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| Number | Title | Issue Date |
| 8097733 | Pyrazole derivatives as 5-LO-inhibitors The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same. ... | 01/17/2012 |
| 8097621 | Pyrazolo[4,3-d]pyrimidines as phosphodiesterase inhibitors This invention relates to compounds of formula (I) ... | 01/17/2012 |
| 8076356 | Triazolopyridinylsulfanyl derivatives as P38 map kinase inhibitors A compound of formula (I), or a pharmaceutical acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p3... | 12/13/2011 |
| 8067589 | Heterocyclic compounds useful in treating diseases and conditions The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of su... | 11/29/2011 |
| 8044052 | Biaryl ether urea compounds The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions c... | 10/25/2011 |
| 8013019 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 09/06/2011 |
| 7943628 | Pyrimidine derivatives A compound of Formula (I): or a pharmaceutically and/or veterinarily acceptable derivative thereof, wherein R1, R2, R3, R4, R5, and R8 are as defined above. ... | 05/17/2011 |
| 7906548 | Methods for the use of inhibitors of cytosolic phospholipase A2 This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibito... | 03/15/2011 |
| 7906536 | Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide This invention is directed generally to processes for the preparation of compounds of Formula I: wherein R2, R3, R4, R5, X1, X2, X3, X4... | 03/15/2011 |
| 7902373 | Nicotinamide derivatives The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of su... | 03/08/2011 |
| 7902195 | Pyridine [3,4-b] pyrazinones Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined i... | 03/08/2011 |
| 7842837 | Process for the synthesis of C-2, C-3 substituted N-alkylated indoles useful as cPLAinhibitors The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: ... | 11/30/2010 |
| 7842834 | Process for the synthesis of sulfonyl halides and sulfonamides from sulfonic acid salts The present invention provides synthetic processes for the preparation of sulfonyl halides of Formula Ar—(R)z—SO2—X and sulfonamides of Formula Ar—(R)z—SO2—NR4R5, where the constituent var... | 11/30/2010 |
| 7842715 | N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor. ... | 11/30/2010 |
| 7820825 | N-substituted-azacyclylamines as histamine-3 antagonists The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor. ... | 10/26/2010 |
| 7812040 | Histamine-3 receptor antagonists This invention is directed to a compound of the formula Ia or Ib, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated ... | 10/12/2010 |
| 7803825 | Aminoalkylazole derivatives as histamine-3 antagonists The present invention provides a compound of formula Ia: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor. ... | 09/28/2010 |
| 7772269 | Pyrazole analogs The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparatio... | 08/10/2010 |
| 7772223 | Carboxamide derivatives as muscarinic receptor antagonists The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them. ... | 08/10/2010 |
| 7767715 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 08/03/2010 |
| 7754892 | Processes for the preparation of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxamide Provided are processes for the preparation of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxamide, a compound useful for the treatment of endothelin-mediated disorders. ... | 07/13/2010 |
| 7629363 | Diaryl substituted pyridinones Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compou... | 12/08/2009 |
| 7629358 | Compounds useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 12/08/2009 |
| 7612084 | Amine derivatives for the treatment of asthma and COPD The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 11/03/2009 |
| 7582643 | Heterocyclic compounds useful in treating diseases and conditions The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of su... | 09/01/2009 |
| 7579340 | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use. ... | 08/25/2009 |
| 7572799 | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors This invention relates to compounds of formula (I) ... | 08/11/2009 |
| 7569572 | Pyrazolo[4,3-D]pyrimidines This invention relates to compounds of formula (I). ... | 08/04/2009 |
| 7557121 | Tetrahydronaphthyridine derivatives The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I): or of the general formula (I′) in which A and R1 are as defined withi... | 07/07/2009 |
| 7547731 | Formamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 06/16/2009 |
| 7538141 | Compounds for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 05/26/2009 |
| 7528170 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 05/05/2009 |
| 7511057 | Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors A compound of formula (I), or a pharmaceutically acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a ... | 03/31/2009 |
| 7482487 | Phenylaminoethanol derivatives as β2 receptor agonists The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous di... | 01/27/2009 |
| 7482022 | Palatable chewable tablet A palatable chewable tablet is described herein for oral administration of cetirizine dihydrochloride. The formulation is made more palatable by incorporating a combination of a grape flavoring agent with a vanilla flavoring agent. ... | 01/27/2009 |
| 7439397 | Phenol derivative The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide. ... | 10/21/2008 |
| 7375100 | 2-amino-pyridine derivatives useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 05/20/2008 |
| 7351742 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 04/01/2008 |
| 7321040 | Triazolo-pyridines as anti-inflammatory compounds The present invention relates to novel triazolo-pyridines of the formula wherein X is >CH2, >NH, sulfur, >S═O, >SO2 or oxygen; wherein said >CH2 and >NH may optionally be substi... | 01/22/2008 |
| 7300771 | Process to produce 19-nor-10β-carboxylic acids by fungal oxidation of 6-substituted-Δ6-pregnanes A process to produce 19-nor-10β-carboxylic acids by fungal oxidation of 6-substituted-Δ6-pregnanes is disclosed. ... | 11/27/2007 |
