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Attorney: Roberts, Jr.; John S.


Number of patents: 228
Last date: May 15, 1990

1            
NumberTitleIssue Date
4925931N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof
N-Homocysteine thiolactonyl retinamido cobalamin is useful for decreasing the induction of chemically-induced tumors in animals. It is also useful for inhibiting weight gain....
05/15/1990
4907576Orthopaedic device using non-stretch material and method for its manufacture
An orthopaedic belt apparatus applicable to any one of several parts of the body consisting of an elastomeric section sized to encompass lumbar muscle groups of the body wearing the orthopaedic belt and having distal ends thereof, a pair of non-stretch se...
03/13/1990
4842716Ethylene furnace antifoulants
An improved method for reducing fouling and corrosion of ethylene cracking furnaces petroleum feedstocks, the improvement comprising treating the petroleum feed stock with at least 10 ppm of a combination of a phosphorous antifoulant compound and a filmin...
06/27/1989
4813433Syringe for withdrawing blood
A syringe for withdrawing fluids which consists of novel new one-handed operated syringe. Said one-handed or therapeutic syringe is described as a therapeutic syringe comprising a double compartmented housing, a piston disposed in one of said compartments...
03/21/1989
4764459Enzyme-linked immunosorbent assay (ELISA) for determining anti-bodies against herpes simplex virus (HSV) types 1 and 2 in human sera
A method and test kit for the serological diagnosis of human infection by herpes sipmlex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) using immunoaffinity purified virus-coded glycoproteins as target antigens. A preferred embodiment of the...
08/16/1988
4762846Metaphit and related compounds as acylating agents for the (3H)phencyclidine receptors
A derivative of phencyclidine (1) bearing an isothiocyanate moiety on the meta position of the aromatic ring (3; Metaphit as methanesulfonate and HCl salt) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [
08/09/1988
4734203Copper chelants/dispersants and their applications for boiler internal treatment
This invention discloses a method of improving the constitution of boiler water by adding thereto an effective amount of a copper transport agent which is either rubeanic acid or a low molecular weight polymer of polypiperazine methyl-para-hydroxysulfonic...
03/29/1988
4729957Process for manufacture of L-asparaginase from erwinia chrysanthemi
A process for the recovery and purification of L-asparaginase from Erwinia chrysanthemi is disclosed. The process involves the preparation of cellular acetone powder extract followed by either an ion exchange and affinity chromatography purification steps...
03/08/1988
4727064Pharmaceutical preparations containing cyclodextrin derivatives
The invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This ...
02/23/1988
4727146Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers ca...
02/23/1988
4722895Synthetic peptides for the production of specific keratin protein antibodies
A process is disclosed for the construction of synthetic peptides corresponding to amino acid sequences of 55-, 59-, 60-, 67-kilodalton keratin proteins. These synthetic peptides make possible the development of monospecific antisera for individual kerati...
02/02/1988
4722888Cell line producing human monoclonal antibody which binds to HTLV-I producing cells
The present invention is an immortalized B-cell line which produces a human monoclonal antibody IgG-Kk which specifically binds to the envelope antigen of human T-cell leukemia virus Type 1 (HTLV-I). This monoclonal antibody is useful as a diagnostic reag...
02/02/1988
4704357Immortalized T-lymphocyte cell line for testing HTLV-III inactivation
This invention is an immortalized T-cell clone, designated ATH8, which is highly sensitive to the cytopathic effect of HTLV-III. The ATH8 T-cell clone is used in mass screening systems to rapidly and easily determine the in vitro capacity of new drugs or ...
11/03/1987
4697066Electric hair curling waved with improved heating element arrangement
An electric heating element for a hair-curling wand having a barrel attached at one end to a handle is inserted into a portion of the barrel and consists of a loop cut out of thin flexible nickel foil having free ends forming terminals for connection to a...
09/29/1987
4696932Biologically-active xanthine derivatives
Certain functionalized cogeners of 1,3-dialkylxanthine exhibit high potency and selectivity as antagonists for A1 - and A2 -adenosine receptors and are suitable for attachment to probes, drug carriers, or solid supports. These deriva...
09/29/1987
4694142Electric air heater
An electric forced-convection air heater consisting of an axial fan and a cage-shaped resistance heating element mounted up-stream of the fan impeller, which serves to heat the air passing there through and to guide the air stream smoothly to the impeller...
09/15/1987
4692463Antiinflammatory 2,3-didemethylcolchicine and additional derivatives
The present invention describes the finding of potent antiinflammatory properties in 2,3-didemethylcolchicine and its analogs....
09/08/1987
4690224Agricultural implement for disposal of crop residue
An agricultural implement for clearing a field of crop residue after harvest is attached to the linkage of a tractor and serves to cut and shred stalks of plants planted in two parallel rows. It comprises two sheave-shaped rollers on a common axle serving...
09/01/1987
4668668Compositions inhibiting murine MXT ductal carcinoma
A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms and Y is amino, inhibits the growth of murine ductal carcinoma (MXT mammary tumors). A compound wherein Z is OH and Y is nitro, administered orally, inhibits the growth of MXT...
05/26/1987
4661683Hair curling set
A hair curler set for heating hair curling rollers includes a case accommodating a plurality of cylindrical hair curler rollers arranged in horizontal or slightly inclined parallel alignment and positioned in a row to one or both sides of an elongated hea...
04/28/1987
4661445Competitive ELISA for the detection of HTLV-III antibodies
A competitive enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies is disclosed. This ELISA technique is more sensitive, more specific, and more accurate than known ELISA techniques. The competitive ELISA of this invention is particul...
04/28/1987
4658047Method of preparing 1,2-diaminocyclohexane tetrachloro platinum (IV) isomers
The present invention is a method of preparing tetrachlorodiamine cyclohexane platinum (IV) by reacting a diamine selected from the group consisting of 1,2-diaminocyclohexane and operable isomers thereof in the form of a dihydrohalide with alkali metal or...
04/14/1987
4652599Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS using permissive cells
A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carrie...
03/24/1987
4650909Polyethylene glycol (PEG) reagent
A process for production of improved polyethylene glycol (PEG) is disclosed. This process overcomes the toxicity that results from using the known (and impure) PEG-fusion reagent by incorporation of a purification method that removes the toxic elements al...
03/17/1987
4647773Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carrie...
03/03/1987
4636496Compositions inhibiting murine MXT ductal carcinoma
A compound of the formula ##STR1## wherein Z is hydrogen and Y is nitro, inhibits the growth of murine ductal carcinoma (MXT mammary tumors)....
01/13/1987
4636469Isolation of hepatitis A virus strain HM-175
Human hepatitis A virus (HAV), taken directly from human clinical specimens, can be isolated and serially passaged in primary African green monkey kidney (AGMK) cell cultures. This strain induced antibody to HAV in inoculated chimpanzees and is useful for...
01/13/1987
4632909Monoclonal antibodies which block infectivity of malarial parasites to mosquitoes
Monoclonal antibodies have been developed that bind with one or more proteins located on the surface of gametes or zygotes of malaria parasites. These antibodies are specific for antigens on mosquito midgut stages of malaria parasite and sterilize the par...
12/30/1986
4622957Therapeutic corset
An improved therapeutic corset which is peculiarly adapted for the sacrum, lumbar and thoracic region of the body comprises an elongated support surface formed from material that is bendable when subjected to forces encountered thereby. Disposed on the su...
11/18/1986
4620978Hepatitis A virus purified and triply cloned
Human hepatitis A virus (HAV) can be purified by a process in which master seed lots of HM-175 strain of hepatitis A virus are prepared from triply cloned virus by terminal dilution at passage level about 20 or preferably at least 20-30. The clones tested...
11/04/1986
4618685N-homocysteine thiolactonyl retinamide and use thereof as an antineoplastic agent
This invention is concerned with a new compound, useful to reduce tumors in laboratory animals, having the following structural formula: ##STR1## The compound is prepared by reacting the free base of homocysteine thiolactone with all trans retinoic a...
10/21/1986
4617556Photosensitive sound generator
A simplified and efficient sound generating device consisting of a self-contained audible signaling device and a means of affording said device protection against moisture and cold temperatures, comprised of a photoelectric cell, a source of energy, a sou...
10/14/1986
4615886Utilizing a halohydrocarbon containing dissolved water to inactivate a lipid virus
A method of inactivating a lipid virus contained in a dry protein carrier by contacting said virus-containing protein carrier for an abbreviated period of time at from 4°-40° C. with a composition including a halohydrocarbon treating agent and water dis...
10/07/1986
4614049Smocking frame
A hand-held smocking apparatus consisting of a crossbar and at least two fabric covered dowels rotatably and perpendicularly attached to said crossbar is suitable for performing needlework on pre-pleated material without tangling, snagging, or crushing th...
09/30/1986
4614379Apparatus for roughening road surfaces
The invention relates to an apparatus for roughening road surfaces, which consists of a roller which is mounted on a chassis so as to be vertically adjustable, is disposed transversely to the direction of travel, is driven by a motor and is equipped with ...
09/30/1986
4612758Cutting finger for finger-bar cutters
The invention relates to a cutting finger for finger-bar cutters of harvesting machines with a top finger and a bottom finger stamped out from flat material and connected to one another in front of the blade gap, in which cutting finger the top finger and...
09/23/1986
4613668Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
There is disclosed herewith a method of producing morphinan compounds by total synthesis which incorporates utilization of N-cycloalkylcarbonyl compounds, which show certain advantages over the prior art which has been previously expressed in U.S. Pat. No...
09/23/1986
4612315Biologically-active 1,3-dipropyl-8-phenylxanthine derivatives
Certain functionalized congeners of 1,3-dialkylxanthine exhibit high potency and selectivity as antagonists for A1 - and A2 -adenosine receptors and are suitable for attachment to probes, drug carriers, or solid supports. These deriv...
09/16/1986
4612282Monoclonal antibodies reactive with human breast cancer
Monoclonal antibodies demonstrating a reactivity with human breast cancer are produced. The hybridoma cultures secreting immunoglobins are produced by hydridoma technology. Splenic lymphocytes of mice, immunized with membrane-enriched fractions of metasta...
09/16/1986
4608339Protoplast fusion method for high-frequency DNA transfection in human cells
A modified protoplast fusion method and cell line is disclosed that stably transfects human cells with pSV2-derived plasmids at frequencies greater than 10-3. This procedure makes it possible to test the biological effect of individual genes (i...
08/26/1986
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