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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 5099035 | Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same Mevinic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy-2-methyl)-substituted-decahydronapht halene esters and have the structure ##STR1## wherein Z is ##STR2## wherein R is alkali metal such as Na, or H or lowe... | 03/24/1992 |
| 5098889 | Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors A method is provided for imhibiting loss of cognitive functon, including memory, which may or may not be associated with Alzheimer's disease, by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a ... | 03/24/1992 |
| 5097043 | Process of preparing captopril An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R1 are independently H, lower alkyl or halogen... | 03/17/1992 |
| 5095136 | Method for preparing isoprenoid cyclopropane 1,1-dicarboxylates and derivatives thereof and novel intermediates A process is provided for preparing isoprenoid cyclopropane 1,1-dicarboxylates and derivatives thereof including the corresponding monocarboxylate, monocarboxylic acid and alcohol derivatives thereof, all of which are useful in preparing squalene syntheta... | 03/10/1992 |
| 5093129 | Method for treating addiction to a drug of abuse employing an ACE inhibitor A method is provided for treating addiction to a drug of abuse such as nicotine, cocaine or diazepam, by inhibiting appetitie or desire for such drug by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or SQ 29,852, alone or in co... | 03/03/1992 |
| 5091378 | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesteroleumic agents are provided which have the structure ##STR1## wherein R is OH, or salts thereof or lower alkoxy; Rx is H or alkyl; X is --CH2 | 02/25/1992 |
| 5089502 | Method for preventing or treating anxiety employing a calcium channel blocker A method is provided for inhibiting onset of or treating anxiety by administering a calcium channel blocker such as diltiazem or nifedipine, over a prolonged period of treatment.... | 02/18/1992 |
| 5070099 | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use Arylthioalkylphenylcarboxylic acids are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, X is COOR where R is hydrogen, alkali metal, or... | 12/03/1991 |
| 5066480 | Method of preventing or reducing adverse reactions to protamine using a thromboxane A2 receptor antagonist A method is provided for preventing reducing or reversing adverse reactions, such as pulmonary hypertension produced when protamine interacts with heparin, by administering a thromboxane A2 receptor antagonist.... | 11/19/1991 |
| 5061694 | Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor A method is provided for slowing the progression of atherosclerosis in coronary arteries in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients in a mammalian species by administering an ACE inhibitor... | 10/29/1991 |
| 5049553 | Method for preventing or treating symptoms resulting from closed head injuries employing an ace inhibitor A method is provided for preventing onset of or treating symptoms resulting from closed head injuries, in hypertensive or normotensive patients, by administering an ACE inhibitor, for example captopril, zofenopril, fosinopril, ceranapril, enalapril or lis... | 09/17/1991 |
| 5049394 | Pharmaceutical composition containing high drug load and method for preparing same A pharmaceutical composition in the form of beads prepared by an extrusion-spheronization technique and containing more than 80% by weight drug, less than 15% by weight non-lipophilic binder-plasticizer, such as microcrystalline cellulose to achieve requi... | 09/17/1991 |
| 5047549 | Derivatives of pravastatin for inhibiting cholesterol biosynthesis Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the struc... | 09/10/1991 |
| 5037821 | Method for inhibiting loss of cognitive functions employing a calcium channel blocker alone or in combination with an ACE inhibitor A method is provided for inhibiting loss of cognitive function, including memory, which may or may not be associated with Alzheimer's disease, in a mammalian species by administering a benzazepine-type or a pyrimidine-type calcium channel blocker such as ... | 08/06/1991 |
| 5032578 | Method for preventing or treating depression employing a combination of an ace inhibitor and a drug that acts at serotonin receptors A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a drug that acts at serotonin receptors such as zacopride, over a prolonged ... | 07/16/1991 |
| 5030447 | Pharmaceutical compositions having good stability A pharmaceutical compositions is provided which has excellent stability, when dispersed in water has a pH of at least about 9, and includes a medicament which is sensitive to a low pH environment such as pravastatin, one or more fillers such as lactose an... | 07/09/1991 |
| 5030648 | Combination and method for treating obsessive-compulsive disorder, and motor and phonic tics in Tourettes' syndrome using such combination A new combination of drugs is provided which is formed of an angiotensin converting enzyme inhibitor such as ceranapril or captopril, and a dopaminergic receptor blocker which is preferably pimozide and a method for treating obsessive-compulsive disorder ... | 07/09/1991 |
| 5025017 | Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates Seco-mevinic acid derivatives are provided which has the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroar... | 06/18/1991 |
| 5025003 | Isoprenoid phosphinylformic acid squalene synthetase inhibitors Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthetis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents, are provided which have the structure ##STR1## wherein R | 06/18/1991 |
| 5025000 | Phosphorus-containing HMG-CoA reductase inhibitor compounds Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH, or lower alkoxy; Rx is H or alkyl; X is --(CH | 06/18/1991 |
| 5017716 | Phosphorous-containing HMG-CoA reductase inhibitors, new intermediates and method Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH, lower alkoxy or lower alkyl; Rx is H or al... | 05/21/1991 |
| 5015633 | Method for inhibiting loss of cognitive functions employing an ace inhibitor A method is provided for inhibiting loss of cognitive function, including memory, which may or may not be associated with Alzhemier's disease, in a mammalian species by administering an ACE inhibitor, which is a phosphonate substituted amino or imino acid... | 05/14/1991 |
| 5006542 | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use Arylthioalkylphenylcarboxylic acids are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, X is COOR where R is hydrogen, alkali metal, or... | 04/09/1991 |
| 5001251 | Optical resolution of DL-3-acylthio-2-methylpropanoic acid An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R1 are independently H, lower alkyl or halogen... | 03/19/1991 |
| 4981794 | Method of preparing D(-)-ଲ-hydroxyisobutyric acid by fermentation A method is provided for preparing D(-)-ଲ-hydroxyisobutyric acid by fermentation employing the method and/or ethyl esters of isobutyric acid, the methyl and/or ethyl esters of methacrylic acid, isobutyl isobutyrate and/or isobutyl methacrylate as th... | 01/01/1991 |
| 4977174 | 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease 7-Oxabicycloheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula ##STR1## wherein m is 0, 1, 2, 3 or 4; n is 1, 2 or 3; and p is 1, 2 or 3; Z is --CH... | 12/11/1990 |
| 4977145 | Method for preventing or treating depression employing an ace inhibitor A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1-oxohexyl]-L-pr oline, fosinopril or zofenopril, alone or in combination with an ... | 12/11/1990 |
| 4975461 | P-aminophenols, derivatives thereof and method of use p-Aminophenols are provided having the structure ##STR1## wherein m is 0, 1 or 2; n is 0, 1, 2 or 3; R1 and R2 may be the same or different and are H, hydroxy or alkoxy; R3 is H, lower alkyl, alkanoyl or aroyl and R | 12/04/1990 |
| 4975279 | Method of improving post-ischemic myocardial function using a thromboxane A2 antagonist in combination with a thrombolytic agent and combination A method is provided for improving post-ischemic myocardial function such as contractile dysfunction or reperfusion injury by administering a thromboxane receptor antagonist which is a 7-oxabicycloheptane substituted diamide prostaglandin analog in combin... | 12/04/1990 |
| 4970221 | 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same 3,5-Dihydroxypentanoic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy-2-methyl)-substituted-thiazolidine derivatives and have the structure ##STR1## wherein Z is ##STR2## R6 is an alkali metal, lowe... | 11/13/1990 |
| 4959383 | Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use Phenylsulfone alkenoic acids and derivatives thereof are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, X is COOR wherein R is hy... | 09/25/1990 |
| 4958036 | Enantiomerically selective synthesis of certain N-substituted-2-(carbamyl 7-oxabicyclo[2.2.1]heptane-3-carboxylic acids A process is provided for preparing a 7-oxabicycloheptane amino alcohol intermediate of the general structure ##STR1## (wherein the above structures represents (D) or (L) isomers) which is useful in preparing thromboxane A2 receptor antagonists... | 09/18/1990 |
| 4948580 | Muco-bioadhesive composition A bioadhesive composition is provided which may be employed as an oral drug delivery system and includes a freeze-dried polymer mixture formed of the copolymer poly(methyl vinyl ether/maleic anhydride) and gelatin, which is dispersed in an ointment base s... | 08/14/1990 |
| 4937355 | Process for preparing (trans)-4-substituted-dl-proline derivatives A process is provided for preparing (trans)-4-phenyl-DL-proline derivatives, which are useful in preparing certain angiotensin converting enzyme inhibitors, which process involves reacting an ester of the structure ##STR1## wherein X is a leavin... | 06/26/1990 |
| 4931460 | Post-ischemic myocardial dysfunction using thromboxane A2 antagonists A method is provided for improving post-ischemic myocardial dysfunction such as contractile dysfunction or reperfusion injury by administering a thromboxane A2 antagonist before, during or immediately after an ischemic attack.... | 06/05/1990 |
| 4931430 | Method for preventing or treating anxiety employing an ACE inhibitor A method is provided for inhibiting onset of or treating anxiety by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or SQ 29,852, alone or in combination with a calcium channel blocker such as diltiazem or nifedipine, over a prol... | 06/05/1990 |
| 4925873 | Method of treating skin injuries using thromboxane A2 receptor antagonists A method for treating skin injuries is provided by administering a thromboxane A2 receptor antagonist systemically or topically to the skin area to be treated.... | 05/15/1990 |
| 4924024 | Phosphorus-containing squalene synthetase inhibitors, new intermediates and method Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## wherein Q is ##STR2## or a bond; Z is --(CH2)n -- or --(CH2 | 05/08/1990 |
| 4912096 | Method for preventing or treating depression employing an ace inhibitor A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1-oxohexyl]-L-pr oline, fosinopril or zofenopril, alone or in combination with an ... | 03/27/1990 |
| 4912231 | Process for preparing (trans)-4-phenyl-L-proline derivatives A process is provided for preparing (trans)-4-phenyl-L-proline derivatives with excellent stereospecificity, which are useful in preparing certain ACE inhibitors, which process involves reacting a proline derivative of the structure ##STR1## whe... | 03/27/1990 |
