Did You Know...
...that the Band-Aid Bandage was invented by a Johnson & Johnson employee whose wife had cut herself? Earl Dickson's wife was rather accident prone, so he set out to develop a bandage that she could apply without help. He placed a small piece of gauze in the center of a small piece of surgical tape, and what we know today as the Band Aid bandage was born!
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| Number | Title | Issue Date |
| 7057046 | Lactam glycogen phosphorylase inhibitors and method of use A compound of formula I wherein W is a bicyclic hetroaryl of the structure ... | 06/06/2006 |
| 7053106 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R3, Y, x, m, and n are... | 05/30/2006 |
| 7030253 | Process for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs and novel intermediates A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an electrophilic protecting group, such as benzoyloxycarbonyl, and converting the C-... | 04/18/2006 |
| 7026143 | Enzymatic resolution of aryl and thio-substituted acids Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 t... | 04/11/2006 |
| 7015219 | 3-aryl-hydroxybenzoxazines and 3, 4-dihydro-3-aryl-hydroxybenzoxazines as selective estrogen receptor beta modulators Substituted benzoxazine and 3,4-dihydrobenzoxazine derivatives possessing activity as estrogen receptor beta (ERβ) modulators are provided which have the structure of formula I wherein the subs... | 03/21/2006 |
| 6995181 | Modulators of the glucocorticoid receptor and method Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the s... | 02/07/2006 |
| 6979691 | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, in which E is X is N or CH, W is —NR16R17, —NR16C(═O)R22 | 12/27/2005 |
| 6949642 | Production of tertiary amines by reductive amination A process for the production of tertiary amines by reductive amination of carbonyl compounds with secondary amines in the presence of a water scavenger, preferably trifluoroacetic acid anhydride, is disclosed. This process has applications in the preparation of imid... | 09/27/2005 |
| 6936590 | C-aryl glucoside SGLT2 inhibitors and method A method is provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of a compound of the formula alone or in combination with one or more other antidiabetic agent(s) or other therapeuti... | 08/30/2005 |
| 6887870 | Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, a... | 05/03/2005 |
| 6875867 | Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors A process is provided for preparing chiral diol sulfones of the structure where R3 is preferably where R4a is preferably aryl such as phenyl, and R | 04/05/2005 |
| 6830760 | Glyburide composition The present invention relates to a physical form of the known drug substance glyburide, also known as glibenclamide, and chemically defined as 5-chloro-N-[2-[4-[[[(cyclohexylamino)-carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide (Merck Index, Tenth Edition,... | 12/14/2004 |
| 6812345 | HMG-CoA reductase inhibitors and method Compounds of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids such as lowering LDL cholesterol and/or increasing HDl cholesterol, and treating hyperlipidemia, hyperchol... | 11/02/2004 |
| 6800605 | Aniline-derived ligands for the thyroid receptor New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH2—, —CO—, or —NH—; Y is —(CH2)n— where n is an i... | 10/05/2004 |
| 6777550 | N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors N-formyl hydroxylamines are provided which have the structure wherein R is H, alkyl, alkenyl, aryl-(CH2)p—, heteroaryl-(CH2)p— or cycloheteroalkyl-(CH2)p | 08/17/2004 |
| 6727271 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, a... | 04/27/2004 |
| 6713487 | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same Compounds having the formula (I), —NR11R12; G is a novel side chain selected from C2-6alkenyl, A3-aryl, —OR18, heteroaryl, A1-cyano, A2—O... | 03/30/2004 |
| 6713471 | Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, ... | 03/30/2004 |
| 6673815 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure ##STR1## wherein Q is C or N, X1 is CH or N and, A, E, M, G, X2, X3, X4, R1, R2, R2a, R2b, R2c, R3, Y,... | 01/06/2004 |
| 6653314 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure ##STR1## wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein... | 11/25/2003 |
| 6649187 | Use of polyalkylamine polymers in controlled release devices The invention provides a method and device for administering an amine drug, such as [S-(R,S)]-2-[4-[[(4-methyl)piperazin-1-yl]carbonyl]phenoxy]-3,3-diethyl-N- [1-(3,4-methylenedioxyphenyl)butyl]-4-oxo-1-azetidinecarboxamide), in a sustained release do... | 11/18/2003 |
| 6627636 | HMG-CoA reductase inhibitors and method Compounds of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids such as lowering LDL cholesterol and/or increasing HDl cholesterol, and treating hyperlipidemia... | 09/30/2003 |
| 6624309 | Benzoic acid derivatives and related compounds as antiarrhythmic agents Benzoic acid derivatives of the formula ##STR1## where X is oxygen, sulfur, --NH, --NR1, --N--CN, --N--OR1 or --N--NO2 ; Y is a single bond, --C.dbd.C--, or --NH; R1 is alkyl, alkenyl, alkynyl, aryl, cycl... | 09/23/2003 |
| 6620821 | HMG-CoA reductase inhibitors and method Compounds of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlip... | 09/16/2003 |
| 6573287 | 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula ##STR1## where n is 0 or 1; X is H or CN; Y is N, NH or O; Z is CH2 when Y is O or N--H, with Y--Z forming a single bond, and Z is CH when Y is N, with Y--Z for... | 06/03/2003 |
| 6534536 | Alkylsulfonamido heterocyclic thrombin inhibitors Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl, aminoalkyl, alkyl, cycloalkyl, amidoalkyl, ... | 03/18/2003 |
| 6511977 | Potassium channel inhibitors and method Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds are ... | 01/28/2003 |
| 6509348 | Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination A method is provided for inhibiting platelet aggregation and thrombus formation by administering to a patient an ADP-receptor blocking antiplatelet drug, such as clopidogrel, in combination with a thromboxane A2 receptor antagonist, such as ife... | 01/21/2003 |
| 6509330 | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors Hydroxamic acids are provided which are ACE and/or NEP inhibitors and have the structure ##STR1## wherein R*, R and R1 are as defined herein and A is a dipeptide preferably derived from an amino acid, or is a conformationally restricted di... | 01/21/2003 |
| 6472427 | Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile The (R)-enantiomer of 4-[[(cyanoimino)[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness.... | 10/29/2002 |
| 6458835 | Method of inhibiting or treating chemotherapy-induced hair loss A method for inhibiting hair loss and/or promoting hair growth in chemotherapy and/or radiation therapy patients wherein the (R)-enantiomer of 4-[[(cyanoimino)-[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile is administered prior to, simultan... | 10/01/2002 |
| 6436914 | 2-hydroxy-3--(4-hydroxy-3-sulfonamidophenyl)--propylamines useful as beta 3 adrenergic agonists Compounds are provided having the formula ##STR1## including pharmaceutically acceptable salts thereof, wherein R1 is lower alkyl, aryl or arylalkyl; A is hydrogen or ##STR2## B is hydrogen, alkyl, alkenyl, or ##STR3## but when A is hydrogen, B... | 08/20/2002 |
| 6395767 | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula ##STR1## where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R1, R2, R3 and... | 05/28/2002 |
| 6369103 | Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor A method is provided for preventing or reducing the risk of onset of a cardiovascular event by administering an HMG CoA reductase inhibitor such as pravastatin, to a patient which has one or more risk factors for a coronary and/or cerebrovascular event su... | 04/09/2002 |
| 6344450 | Lactam compounds and their use as inhibitors of serine proteases and method Lactam inhibitors are provided which have the structure ##STR1## X is ##STR2## wherein Y is O or S and R4 is ##STR3## R7 O-- or R8 and R1, R2, R3, R5, R6, R7 | 02/05/2002 |
| 6297233 | Lactam inhibitors of FXa and method Caprolactam inhibitors are provided which have the structure ##STR1## including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrugs thereof, wherein n is 1 to 5; and and Y R1, R2, R3, R5 | 10/02/2001 |
| 6281228 | Heterocyclic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof, or prodrug ester... | 08/28/2001 |
| 6262122 | Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile The (R)-enantiomer of 4-[[(cyanoimino)-[(1,2,2-trimethylpropyl)amino]methyl]amino]-benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness.... | 07/17/2001 |
| 6150356 | Potassium channel inhibitors and method Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds... | 11/21/2000 |
| 6127370 | Method for treating alzheimer's disease A method is provided for treating occlusive vascular disease or Alzheimer's disease, wherein the patient has at least moderately elevated blood levels of homocysteine and at least moderately reduced blood levels of folate and vitamin B12, where... | 10/03/2000 |
