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| Number | Title | Issue Date |
| 6787109 | Test element analysis system Analysis system for the analytical investigation of a sample, in particular of a body fluid. It consists of test elements brought into contact, for performing an analysis, with a sample to be investigated, and an evaluation apparatus with a test element support for ... | 09/07/2004 |
| 6783957 | Method for synthesis of polypeptides in cell-free systems The method of polypeptide synthesis in eukaryotic or porkaryotic cell-free systems based on a modified verion of synthesis in the continuous flow or continuous exchange modes when, in addition to input into the reaction mixture of components maintaining the synthesi... | 08/31/2004 |
| D493536 | Glucose meter | 07/27/2004 |
| 6720417 | Method and device for refining nucleic acids A device for isolating nucleic acids which reduces the transfer of contaminants during nucleic acid isolation methods which is composed of two vessels which are linked by a closing element in which a material that binds nucleic acids is placed. The nucleic acid can ... | 04/13/2004 |
| 6716640 | Stabilization and amplification of electrochemiluminescence signals The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods. ... | 04/06/2004 |
| 6682704 | Magazine for storing test elements The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite t... | 01/27/2004 |
| 6670173 | Bioreaction module for biochemical reactions A bioreaction module for biochemical reactions, in particular for cell-free polypeptide biosynthesis, having a housing (1) including a system chamber (12) and a supply chamber (10), wherein the system chamber (12) contains a producing system during the bi... | 12/30/2003 |
| 6653456 | Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino... | 11/25/2003 |
| 6645732 | Antigen-specific IgG detection The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin G class in the presence of immunoglobulins of the M class in body fluids by incubation with at least two different receptors R1 and R | 11/11/2003 |
| 6635420 | Purification of substances from a biological sample The invention concerns a method for the purification of a target substance from a biological sample by immobilizing the target substance on a solid phase by means of a high affinity binding pair and subsequently eluting it by adding a partner of the bindi... | 10/21/2003 |
| 6552199 | Fluorescence dyes and their use as fluorescence markers The subject matter of the invention are new xanthene derivatives of the formula I, ##STR1## wherein R1,R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and X, Y, are as defined herein. The compounds according to the invention provide molecules that are--due... | 04/22/2003 |
| 6537496 | Functional overlay for flexible objects in particular for diagnostic test strips A flat-shaped functional overlay for at least one region of a flat-shaped flexible object which does not form a fold when the sandwich composed of the flexible object and overlay is bent towards the side on which the overlay is located is described. The o... | 03/25/2003 |
| 6534325 | Immunoassay for the detection of amphetamines, methamphetamines and methylenedioxy designer amphetamines The present invention provides an immunoassay method for the highly sensitive detection of amphetamines, methamphetamines, and methylenedioxy designer amphetamines in urine samples. Commercially available reagents for the determination of amphetamines and... | 03/18/2003 |
| 6534017 | Test element storage device The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite t... | 03/18/2003 |
| 6524808 | Enzyme inhibition immunoassay The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypepti... | 02/25/2003 |
| 6489129 | Antigen-specific IgM detection The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in body fluids by incubation with at least two different recepto... | 12/03/2002 |
| 6475764 | Recombinant collagenase type I from clostridium histolyticum and its use for isolating cells and groups of cells A polypeptide with the properties of collagenase class I from Clostridium histolyticum (CHC I) and the amino acid sequence SEQ ID NO:2 which is optionally N-terminally extended by one or several amino acids of the sequence SEQ ID NO:3 is advantageously su... | 11/05/2002 |
| 6455001 | Functional layers of high precision, process for their production and test strips containing these functional layers A skeleton-free functional layer of high precision which contains a wetting agent of formula I, II and/or III R1 --CO--N(R2)--CH2 --COOMe (I) R1 --CO--N(R2)--CH2 --CH2 --SO3 Me... | 09/24/2002 |
| 6432722 | Stabilization and amplification of electrochemiluminescence signals The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.... | 08/13/2002 |
| 6419661 | Device for withdrawing blood for diagnostic applications Device for withdrawing Blood for Diagnostic Purposes. A lancet holder (8) for holding a lancet (7) and a lancet drive (12) having a loadable elastic drive spring (15) are provided within an elongated housing (2). The relaxing motion of the drive spring (1... | 07/16/2002 |
| 6413733 | Stabilized reagent and method for determining creatine kinase A stabilized reagent for the photometric enzymatic determination of creatine kinase (CK) in biological sample material by forming ATP from creatine phosphate and ADP and detecting the ATP formed, containing an organic or inorganic sulphur compound prefera... | 07/02/2002 |
| 6406899 | Highly active alkaline phosphatase The invention concerns a DNA coding a eukaryotic highly active alkaline phosphatase with a specific activity of more than 3000 U/mg. The invention also concerns a process for the production of a DNA according to the invention, a vector containing the DNA ... | 06/18/2002 |
| 6376206 | Specific antibodies to troponin T, their production and use in a reagent for the determination of myocardial necrosis An immunoassay for the determination of myocardial necroses using antibodies to troponin T and a binding partner B for troponin T or for the an antibody, whereby either the antibody or the binding partner B is labelled with a determinable group. The immun... | 04/23/2002 |
| 6368814 | Tricyclic antidepressant derivatives and immunoassay The present invention is directed to novel tricyclic antidepressant drug derivatives synthesized for covalent attachment to proteins or polypeptide antigens for use in the preparation of antibodies or receptors to tricyclic antidepressant drugs and tricyc... | 04/09/2002 |
| 6361955 | Immunological process for PSA determination The invention concerns an immunological process for the determination of prostate-specific antigen (PSA), particularly for the determination of free PSA, the total concentration of PSA and the concentration of PSA-serpin complexes by incubation of the sam... | 03/26/2002 |
| 6333397 | Monoclonal antibodies to troponin T and their production An immunoassay for the determination of myocardial necroses using antibodies to troponin T and a binding partner B for troponin T or for the an antibody, whereby either the antibody or the binding partner B is labelled with a determinable group. The immun... | 12/25/2001 |
| 6331402 | Reduction of interference of immunoassays by substances derived from the framework regions of antibodies The invention concerns an immunological process for the detection of an analyte in a sample, in particular of tumor markers wherein for the reduction of interference substances containing a peptide sequence derived from the framework regions of the variab... | 12/18/2001 |
| 6322993 | Method for the determination of lipase The invention concerns a method and reagent for the determination of lipase in the presence of a colour substrate and at least one N-substituted carboxylic acid amide derivative or a compound of the general formula (I) or (Ia) ##STR1## in which R | 11/27/2001 |
| 6281021 | Use of derivatized reagents in chemiluminescence and electrochemiluminescence detection methods The invention concerns methods for the detection of an analyte in a sample by chemiluminescence or electrochemiluminescence using derivatized test reagents. In addition new reagents and reagent kits for chemiluminescence and electrochemiluminescence detec... | 08/28/2001 |
| 6246785 | Automated, microscope-assisted examination process of tissue or bodily fluid samples Method for the automated, microscope-aided examination of tissue samples or samples of body fluids with the aid of neural networks. In a first method of examination the sample is firstly classified according to its type and subsequently a digitalized imag... | 06/12/2001 |
| 6235503 | Procedure for subtractive hybridization and difference analysis Improved methods for obtaining polynucleotides comprising sequences which differ between two populations of DNA or CDNA are provided. Improvements include reduction in the number of amplification cycles, use of a nuclease digestion step prior to amplifica... | 05/22/2001 |
| 6207000 | Process for the production of analytical devices A process for the production of analytical devices is provided in accordance with the present invention. Analytical devices include analytical test elements with a capillary-active zone for examining liquid samples. In the process a carrier layer is prepa... | 03/27/2001 |
| 6184379 | Rhodamine derivatives and the use thereof The invention concerns rhodamine derivatives of the general formulae ##STR1## in which Ca-Cd each denote a C atom, and Ca and Cb as well as Cc and Cd are either linked together by a single bond or by a double bond; X1 to X16 denote independently of one an... | 02/06/2001 |
| 6176119 | Analytical system for sample liquids The invention concerns a system for the analysis of sample liquids, comprising: a) test elements comprising an edge profile; b) a moisture-impermeable, tightly sealable storage container for at least two test elements comprising a guide element, a spacer betwe... | 01/23/2001 |
| 6153393 | Elimination of interference in diagnostic methods by peptides comprising D-amino acids The invention concerns the use of peptides which are comprised essentially of D-amino acids to eliminate interference in diagnostic methods, a method for eliminating interference in diagnostic methods by peptides which are comprised essentially of D-amino... | 11/28/2000 |
| 6110696 | Electrochemical enzyme assay A diagnostic kit, method, and apparatus for electrochemically determining the presence or concentration of an analyte in a sample. A mixture is formed which includes the sample, an enzyme acceptor polypeptide, an enzyme donor polypeptide, and a labeled su... | 08/29/2000 |
| 6107052 | Enzymatic measurement of mycophenolic acid The present invention provides a method for the enzymatic measurement of mycophenolic acid and other IMPDH inhibitors in biological samples. The present invention also provides assay reagents and packaged kits useful for performing enzymatic measurement of myc... | 08/22/2000 |
| 6066505 | Fluorescence polarization immunoassay In a fluorescence polarization assay for determining the amount of a target analyte in a test sample, wherein the amount of analyte is related to the amount of fluorescence emitted from the analyte-containing reagent medium, the improvement comprising con... | 05/23/2000 |
| 6004824 | Propoxyphene derivatives for immunoassay reagents The present invention provides hapten derivatives that are useful for the preparation of antigenic, antibody and label reagents having superior performance characteristics for use in immunoassays for the detection of d-propoxyphene and d-nor-propoxyphene.... | 12/21/1999 |
| 5997817 | Electrochemical biosensor test strip An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes... | 12/07/1999 |
