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| Number | Title | Issue Date |
| 8178128 | Nanoparticles containing polymeric nucleic acid homologs A nanoparticle capable of delivery of an encapsulated molecule into a living cell. The nanoparticle includes an encapsulation media and an isolated nucleic acid homolog sequence. The encapsulation media is primarily polymeric. The nanoparticles release the encapsula... | 05/15/2012 |
| 8153399 | Methods and compositions for inactivating glutamine synthetase gene expression Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as... | 04/10/2012 |
| 8137948 | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography techniques and provide for commercially viable levels of recombinant AAV virions. ... | 03/20/2012 |
| 8124098 | Polypeptides from non-typeable Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine... | 02/28/2012 |
| 8110379 | Targeted integration into the PPP1R12C locus Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest. ... | 02/07/2012 |
| 8101406 | Protective anti-glucan antibodies with preference for β-1,3-glucans Anti-β-1,3-glucan antibodies have been found to be protective against systemic fungal infection with Candida albicans. The present invention provides monoclonal antibodies that bind to β-1,3-glucan, hybridoma cell lines producing the antibodies, composition... | 01/24/2012 |
| 8071370 | Targeted modification of chromatin structure Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, tha... | 12/06/2011 |
| 8062662 | Liposomes containing an entrapped compound in supersaturated solution A liposome composition having a compound entrapped in a supersaturated solution and method for preparing such a composition are described. ... | 11/22/2011 |
| 8034598 | Engineered cleavage half-domains Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion p... | 10/11/2011 |
| 8012946 | Anti-angiogenic methods and compositions Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies. ... | 09/06/2011 |
| 8012465 | Methods for treating renal cell carcinoma Methods for treating renal cell carcinoma using low doses of IL-2 are disclosed. In particular, the invention relates to methods of treating metastatic renal cell carcinoma in patients who are renally impaired and/or intolerant of high dose IL-2 therapy. The therape... | 09/06/2011 |
| 8008060 | Method for growing on a substrate Two different strains of Cordyceps sinensis are placed at two different locations in a medium containing purified rattle snake venom and the two strains are allowed to grow until they meet in a boundary zone where a hybrid strain is formed due to exchange of ... | 08/30/2011 |
| 8007780 | AAV vectors for gene delivery to the lung Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which display tropism for lung tissue. ... | 08/30/2011 |
| 7985887 | Regulation of endogenous gene expression in cells using zinc finger proteins The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins. ... | 07/26/2011 |
| 7985417 | Method of lipid structure preparation A method of inserting a lipid-linked moiety into a lipid assembly, such as a planar lipid monolayer or bilayer, a spherical lipid vesicle, a micelle, or an emulsion envelope monolayer is described. In the method, the lipid assembly and the lipid-linked moiety are co... | 07/26/2011 |
| 7951925 | Methods and compositions for gene inactivation Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ... | 05/31/2011 |
| 7947873 | Compositions and methods for regulation of plant gamma-tocopherol methyltransferase Disclosed herein are zinc finger proteins that bind to target sites in a plant gamma-tocopherol methyl transferase (GMT) gene; compositions comprising these GMT-targeted zinc finger proteins and methods of making and using such zinc finger proteins. Also disclosed a... | 05/24/2011 |
| 7947469 | Modulation of HIV infection Disclosed herein are methods and compositions for modulating HIV infection by regulating expression of one or more receptors. ... | 05/24/2011 |
| 7947309 | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same. ... | 05/24/2011 |
| 7943553 | Randomized libraries of zinc finger proteins The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes. ... | 05/17/2011 |
| 7534613 | Methods of treating parkinson's disease using viral vectors Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease. ... | 05/19/2009 |
| 7521241 | Regulated gene expression in plants A method is provided of regulating transcription in a plant cell from a DNA sequence comprising a target DNA operably linked to a coding sequence, which method comprises introducing an engineered zinc finger polypeptide in said plant cell which polypeptide binds to ... | 04/21/2009 |
| 7507411 | Attenuated influenza NS1 variants Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides, polynucleotides encoding NS1 variant polypeptides, a reverse genetics syst... | 03/24/2009 |
| 7491531 | Randomized libraries of zinc finger proteins The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes. ... | 02/17/2009 |
| 7485458 | Accessory functions for use in recombinant AAV virion production Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producin... | 02/03/2009 |
| 7459143 | Carrier molecules The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particula... | 12/02/2008 |
| 7449566 | Polynucleotide encoding novel HCV non-structural polypeptide Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these... | 11/11/2008 |
| 7449615 | Non-invasive evaluation of physiological response in a transgenic mouse The present invention relates to panels of reporter expression cassettes and the generation of transgenic non-human animals, wherein said reporter expression cassettes have selected control elements operable linked to reporter genes. The invention includes methods o... | 11/11/2008 |
| 7449567 | Isolation and identification of mouse and human transcription control elements associated with cytochrome expression The present invention relates to transcription control elements derived from mouse and human genes associated with cytochrome expression, e.g., Cyp3A11 and CYP3A4, respectively. Isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgen... | 11/11/2008 |
| 7439327 | Stem cell factor-like proteins and uses thereof The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or ... | 10/21/2008 |
| 7429385 | Intracellular production of hepatitis C E1 and E2 truncated polypeptides Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts. ... | 09/30/2008 |
| 7427396 | AAV vectors for gene delivery to the lung Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which display tropism for lung tissue. ... | 09/23/2008 |
| 7411052 | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containi... | 08/12/2008 |
| 7407776 | Engineered zinc finger proteins for regulation of gene expression Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human-sized genome. ... | 08/05/2008 |
| 7393318 | Methods and compositions for interaction trap assays The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antago... | 07/01/2008 |
| 7385060 | Method for producing salts of tolperisone The invention relates to a method for producing an addition salt of 2,4′-dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of formula (I). According to the invention, 4-methylpropiophenone is reacted with piperidine hydroch... | 06/10/2008 |
| 7371386 | Conserved motif of hepatitis C virus E2/NS1 region The hypervariable region (E2HV) of the putative hepatitis C virus (HCV) glycoprotein E2/NS1, between about amino acid 384 to about amino acid 414, is a rapidly evolving region of HCV, and is likely to be under positive immune selection. A newly discovered motif with... | 05/13/2008 |
| 7361635 | Simultaneous modulation of multiple genes Disclosed herein are compositions and methods that regulate expression of two or more endogenous genes. ... | 04/22/2008 |
| 7358085 | Anti-angiogenic methods and compositions Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies. ... | 04/15/2008 |
| 7335639 | IGF-1 composition and its use A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I concentration of at least about 250 mg/ml, a density of about 1.0 g/ml to... | 02/26/2008 |
