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Attorney: Rodney; Burton


Number of patents: 665
Last date: January 31, 2012

          9            
NumberTitleIssue Date
4735795Alkylammonium complexes of diatrizoic acid as X-ray contrast agents
New X-ray contrast agents are provided which are alkylammonium complexes of diatrizoic acid having the structure ##STR1## X-ray contrast medium containing the above X-ray contrast agent and a carrier therefor such as a liposome carrier, and a method ...
04/05/1988
47359627-thiabicycloheptane substituted diamide and its congener prostaglandin analogs
7-Thiabicycloheptane substituted diamide and congener prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 1 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; R is CO2 H, CO
04/05/1988
4734508Process and intermediates for preparing 4-substituted proline derivatives
A process is provided for preparing 4-hydroxy-4-phenyl-proline derivatives of the structure ##STR1## wherein R1 is a nitrogen protecting group such as benzoyl, benzyloxycarbonyl, t-butoxycarbonyl, benzyl, benzhydryl, trityl, acetyl, t...
03/29/1988
4734424Bicycloheptane substituted diamide and its congener prostaglandin analogs
Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2 --, ##S...
03/29/1988
47344265,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs
5,6-Epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; R is CO2 H, CO2 alkyl, ...
03/29/1988
47344257-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs
7-Oxabicycloheptane substituted hydroxamic acid prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH2 -CH2 --; n is 1 to 5; R is CO2 H, CO2 alkyl, CO
03/29/1988
4728670Biphenyl hydroxamic acids
Biphenyl hydroxamic acids are provided having the structure ##STR1## wherein m is 1 to 7, X is S, O or NH, R is H, lower alkyl, aryl, aralkyl or cycloalkyl and R1 is H, lower alkyl, aryl, aralkyl, cycloalkyl, alkanoyl or aroyl. These compo...
03/01/1988
4725440Antifungal pastille formulation and method
An antifungal pastille formulation, preferably containing nystatin as the antifungal agent, is provided which is soft and smooth in texture and when dissolved slowly in the mouth does not cause irritation of and will not adhere to oral mucosa and yet dist...
02/16/1988
4721725Aryl-cycloalkyl[b]pyrrole derivatives
Aryl-cyclopenta- and arylcyclohexa[b]pyrrole derivatives are provided having the structure ##STR1## wherein n is 1 or 2; X is --OR1 or --NR2 R3 wherein R1 is H, lower alkyl, cycloalkyl, aryl, aralkyl or cyc...
01/26/1988
4714714Arachidonic acid analogs
Analogs of arachidonic acid are provided having the structure ##STR1## wherein R is CH2 OH or CO2 H and m is 1 or 2. These compounds are useful as inhibitors of leukotriene and prostaglandin biosynthesis and as such are useful a...
12/22/1987
4711900Certain arylalkyl or pyridylalkyl hydroxamates useful for treating allergies and asthma
Arylhydroxamates are provided having the structure ##STR1## wherein R1 is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkyl, or aralkyl; R2 is hydrogen, lower alkyl, aryl, cycloalkyl, alkanoyl or aroyl; m is 2 to 8; and ##S...
12/08/1987
4703043Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents....
10/27/1987
4687865Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
A process is provided for preparing a 7-oxabicycloheptane amino alcohol intermediate of the general structure ##STR1## (wherein the above structures represents (D) or (L) isomers) which is useful in preparing thromboxane A2 receptor antago...
08/18/1987
4673685Hydroximic acids of 7-oxabicycloheptane substituted ethers and thioethers useful in the treatment of thrombotic disease
Hydroximic acids of 7-oxabicycloheptane substituted ether and thioether prostaglandin analogs are provided having the structural formula ##STR1## wherein Y is O or ##STR2## and including all stereoisomers thereof. The compounds are inhibitors of...
06/16/1987
46704537-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of thrombotic disease
7-Oxabicycloheptane substituted amidocarbamoyl prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; R1 is CO2 H, ...
06/02/1987
4670193Process for preparing phosphonic acids
A process for preparing phosphonic acids of the structure ##STR1## wherein R1 is lower alkyl, aryl, cycloalkyl or arylalkyl, and R2 is H, benzyl or ##STR2## by oxidizing the corresponding phosphonous acid ##STR3## ...
06/02/1987
4666705Controlled release formulation
A controlled release pharmaceutical formulation which undergoes slow release of active drug is provided, preferably in the form of a tablet containing medicament, such as captopril, is slowly released over a controlled length of time. The tablet also incl...
05/19/1987
46633367-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease
7-Oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2 --, ...
05/05/1987
46633377-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease
7-Oxabicycloheptane substituted amides are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; R is CO2 H, CO2 alkyl, CO2 alkal...
05/05/1987
46615067-oxabicycloheptane substituted ox prostaglandin analogs
7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is --CH.dbd.CH-- or --(CH2)2 --,...
04/28/1987
46561857-oxabicycloheptane substituted aminoalkyl amide prostaglandin analogs
7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; R is CO2 H, CO2
04/07/1987
4654367Hydroxamic acids of 7-oxabicycloheptane substituted ethers useful as anti-allergy and anti-inflammation agents
Hydroxamic acids of 7-oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein Q is --CH2 --A--(CH2)n --; X is S or O, Y is O or ##STR2## and including...
03/31/1987
4654364Hydroxamic acids of 7-oxabicycloheptane substituted ethers
Hydroxamic acids of 7-oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein Y is O or ##STR2## and including all stereoisomers thereof. The compounds are inhibitors of Ɗ5...
03/31/1987
46543577-oxabicycloheptane substituted sulfonamide prostaglandin analogs
7-Oxabicycloheptane substituted sulfonamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2 -...
03/31/1987
46543567-oxabicycloheptane substituted diacid diamide prostaglandin analogs
7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2
03/31/1987
46543557-oxabicycloheptane substituted amide-thioamide prostaglandin analogs
7-Oxabicycloheptane substituted amide-thioamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2...
03/31/1987
4654366Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ethers useful as anti-thrombotic agents
7-Oxabicycloheptane substituted ether or thio ether prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or ##STR2## and X is O or ##STR3## and including all stereoisomers thereof. The compounds are ...
03/31/1987
46525787-oxabicycloheptane substituted amide prostaglandin analogs
Cis-exo 7-oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; R is CO2 H, CO2 alkyl, CO
03/24/1987
46525767-oxabicycloheptane substituted amide-carbamate prostaglandin analogs
7-Oxabicycloheptane substituted amide-carbamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2
03/24/1987
4647585Bicycloheptane substituted ethers
Bicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein X is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in t...
03/03/1987
46475737-oxabicycloheptane substituted thioamide-amide prostaglandin analogs
7-Oxabicycloheptane substituted thioamideamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2
03/03/1987
46394617-oxabicycloheptane substituted keto-amide prostaglandin analogs useful in the treatment of thrombotic disease
7-Oxabicycloheptane substituted keto-amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2 --...
01/27/1987
46380127-oxabicycloheptane ଱-substituted ketone prostaglandin analogs useful in the treatment of thrombotic disease
7-Oxabicycloheptane ଱-substituted ketone prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; X is halogen, alkanoyloxy or hydrox...
01/20/1987
4638011Tetrahydrothienyl substituted prostaglandin analogs
Tetrahydrothienyl substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease....
01/20/1987
46329317-oxabicycloheptane substituted amide-sulfonamide prostaglandin analogs useful in the treatment of thrombotic disease
7-Oxabicycloheptane substituted amide-sulfonamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH2 --CH2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH2
12/30/1986
4627973Skin mousse
A skin and/or fragrance mousse or foam is provided which is in the form of a light airy stable foam which does not readily break down, and which contains a unique combination of three moisturizers, an alkoxylated methyl glucose derivative such as polyprop...
12/09/1986
46265487-oxabicycloheptane substituted prostaglandin compounds useful in the treatment of thrombotic disease
7-Oxabicycloheptane substituted prostaglandin alcohols are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or (CH2)2 ; m is 1 to 5; Q is --CH.dbd.CH-- or (CH2)2 ; R is H, alkali m...
12/02/1986
4618583Method of preparing L-(+)-ଲ-hydroxyisobutyric acid by fermentation
A method is provided for preparing L-(+)-ଲ-hydroxyisobutyric acid by fermentation employing microorganisms of the species Pseudomonas aeruginosa and of the genus Protaminobacter such as of the species Protaminobacter alboflavus, and isobutyric acid ...
10/21/1986
4616005Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents....
10/07/1986
46148257-oxabicycloheptane and 7-oxabicycloheptene compounds
7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolyt...
09/30/1986
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