2005 |
| D500856 | Chromatography column assembly | 01/11/2005 |
| 6841097 | Method of producing porous spherical particles The invention refers to a method of controlling the porosity of porous spherical particles produced from a polysaccharide dissolved in a solvent, in which it can be gelled. The polysaccharide solution is finely divided by mechanical means into spherical droplets whi... | 01/11/2005 |
| D500555 | Chromatography column end cap | 01/04/2005 |
| 6835379 | Method of producing IgG A method for producing IgG from plasma for medical applications, comprising at least: (i′) removal of albumin resulting in an IgG fraction, (ii′) purifying IgG from an IgG fraction, which is derived from the IgG fraction obtained in step (i′), by adsorbing IgG... | 12/28/2004 |
