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| Number | Title | Issue Date |
| 7659281 | HMG-CoA reductase inhibitors Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperl... | 02/09/2010 |
| 7655688 | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 02/02/2010 |
| 7629342 | Azabicyclic heterocycles as cannabinoid receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 12/08/2009 |
| 7625923 | Bicyclic modulators of androgen receptor function The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for examp... | 12/01/2009 |
| 7598262 | Method for treating diabetes A method is provided for first line treatment of type 2 diabetes employing a combination of metformin and glyburide. A method for treating diabetes in drug naive human patients is also provided employing the above formulation to reduce insulin resistance and/or post... | 10/06/2009 |
| 7589193 | C-aryl glucoside SGLT2 inhibitors and method A compound of the formula I A method is also provided for treating diabetes and related diseases employing the above compound alone or in combination with another therapeutic agent. ... | 09/15/2009 |
| 7589088 | Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods Compounds are provided having the formula (I) wherein R, B, X and Y are as defined herein. ... | 09/15/2009 |
| 7579479 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and ... | 08/25/2009 |
| 7553836 | Melanin concentrating hormone receptor-1 antagonists The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1a, R1b | 06/30/2009 |
| 7550445 | Aripiprazole complex formulation and method An aripiprazole formulation is provided which includes the antipsychotic agent aripiprazole in the form of an inclusion complex in a β-cyclodextrin, preferably, sulfobutyl ether β-cyclodextrin (SBECD), which in the form of an injectable produces reversible general... | 06/23/2009 |
| 7521557 | Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods Compounds are provided having the formula (I) wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases. ... | 04/21/2009 |
| 7507838 | Process for the preparation of Z-5-carboxymethylene-1,3-dioxolan-4-ones A process for preparing Z-5-carboxymethylene-1,3-dioxolan-4-ones is provided which includes the steps of reacting a bis-ketal or bis-acetal of tartaric acid with a potassium containing base to form the carboxymethylene-1,3-dioxolan-4-one. A process for preparing HIV... | 03/24/2009 |
| 7507823 | Process of making aripiprazole particles A method of preparation of crystalline aripiprazole monohydrate includes the use of solution enhanced dispersion by supercritical fluid. Specifically, water is introduced to a stream of supercritical fluid which is then allowed to mix with a stream including a mixtu... | 03/24/2009 |
| 7507768 | Antidiabetic formulation and method An antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes, which includes a combination of metformin and glipizide in a manner to control moisture in the formulation so that the glipizide does not hydrolyze, yet the met... | 03/24/2009 |
| 7507757 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH | 03/24/2009 |
| 7507730 | Substituted pyrazolo[1,5-a]pyrimidines as potassium channel activators Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultr... | 03/24/2009 |
| 7488725 | Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods Compounds are provided having the formula: wherein R1, R2, R2′, R3, R3′, R4, R4′, R5, X, Y and Z are as defined herein. ... | 02/10/2009 |
| 7470810 | Alkyl and aryl-thiotrifluoroacetates and process Novel C3-C19 alkyl- and aryl-thiotrifluoroacetates are provided which have the structure wherein Q is C9-C19 alkyl or aryl, and are useful protecting agents for the amino or hydro... | 12/30/2008 |
| 7462616 | Pyrrolo-triazine aniline compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R | 12/09/2008 |
| 7459460 | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators Trisubstituted heteroaromatic compounds having the structure are provided, wherein X is C or N; A and B are each independently CH or N, with the proviso that A and B canno... | 12/02/2008 |
| 7456188 | C-5 substituted quinazolinone derivatives as selective estrogen receptor beta modulators The present application describes compounds according to Formula I, wherein Q, R1, R2 and X are described herein, that are useful as Estrogen Receptor Beta (ERβ) modulators. Additionally, the present application describes pharmaceutical compos... | 11/25/2008 |
| 7452907 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2, X | 11/18/2008 |
| 7425550 | Lactam glycogen phosphorylase inhibitors and method of use A compound of formula I is provided having the structure wherein W is as defined herein; X is —CHR5O—; Y is a bond; Z is a... | 09/16/2008 |
| 7420059 | HMG-CoA reductase inhibitors and method Compounds are provided having the following structure and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, U, V, W, Y... | 09/02/2008 |
| 7396935 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted pyridyl, ring; R2 | 07/08/2008 |
| 7390810 | Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 | 06/24/2008 |
| 7388098 | Dynamic resolution of isomers and resolved isomers Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution i... | 06/17/2008 |
| 7384958 | Quinoline inhibitors of cGMP phosphodiesterase Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5. ... | 06/10/2008 |
| 7381730 | 3-arylquinazoline derivatives as selective estrogen receptor beta modulators Novel quinazoline derivatives possessing activity as estrogen receptor beta (ERβ) modulators are provided which have the general formula I wherein X is O or S; A and B ar... | 06/03/2008 |
| 7378430 | Quinoline inhibitors of cGMP phosphodiesterase Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5. ... | 05/27/2008 |
| 7371759 | HMG-CoA reductase inhibitors and method Compounds are provided having the following structure which are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treat... | 05/13/2008 |
| 7365208 | Method for preparing irbesartan and intermediates thereof A method for preparing irbesartan and intermediates thereof. Irbesartan has the structure of formula I, ... | 04/29/2008 |
| 7338954 | Compounds useful as motilin agonists and method A method is provided for treating disorders of gastrointestinal motility which include the steps of administering to a patient in need of treatment of a compound having the structure or a pharmaceutically acceptable salt th... | 03/04/2008 |
| 7326705 | Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, al... | 02/05/2008 |
| 7326706 | Pyrazine modulators of cannabinoid receptors The present application describes compounds according to Formula I, wherein A, G1, G2 and R1 are described herein. Additionally, the present application describes pharmaceutical compositions comprising at least one compound according... | 02/05/2008 |
| 7279485 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method Substituted heterocyclic derivatives are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)... | 10/09/2007 |
| 7262195 | Compounds useful as motilin agonists and method Compounds are provided which are useful in treating disorders of gastrointestinal motility and which have the structure or a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomer... | 08/28/2007 |
| 7256208 | Monocyclic -Aryl hydantoin modulators of androgen receptor function The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a... | 08/14/2007 |
| 7241780 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y,... | 07/10/2007 |
| 7223573 | Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process. ... | 05/29/2007 |