Richardson; Peter C., Benson; Gregg C., Jones; James T. - US Patent Attorneys and Agents

Attorney: Richardson; Peter C., Benson; Gregg C., Jones; James T.

Number of patents: 56
Last date: June 03, 2003

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Number	Title	Issue Date
6573383	Preparation of anhydrous CETP inhibitor This invention relates to methods for preparing anhydrous CETP inhibitor, (2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-2-ethyl -6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester....	06/03/2003
6537573	Combination dosage form comprising cetirizine and pseudoephedrine A dosage form containing cetirizine as an immediate release component and pseudoephedrine or a pharmaceutically acceptable salt thereof as a controlled release component. A portion of the pseudoephedrine can also be incorporated as an immediate release co...	03/25/2003
6534511	Bicyclic heterocyclic compounds for the treatment of impotence The use of certain 6-arylpyrazolo[3,4-d]pyrimidin-4-ones, 2 arylquinazolin-4-ones, 2-arylpurin-6-ones and 2-arylpyrido[3,2-d]pyrimidin-4-ones, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing either entity, for the...	03/18/2003
6503908	Pharmaceutically active compounds There is provided compounds of formula I, ##STR1## wherein R1, R2, R3 and Het1 have meanings given in the description, which are useful in the curative and prophylactic treatment of medical conditions for which ...	01/07/2003
6469012	Pyrazolopyrimidinones for the treatment of impotence The use of a compound of formula (I) ##STR1## wherein R1 is H; C1 -C3 alkyl; C1 -C3 perfluoroalkyl; or C3 -C5 cycloalkyl; R2 is H; optionally substituted C1...	10/22/2002
6458951	Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction Compounds of the formulae (IA) and (IB): ##STR1## wherein R1 is C1 to C3 alkyl optionally substituted with phenyl, Het or a N-linked heterocyclic group selected from piperidinyl and morpholinyl; wherein said phenyl group i...	10/01/2002
6420557	Crystalline therapeutic agent A polymorph of 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4, 3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine....	07/16/2002
6407114	Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction There is provided compounds of formula IA and of formula IB, ##STR1## wherein R1, R2, R3, R4 and A have meanings given in the description, which are useful in the curative and prophylactic treatment of a medical...	06/18/2002
6399777	Inclusion complexes of aryl-heterocyclic salts The esylate, mesylate, and tartrate salts of ziprasidone exhibit excellent solubilities in cyclodextrins....	06/04/2002
6333330	Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction There is provided compounds of formula IA and of formula IB, ##STR1## wherein R1, R2, R3, R4 and A have meanings given in the description, which are useful in the curative and prophylactic treatment of medical c...	12/25/2001
6300335	4-aminoquinazoline derivative cGMP-PDE inhibitors for the treatment of erectile dysfunction 4-aminoquinazoline derivatives which are selective inhibitors of cGMP PDE are useful in the treatment of erectile dysfunction (impotence) in male animals, including man....	10/09/2001
6251904	Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction Compounds of the formulae (IA) and (IB): ##STR1## wherein R1 is C1 to C3 alkyl optionally substituted with phenyl, Het or a N-linked heterocyclic group selected from piperidinyl and morpholinyl; wherein said phenyl group i...	06/26/2001
6235742	5-substituted pyrazolo[4,3-D]pyrimidin-7-ones Compounds are disclosed which are useful as PDE1 inhibitors. The compounds have the formula: ##STR1##...	05/22/2001
6232304	Inclusion complexes of aryl-heterocyclic salts Compositions of matter comprising a pharmaceutically acceptable salt of an aryl-heterocyclic compound, such as ziprasidone, in a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry inclusion complex...	05/15/2001
6171618	Combination dosage form comprising cetirizine and pseudoephedrine A dosage form containing cetirizine as an immediate release component and pseudoephedrine or a pharmaceutically acceptable salt thereof as a controlled release component. A portion of the pseudoephedrine can also be incorporated as an immediate release co...	01/09/2001
6166025	Pharmaceutical compositions containing eletriptran hemisulphate and caffeine The present invention provides an aqueous pharmaceutical composition comprising 5 to 200 mg/ml of eletriptan hemisulfate and from 0.5 to 2.0% weight/volume of caffeine....	12/26/2000
6153746	Process for making a cyclodextrin Sulfoalkyl ether cyclodextrins are produced by a process of treating an unsubstituted cyclodextrin starting material with an alkyl sultone in the presence of a base. The base is added in a stepwise, pH controlled manner so that substantially the entire in...	11/28/2000
6150366	Ziprasidone formulations Compositions comprising crystalline ziprasidone free base or crystalline ziprasidone hydrochloride particles having a mean particle size less than 85 μm, and a pharmaceutically acceptable carrier, are substantially bioequivalent and can be used to treat ...	11/21/2000
6106864	Pharmaceutical formulations containing darifenacin There is provided a pharmaceutical dosage form adapted for administration to the gastrointestinal tract of a patient, comprising darifenacin, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable adjuvant, diluent or carrier, ch...	08/22/2000
6100270	Bicyclic heterocyclic compounds for the treatment of impotence A method of treating male erectile dysfunction comprising administering to a male human a pyrimidine compound of formula I....	08/08/2000
6080761	Inhibition of smooth muscle cell migration by (R)-amlodipine The R(+) isomer of amlodipine is a potent inhibitor of smooth muscle cell migration despite its lack of calcium channel-blocking activity. It is useful for treating atherosclerosis, re-stenosis after angioplasty and endometriosis....	06/27/2000
6071938	Benzopyrans A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein X, O R, R1, R2, R3, and R4 are defined in the specification; compositions containing such compounds; intermediates ...	06/06/2000
6068859	Controlled-release dosage forms of Azithromycin A controlled-release dosage form of azithromycin having an improved side effect profile; a process for preparing the dosage form; and a method of treating a microbial infection, comprising administering azithromycin in such a controlled-release dosage for...	05/30/2000
6066735	Process for preparing sildenafil A process for the preparation of a compound of formula (I): ##STR1## which comprises cyclization of a compound of formula (II): ##STR2##...	05/23/2000
6046338	Separation of the enantiomers of amlodipine via their diastereomeric tartrates A method for the separation of R-(+)- and S-(-)-isomers of amlodipine (I) from mixtures thereof, which comprises the reaction of the mixture of isomers with either L- or D-tartaric acid in an organic solvent containing sufficient dimethyl sulphoxide (DMSO...	04/04/2000
5977124	ଲ-adrenergic agonists ଲ-adrenergic agonists for the treatment of diseases/conditions such as obesity and diabetes. The compounds have formula (I), wherein R1, R2, R3, R4, R5, R6, R7, W, X, Y and Z ar...	11/02/1999
5955611	Process for preparing sildenafil A process for the preparation of a compound of formula (I): ##STR1## which comprises cyclization of a compound of formula (II): ##STR2##...	09/21/1999
5952326	Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases Compounds of the formula ##STR1## wherein R is an optionally substituted heteroaryl group such as 2-chromanyl, 2-pyridyl or 5-fluoro-2-benzothiazoyl; X is O, S or (CH2)m ; R1 is phenyl or pyridyl, optionally substituted by...	09/14/1999
5922747	Indole derivatives as steroid 5଱-reductase inhibitors A method of treatment of a human to inhibit a steroid 5଱-reductase, particularly a testosterone 5଱-reductase, which comprises treating said human with an effective amount of a compound of the formula (I) ##STR1## or a pharmaceutically acc...	07/13/1999
5919795	Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion Compounds of formula (I), ##STR1## wherin X is CH2, CO, CS or SO2 ; Y is selected from: a direct link, aliphatic hydrocarbylene radicals having up to 20 carbon atoms, which radical may be mono-substituted by hydroxy, (C1	07/06/1999
5912244	Benzopyrans A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein X is O, S or NH; R and R1 are each independently selected from H and C1 -C4 alkyl or taken together represent C2 -C...	06/15/1999
5876752	Use of interfacially-polymerized membranes in delivery devices Devices for controlled release of active substances in the form of tablets, capsules and beads comprised of a porous substructure surrounded by one or more interfacial membranes....	03/02/1999
5763467	Hypoglycemic hydroxyurea derivatives Certain 1-(benzyl or 5-benzofuranylmethyl)-1-hydroxyurea derivatives are useful as hypoglycemic and hypocholesterolemic agents....	06/09/1998
5750707	Separation of the enantiomers of amlodipine via their diastereomeric tartrates A method for the separation of R-(+)- and S-(-)-isomers of amlodipine (I) from mixtures thereof, which comprises the reaction of the mixture of isomers with either L- or D-tartaric acid in an organic solvent containing sufficient dimethyl sulphoxide (DMSO...	05/12/1998
5719283	Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents Compounds of the formula ##STR1## wherein R1 is H, C1 -C3 alkyl, C3 -C5 cycloalkyl or C1 -C3 perfluoroalkyl; R2 is H, C1 -C6 alkyl optionally sub...	02/17/1998
5698550	Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases Compounds of the formula ##STR1## wherein R is an optionally substituted heteroaryl group such as 2-chromanyl, 2-pyridyl or 5-fluoro-2-benzothiazoyl; X is O, S or (CH2)m ; R1 is phenyl or pyridyl, optionally substituted by...	12/16/1997
5696146	Indole derivatives as steroid 5଱-reductase inhibitors Compounds of formula (I) ##STR1## and the pharmaceutically acceptable base salts thereof, wherein R is --CO2 H or tetrazol-5 yl; R1 is C3 -C8 alkyl optionally substituted by fluoro; and R2 is C	12/09/1997
5686587	Intermediate for azithromycin A compound having formula (III). Also, a process of making azithromycin comprising reducing the compound of formula (III) and N-methylating the reduced product....	11/11/1997
5677324	Benzopyranes as potassium channel openers The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein the dashed line represents an optional covalent bond; X is O, NH, S or a direct link; R3 is hydroxy when the dashed line does n...	10/14/1997
5648502	Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid 4-Chloro-2-thiophenecarboxylic acid is made by forming a compound of formula (Ia), disclosed herein, wherein R3 is (C1 -C6) alkyl, phenyl, or benzyl; converting the compound to a compound of formula (IVa), disclosed herein...	07/15/1997

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Attorney: Richardson; Peter C., Benson; Gregg C., Jones; James T.