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| Number | Title | Issue Date |
| 6689881 | Method for preparing substituted [1,4]diazepino[6,7,1-hi]indol-4-ones Method for the preparation of enantiomerically pure diazepino-indolone of formula ##STR1## which comprises the intramolecular cyclization of a product of formula ##STR2## where A, B, X1, X2, Z, Z1, Z2 and R are ... | 02/10/2004 |
| 6602875 | Sorbitol dehydrogenase inhibitors This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, ##STR1## wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to pharmaceutical compositions... | 08/05/2003 |
| 6579879 | Pyridazinone aldose reductase inhibitors The present invention relates to novel pyridazinone compounds, pharmaceutical compositions comprising those compounds and to methods of using such compounds and compositions to inhibit aldose reductase, lower sorbitol levels and, thus, lower fructose leve... | 06/17/2003 |
| 6570013 | Salts of zopolrestat This invention relates to [4-oxo-(5-trifluoromethyl-benzothiazol-2-ylmethyl)-3,4-dihydro-phthalazin- 1-yl]-acetic acid ethanolamine salt, pharmaceutical compositions thereof and methods of treating diabetic complications in mammals comprising administ... | 05/27/2003 |
| 6559168 | Thiazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the for... | 05/06/2003 |
| 6555538 | 5-arylsulfonyl-imidazo[1',2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds This application is directed to a compound of Formula I ##STR1## wherein a, X, R1, R2, R3 and R4 are as defined herein, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, infla... | 04/29/2003 |
| 6555540 | Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug and a selective COX-2 inhibitor, a prodrug ther... | 04/29/2003 |
| 6544983 | Diazepinoindoles for the treatment of chronic obstructive pulmonary disease The present invention relates to the use of diazepinoindoles of the formula (I): ##STR1## in which A is aryl or nitrogen-containing heteroaryl, and B is a hydroxyl or amino radical, for the treatment of chronic obstructive pulmonary disease.... | 04/08/2003 |
| 6544998 | Combination of gaba agonists and sorbitol dehydrogenase inhibitors This invention relates to pharmaceutical compositions comprising combinations of a GABA agonist, a prodrug thereof or a pharmaceutically acceptable salt of said GABA agonist or said prodrug and a SDI, a prodrug thereof or a pharmaceutically acceptable sal... | 04/08/2003 |
| 6525032 | Purine derivatives The present invention relates to compounds of the class of purin-2-ylcarboxamides, useful as anti-inflammatory agents, having the formula: ##STR1## and pharmaceutically acceptable salts and solvates thereof; wherein R1 is H, C1 ... | 02/25/2003 |
| 6514975 | Anti-inflammatory piperazinyl-benzyl-tetrazole derivatives and intermediates thereof This invention relates to tetrazoles and their pharmaceutically acceptable salts which are selective agonists for the delta opioid receptor, particularly useful in the treatment of inflammatory diseases such as arthritis, psoriasis, asthma, inflammatory b... | 02/04/2003 |
| 6511981 | Compositions and treatment for diabetic complications This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug and a selective COX-2 inhibitor, a prodrug ther... | 01/28/2003 |
| 6489457 | Human phosphodiesterase IV isozymes This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences. This invention also relates to an assay method for detecting the presence of... | 12/03/2002 |
| 6486182 | Mutual prodrugs of amlodipine and atorvastatin This invention relates to mutual prodrugs of amlodipine and atorvastatin and to pharmaceutical compositions thereof. This invention also relates to methods of treating angina pectoris, atherosclerosis, and hypertension and hyperlipidemia in a mammal using... | 11/26/2002 |
| 6455574 | Therapeutic combination This invention relates to pharmaceutical combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and atorvastatin or a pharmaceutically acceptable salt thereof, kits containing such combinations and methods of using such com... | 09/24/2002 |
| 6414149 | Sorbitol dehydrogenase inhibitors This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, ##STR1## wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to pharmaceutical compositions... | 07/02/2002 |
| 6372781 | Compounds for treating gastroduodenal diseases Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1 -C5) alkyl or CH3 (CH2)n CO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal... | 04/16/2002 |
| 6329408 | Hypoglycemic thiazolidinediones and intermediates Optically pure thiazolidinedione alcohols and ethers, and synthetic intermediates for preparing said alcohols and ethers. These compounds have utility as hypoglycemic and hypocholesterolemic agents.... | 12/11/2001 |
| 6313140 | Method of treatment using certain growth-hormone secret agogues This invention is directed to compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenou... | 11/06/2001 |
| 6306875 | Growth-hormone secretagogues This invention is directed to compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenou... | 10/23/2001 |
| 6284773 | Therapeutic combinations comprising a selective estrogen receptor modulator and prostaglandin E2 This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydr onaphthalene-2-ol or a pharmaceutically acceptable salt thereof and PGE2 or a pharm... | 09/04/2001 |
| 6278000 | Growth-hormone secretagogues This invention is directed to compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenou... | 08/21/2001 |
| 6262092 | Mutual salt of amlodipine and atorvastatin This invention relates to a mutual salt of amlodipine and atorvastatin, pharmaceutical compositions thereof and methods of treating angina pectoris, atherosclerosis and combined hypertension and hyperlipidemia in mammals with such a mutual salt and compos... | 07/17/2001 |
| 6258827 | Combinations for the treatment of parkinsonism containing selective NMDA antagonists This invention relates to a method of treating Parkinson's Disease whereby a mammal suffering from Parkinson's Disease is treated with a combination of a forebrain selective NMDA antagonist and a compound which is capable of increasing the excitatory feed... | 07/10/2001 |
| 6251902 | Dipeptide derivatives as growth hormone secretagogues This invention is directed to compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenou... | 06/26/2001 |
| 6132774 | Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydr onaphthalene-2-ol or a pharmaceutically acceptable salt thereof and parathyroid hor... | 10/17/2000 |
| 6130241 | Insect-repellent formulations The invention provides an insect- or acarid-repellent formulation comprising a compound of formula (I), wherein R represents straight or branched chain C2-10 alkyl, straight or branched chain C2-10 alkenyl, or straight or branched ch... | 10/10/2000 |
| 6124457 | Process and intermediates for a ଲ3 -adrenergic receptor agonist The instant invention relates to intermediates of Formula II, ##STR1## wherein R1, R2 and R3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to proce... | 09/26/2000 |
| 6124314 | Osteoporosis compounds This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 09/26/2000 |
| 6110932 | Growth hormone secretagogues This invention is directed to compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endo... | 08/29/2000 |
| 6107306 | Heterocyclic compounds This invention is directed to compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endo... | 08/22/2000 |
| 6090942 | Process and intermediates for a ଲ3 -adrenergic receptor agonist The instant invention relates to intermediates of Formula II, ##STR1## wherein R1, R2 and R3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to proce... | 07/18/2000 |
| 6074855 | Process for preparing spirolaxine and spirolaxine methyl ether Processes for preparing spirolaxine and spirolaxine methyl ether, the compounds of formulas (I) and (II) respectively, ##STR1## comprising fermenting fungi selected from the group consisting of Sporotrichum pruinosum FD 29585, ATCC 74327; Sporotrichu... | 06/13/2000 |
| 6046213 | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives This invention relates to compounds of formula (I), or pharmaceutically acceptable acid addition salts thereof, wherein: (a) R2 and R5 are taken separately and R1, R2, R3 and R4 are each in... | 04/04/2000 |
| 6037505 | Enantioselective oxazaborolidine catalysts The anantoselective borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by performing the reduction in the precence of catalytic amounts of the new and valuable oxazaborolidine compounds of formulas (I) and (II). The c... | 03/14/2000 |
| 6034107 | 5-Substituted picolinic acid compounds and their production process The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 and R2 are independently H, C2 -C6 acyl or halo-... | 03/07/2000 |
| 6014212 | Method and apparatus for spectrophotometrically analysing characteristics of a tablet A method of and apparatus for spectrophotometrically analyzing a tablet by NIR transmission measurements includes a tablet holder 1 having a recess 5 within which a tablet 20 is located. A probe 40 is applied to the tablet 20 to direct an NIR beam 45 to a... | 01/11/2000 |
| 6005133 | Enantioselective oxazaborolidine catalysts The enantioselective borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by performing the reduction in the presence of catalytic amounts of the new and valuable oxazaborolidine compounds of formulae (I) and (II). The ... | 12/21/1999 |
| 5883080 | Antiparastic auermectin derivatives Antiparasitic avermectin derivatives of formula (I), where the broken line represents an optional bond, R1 and R4 are independently H, OH, halo, oximino, or an organic radical, R2, R6 and R7 are organ... | 03/16/1999 |
| 5861393 | Antithrombotic amidinophenylalanine and amidinopyridylalanine derivatives This invention relates to compounds of formula (I), ##STR1## pharmaceutically acceptable salt thereof, and pharmaceutically acceptable solvates of either entity, wherein X is CH or N; Y is optionally monousaturated C3 -C5 alkyle... | 01/19/1999 |
