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| Number | Title | Issue Date |
| 6586448 | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 07/01/2003 |
| 6537987 | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, anti-Alzheimer's agents or anti-acne agents.... | 03/25/2003 |
| 6492412 | Prevention of loss and restoration of bone mass by certain prostaglandin agonists Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disor... | 12/10/2002 |
| 6489478 | 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 12/03/2002 |
| 6395751 | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 05/28/2002 |
| 6362198 | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 03/26/2002 |
| 6310075 | Annulated 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 10/30/2001 |
| 6297269 | Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors Compounds of the formula I: ##STR1## and their compositions are useful as glycogen phosphorylase inhibitors.... | 10/02/2001 |
| 6288120 | Prevention of loss and restoration of bone mass by certain prostaglandin agonists Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostag... | 09/11/2001 |
| 6277877 | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors Compounds of Formula (I) ##STR1## wherein R6 is carboxy, (C1 -C8)alkoxycarbonyl, benzyloxycarbonyl, C(O)NR8 R9 or C(O)R12 as glycogen phosphorylase inhibitors, pharmaceutical compositions c... | 08/21/2001 |
| 6262046 | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists Compounds of the formula (I): ##STR1## where X1, A, Ar1, X and R are as defined in the specification, and pharmaceutically-acceptable salts thereof, are new, and are useful as tachykinin inhibitors which act at the NK1, NK... | 07/17/2001 |
| 6207664 | Squalene synthetase inhibitor agents This invention relates to certain squalene synthetase inhibitors useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, anti-Alzheimer's agents or anti-acne agents.... | 03/27/2001 |
| 6200978 | Compounds as delta opioid agonists Compounds of the formula (I)--shown below--are described. ##STR1## The compounds are useful in the manufacture of a pharmaceutical composition for preventing or treating inflammatory diseases such as arthritis, psoriasis, asthma, or inflammatory bowel dis... | 03/13/2001 |
| 6197786 | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 03/06/2001 |
| 6194439 | Tricyclic polyhydroxylic tyrosine kinase inhibitors Certain tricyclic polyhydroxylic compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).... | 02/27/2001 |
| 6147090 | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 11/14/2000 |
| 6147089 | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 11/14/2000 |
| 6140342 | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 10/31/2000 |
| 6140343 | 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma l... | 10/31/2000 |
| 6127367 | Method of reducing tissue damage associated with non-cardiac ischemia A method of preventing non-cardiac tissue damage resulting from ischemia, comprising administering to a patient in need of such treatment an effective amount of an aldose reductase inhibitor.... | 10/03/2000 |
| 6124363 | Dofetilide polymorphs The invention relates to the substantially pure dofetilide polymorphs P162, P162a and P143, and to processes for the preparation of, compositions containing and to the uses of, such polymorphs.... | 09/26/2000 |
| 6107329 | Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors Compounds of Formula (1) wherein R6 is carboxy, (C1 -C8)alkoxycarbonyl, benzyloxycarbonyl, C(O)NR8 R9 or C(O)R12 as glucogen phosphorylase inhibitors, pharmaceutical compositions containing... | 08/22/2000 |
| 6083956 | Optically pure androgen mediator This invention relates to an optically pure androgen mediator, pharmaceutical compositions containing the stereoisomer and the use of the stereoisomer to aid in the prevention and restoration of for example, age-related decline in muscle mass and strength... | 07/04/2000 |
| 6080058 | Hood door airfoil An apparatus for directing the flow of air in a laboratory-type hood. A laboratory hood is provided with a closure sash and the lower edge of the closure sash has an airfoil that extends into the laboratory hood work space.... | 06/27/2000 |
| 6077871 | Droloxifene pharmaceutical compositions Compositions of matter comprising droloxifene or a pharmaceutically acceptable salt thereof and a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry inclusion complex or an aqueous solution. The ci... | 06/20/2000 |
| 6001856 | ଲ-adrenergic agonists to reduce a wasting condition The present invention relates to the use of certain ଲ-adrenergic agonists to reduce a wasting condition in a mammal (e.g., human).... | 12/14/1999 |
| 6001822 | Antiparasitic formulations A parenteral formulation for 25-cyclohexyl-avermectin Bl, compound (I), which is effective against both internal and external parasites, is well tolerated by animals on both subcutaneous and intramuscular administration and is compatible with conventional... | 12/14/1999 |
| 6001860 | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) A compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R17, R18 and R1 are as defined below. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransfe... | 12/14/1999 |
| 5968950 | Apo B-secretion/MTP inhibitor hydrochloride salt A hydrochloride salt of an Apo B secretion/MTP inhibitor, methods of making the salt, methods of using the salt and pharmaceutical compositions containing the salt are disclosed.... | 10/19/1999 |
| 5965553 | Squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, Alzheimer's agents or anti-acne agents.... | 10/12/1999 |
| 5952322 | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors A method of preventing non-cardiac tissue damage resulting from ischemia and/or hypoxia, comprising administering to a patient in need of such treatment an effective amount of an glycogen phosphorylase inhibitor.... | 09/14/1999 |
| 5939398 | Hypocholesterolemic agents This invention relates to certain steroidal glycosides useful as hypocholesterolemic agents and antiatherosclerosis agents and certain protected intermediates useful in the preparation of said steroidal glycosides.... | 08/17/1999 |
| 5932581 | Method of reducing tissue damage associated with ischemia A method of preventing tissue damage resulting from ischemia, comprising administering to a patient in need of such treatment an effective amount of a sorbitol dehydrogenase inhibitor.... | 08/03/1999 |
| 5917034 | Antithrombotic n-amidinopiperidine and benzamidine derivatives Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates of either entity, wherein A is optionally monosaturated C1 -C4 alkylene optionaly monounsaturatred with C1 -C | 06/29/1999 |
| 5914092 | Fermentation tank sample valve steam sterilization apparatus An apparatus for maintaining the sterilization of a reactor vessel output. The apparatus comprises a connect means for connecting to and enclosing the reactor vessel output and a steam trap means for maintaining steam pressure. The steam trap means is in ... | 06/22/1999 |
| 5908930 | 5,10-dihydropyrimdo4,5-b!quinolin-4(1H)-one tyrosine kinase inhibitors Certain 5,10-dihydropyrimido4,5-b!quinolin-4(1 H)-one compounds, and their pharmaceutically-acceptable salts, are useful as inhibitors of tyrosine kinase enzymes and for the treatment of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis,... | 06/01/1999 |
| 5905034 | Method for precipitating natural avermectins A process for separating a natural B avermectin from a natural avermectin containing fermentation broth by using an aqueous precipitation. The process comprises extracting natural avermectins from the fermentation broth with a water miscible solvent and a... | 05/18/1999 |
| 5837724 | Method of enhancing cognition Darifenacin, and its pharmaceutically acceptable salts, are useful in the treatment of cognitive impairment. The invention also discloses the use of combinations of darifenacin, or a pharmaceutically acceptable salt thereof, with an acetylcholinesterase i... | 11/17/1998 |
| 5827538 | Osmotic devices having vapor-permeable coatings An osmotic device that, following the imbibement of water vapor, provides for the controlled release of a beneficial agent to an aqueous environment. The device comprises a hydrophilic formulation including a beneficial agent, and if needed, an osmagent, ... | 10/27/1998 |
| 5807834 | Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor Pharmaceutical combination compositions including certain cholesterol absorption inhibitors and cholesterol synthesis inhibitors. The compositions are useful for the treatment of hypercholesterolemia and atherosclerosis.... | 09/15/1998 |
