Quotables
"For a list of all the ways technology has failed to improve the quality of life, please press three."
Alice Kahn
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 5059609 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related di... | 10/22/1991 |
| 5036099 | Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide having advantageous properties for formulation as an analgesic or antiinflammatory agent.... | 07/30/1991 |
| 5036104 | Cycloalkyl-substituted glutaramide diuretic agents 2-Acylaminoalkyl-3-[1-(carboxycycloalkylcarbamoyl)cycloalkyl]propanoic acid derivatives (which may also be viewed as glutaramide derivatives) are useful in the treatment of hypertension, heart failure and renal insufficiency, based upon their inhibition o... | 07/30/1991 |
| 5036155 | Process for isopropyl 3S-amino-2R-hydroxy-alkanoates Process and intermediates for isopropyl 3S-amino-4-cyclohexyl-2R-hydroxybutyrate and 3S-amino-2R-hydroxy-5-methylhexanoate from R-malic acid. These products are of known utility in the synthesis of certain renin inhibitors.... | 07/30/1991 |
| 5023085 | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals Transdermal flux enhancers such as oleic acid and 1-dodecylazacycloheptan-2-one are used in combination with iontophoresis in the topical administration of pharmaceutical agents.... | 06/11/1991 |
| 5013729 | Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carbox ylic acids Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(1S-oxo-3R-thiolanylthio)-2-penem-3-carboxylic acid and 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio )-2-penem-3-carboxylic acid, and pharmaceutically-acceptable salts and in vivo hydrolyzable esters... | 05/07/1991 |
| 5013839 | Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) heptanes 1S,4S and 1R,4R-2-alkyl-2,5-diazabicyclo[2.2.1]-heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.... | 05/07/1991 |
| 5010185 | Processes for tigogenin beta-cellobioside Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials.... | 04/23/1991 |
| 4997949 | Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl) thiazole dihydrochloride trihydrate Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride trihydrate having advantageous properties.... | 03/05/1991 |
| 4997981 | Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl) thiazole and analogs An amine substituion process for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole, for precursor N-(pentylamidino)thiourea, and for analogs thereof of said compounds.... | 03/05/1991 |
| 4994457 | Antiinflammatory compositions and methods An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as piroxicam, or a pharmaceutically acceptable salt thereof, with 5'-guanylic acid or N-acetyl-L-methio... | 02/19/1991 |
| 4992562 | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these c... | 02/12/1991 |
| 4992543 | Penem derivatives An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butylsilyloxy)ethyl)-2-azet idon-1 yl]acetic acid ester.... | 02/12/1991 |
| 4992369 | Fermentation process for glycopeptide antibiotic A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in co... | 02/12/1991 |
| 4987231 | Optical resolution method for 3R-(3-carboxybenzyl)-6-(5-fluoro-2-benzothiazolyl)methoxy-4R-chromanol Preparative method for 3R-(3-carboxybenzyl)-6-(5-fluoro-2-benzothiazolyl)methoxy-4R-chromanol via its salt with quinine.... | 01/22/1991 |
| 4977178 | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neurol... | 12/11/1990 |
| 4968707 | Oxazolidin-2-one derivatives as hypoglycemic agents Certain 4-[2-(5-(optionally-substituted-aryl- and heteroaryl)oxazolidin-2-on-3-yl)alkyl]benzoic acids and ester, glycinamide, oxazole and thiazolidinedione derivatives thereof are useful as hypoglycemic agents.... | 11/06/1990 |
| 4965372 | Process and intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates Process and intermediates for isopropyl 3S-amino-4-cyclohexyl-2R-hydroxybutyrate and 3S-amino-2R-hydroxy-5-methylhexanoate from R-malic acid. These products are of known utility in the synthesis of certain renin inhibitors.... | 10/23/1990 |
| 4960792 | Cycloalkyl-substituted glutaramide diuretic agents 2-Acylaminoalkyl-3-[1-(carboxycycloalkylcarbamoyl)cycloalkyl]propanoic acid derivatives (which may also be viewed as glutaramide derivatives) are useful in the treatment of hypertension, heart failure and renal insufficiency, based upon their inhibition o... | 10/02/1990 |
| 4959365 | Topical compositions of lipophilic pharmaceuticals agents Improved pharmaceutical compositions for the topical administration of a lipophilic, pharmaceutical agent to a human or lower animal subject comprising a safe and effective amount of a pharmaceutical agent, an aqueous solvent system comprising from about ... | 09/25/1990 |
| 4954647 | Process for optically active 3-(methane-sulfonyloxy) thiolane and analogs Intermediates and a stepwise process for the conversion of D-methionine or certain of its derivatives to optically active compounds of the formula ##STR1## wherein R is (C1 -C3)alkyl, phenyl or tolyl. The latter compounds are in... | 09/04/1990 |
| 4954482 | New glycopeptide antibiotic A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in co... | 09/04/1990 |
| 4948913 | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these c... | 08/14/1990 |
| 4940823 | Process for optically active 3-thiolanyl sulfonate esters Intermediates and a stepwise process for the conversion of an alkyl 4-chloro-3R-hydroxybutyrate to optically active compounds of the formula ##STR1## wherein R is (C1 -C3) alkyl, phenyl or tolyl. The latter compounds are in turn... | 07/10/1990 |
| 4937184 | N-demethylefrotomycin N-demethylefrotomycin, a valuable new antibiotic substance, is produced by the microbial conversion of mocimycin using a novel, efrotomycin-producing, microbial species ATCC 53758.... | 06/26/1990 |
| 4933475 | Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor Compounds having the formula ##STR1## R1 is hydrogen, benzyl or alkanoyl, X is C2-4 alkylene; and Z-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidia... | 06/12/1990 |
| 4921994 | Pharmacologically active 2-hydroxy-4-(substituted) phenyl cycloalkanes and derivatives thereof Compounds having the formula ##STR1## R1 is hydrogen, benzyl or an ester moiety; Y is --CH(R2 ")CH(R2)-- or --CH(R3)CH2 --; R2 " is hydrogen or methyl; R2 is OH or X-substituted ... | 05/01/1990 |
| 4921972 | Process for optically active 3-thiolanyl sulfonate esters Intermediates and a stepwise process for the conversion of an alkyl 4-chloro-3R-hydroxybutyrate to optically active compounds of the formula ##STR1## wherein R is (C1 -C3)alkyl, phenyl or tolyl. The latter compounds are in turn ... | 05/01/1990 |
| 4920224 | Quinazolin-4(3H)-one derivatives as anticoccidial agents Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazolin-4(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates the... | 04/24/1990 |
| 4920050 | Acidic polycyclic ether antibiotic An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 53862. This novel antibiotic is useful as an anticoccidial in chickens, in the preventi... | 04/24/1990 |
| 4920215 | Antibiotic produced by fermentation The antibiotic of the formula: ##STR1## wherein R is ##STR2## The antibiotic is useful for the treatment of swine dysentery and for promoting growth and/or increasing the efficiency of food utilization in poultry, swine and ruminants.... | 04/24/1990 |
| 4916226 | Optical resolution method for 3S-(3-pyridylmethyl)-6-(2-quinolyl)-methoxy-4S-chromanol Preparative method for 3S-(3-pyridylmethyl)-6-(2-quinolyl)methoxy-4S-chromanol via its salt with natural tartaric acid.... | 04/10/1990 |
| 4895940 | Process for the preparation of penems An efficient, multistep process for the synthesis of 6-(1-hydroxyethyl) 2-thio-substituted penem antibiotics from 2-[4R-(triphenylmethy lthio)-3S-(1S-(dimethyl-t-butylsilyloxy)ethyl)-2-azetidon-1-yl]acetic acid esters.... | 01/23/1990 |
| 4885370 | Synthetic method for indol-2(3H)-ones A two-step process for the synthesis of certain indol-2(3H)-ones from indoles, and the 3,3-dibromoindol-2-(3H)-ones which are intermediates in that process.... | 12/05/1989 |
| 4879391 | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neurol... | 11/07/1989 |
| 4874757 | Antinflammatory compositions and methods An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pir... | 10/17/1989 |
| 4874877 | Process for optically active 3-(methane-sulfonyloxy)thiolane and analogs Intermediates and a stepwise process for the conversion of D-methionine or certain of its derivatives to optically active compounds of the formula ##STR1## wherein R is (C1 -C3) alkyl, phenyl or tolyl. The latter compounds are i... | 10/17/1989 |
