Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 6268489 | Azithromycin dihydrate Non-hygroscopic, azithromycin (9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin) dihydrate and a process therefor.... | 07/31/2001 |
| 6204286 | Estrogen agonists/antagonists Compounds of the formula: ##STR1## are disclosed useful for treating osteoporosis, obesity, breast cancer, endometriosis, cardiovascular disease and prostatic disease. Substituents A, B, E, D, Z1, G, Y and e have the same meaning as defined in the sp... | 03/20/2001 |
| 6197822 | Neuropeptide antagonists The compound ##STR1## is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.... | 03/06/2001 |
| 6187778 | 4-aminopyrrole (3, 2-D) pyrimidines as neuropeptide Y receptor antagonists This invention provides a means of inhibiting or preventing a disease or condition associated with an excess of neuropeptide Y which comprises administering to a mammal in need of such treatment an effective amount of a compound of the formula: ##STR... | 02/13/2001 |
| 6180647 | Substituted benzolactam compounds as substance P antagonists Compounds of the formula are effective for the treatment of conditions in mammals which require inhibition of the action of substance P.... | 01/30/2001 |
| 6153622 | Estrogen agonists/antagonists Compounds of this formula ##STR1## are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.... | 11/28/2000 |
| 6096893 | Process and intermediates for 3-heteroaryl-4(3H) quinazolines A new pyridine carbaldehyde is useful for the synthesis of compounds which are effective for treating neurodegeneration conditions and CNS trauma.... | 08/01/2000 |
| 6040310 | 4-aminopyrrole (3,2-d) pyrimidines as neuropeptide Y receptor antagonists A method of treating conditions associated with neuropeptide Y which comprises administering a compound of the formula ##STR1## to a mammalian subject in need of such treatment.... | 03/21/2000 |
| 6030792 | Assays for measurement of protein fragments in biological media This invention provides novel antibodies and engineered versions thereof and methodology for monitoring biological media for protein fragments, especially collagen fragments resulting from collagenase cleavage of type II collagen.... | 02/29/2000 |
| 6031114 | Process for pyrrolidinyl hydroxamic acid compounds A method for preparing hydroxamic acid derivatives which are useful as analgesic, antiinflammatory, or neuroprotective agents.... | 02/29/2000 |
| 5998451 | Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related di... | 12/07/1999 |
| 5998623 | Process and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-a mide A process for preparing the compound of formula (1) is disclosed. ##STR1## The starting materials are an N-triazolylmethyl-6-aminoisoquinoline and a 4-biphenyl-2-carboxylic acid derivative.... | 12/07/1999 |
| 5985932 | Inhibition of autoimmune diseases The present invention provides novel methods of inhibition of autoimmune diseases comprising administering to a mammal in need of treatment an effective amount of a compound of formula I ##STR1## wherein R1 and R2 may be the sam... | 11/16/1999 |
| 5981762 | Substituted indole-2-carboxylic acids as glucosyl transferase inhibitors Indole carboxylic acids are useful as UGGTASE inhibitors.... | 11/09/1999 |
| 5977131 | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents Compounds of formula I are useful in treatment of conditions associated with depletion of nicotine receptors in mammals. ##STR1##... | 11/02/1999 |
| 5948809 | (-) cis-6(S)-phenyl-5(R)4-(2-pyrrolidin-1-yl ethoxy) phenyl!-5,6,7,8-tetrahydronaphthalen-2-ol-D-tartrate (-)Cis-6(S)-phenyl-5(R)-4-(2-pyrrolidin-1-yl ethoxy)phenyl!-5,6,7,8-tetrahydro-naphthalen-2-ol D-tartrate, pharmaceutical compositions comprising this compound, and an advantageous process for preparing the compound.... | 09/07/1999 |
| 5914329 | Dimesylate salts of neuropeptide Y ligands The dimesylate salt of cis-1-(3-ethoxyphenyl)-1-(4-phenylpiperazin-1-yl)4-methyl-cyclohexane has superior properties and is useful to treat physiological disorders associated with an excess of neuropeptide Y.... | 06/22/1999 |
| 5902830 | Use of droloxifene for the treatment of cardiovascular disease Use of droloxifene in the treatment of cardiovascular diseases.... | 05/11/1999 |
| 5900415 | Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands This invention encompasses compounds of formula (I) and the pharmaceutically ##STR1## acceptable salts thereof, wherein W,X,Y,A,T,R1 -R4,B,Ar,n and m are described herein and are useful in treating feeding disorders and cer... | 05/04/1999 |
| 5861438 | Combination therapy to prevent bone loss parathyroid hormone and estrogen agonists The present invention provides novel methods of inhibiting bone loss comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1## wherein R1 and R2 may be the same or dif... | 01/19/1999 |
| 5852031 | 2,7-substituted octahydro-1H-pyrido1,2-a!pyrazine derivatives Substituted pydrido1,2-a!pyrazines of general formula I wherein Ar and Ar1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO2, C.dbd.O, CHOH, or --(CR3 R4) and n is 0-2 a... | 12/22/1998 |
| 5852059 | Use of droloxifene for the treatment of protastic disease, endometriosis and obesity This invention provides a method for treating a condition or disease selected from endometriosis, obesity, benign prostatic hypertrophy and prostatic carcinoma in mammals which comprises administering to said mammal an amount of droloxifene or a pharmaceu... | 12/22/1998 |
| 5827892 | Use of droloxifene for the treatment of cardiovascular diseases Use of droloxifene in the treatment of cardiovascular diseases.... | 10/27/1998 |
| 5733937 | Methods for alleviating symptoms of premenstrual syndrome and late luteal phase dysphoric disorder The present invention provides novel methods of inhibiting the symptoms of premenstrual syndrome comprising administering to a human in need of treatment an effective amount of a compound of formula I ##STR1## wherein R1 and R2 ... | 03/31/1998 |
| 5719190 | Inhibition of myeloperoxidase activity The present invention provides novel methods of inhibiting myeloperoxidase activity comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1## wherein R1 and R2 may be ... | 02/17/1998 |
| 5719191 | 1,1,2-triphenylbut-1-ene derivatives for treating Alzheimer's disease The present invention provides novel methods of inhibiting Alzheimer's Disease comprising administering to a human in need of treatment an effective amount of a compound of formula I ##STR1## wherein R1 and R2 may be the same or... | 02/17/1998 |
| 5607959 | Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents Compounds of formula (I) where R1 is thienyl, phenyl or furyl, X and Y are halogen or hydrogen and Q is alkoxy or amino are useful as analgesic and antiinflamatory agents. ##STR1##... | 03/04/1997 |
| 5589366 | Process for producing antiparasitic macrolide antibiotics The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari, free-living nematodes and endo- and ectoparasites. This invent... | 12/31/1996 |
| 5589482 | Benzo-thiophene estrogen agonists to treat prostatic hyperplasia Benzothiophenes and related compounds of the formula ##STR1## are estrogen agonists which are useful for treating prostatic and diseases, obesity and bone loss in male animals.... | 12/31/1996 |
| 5573946 | Biologically pure culture of Streptomyces hygroscopicus ATCC 53718 capable of producing antibiotic compounds The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari, free-living nematodes and endo- and ectoparasites. This invent... | 11/12/1996 |
| 5552412 | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis Compounds of this formula ##STR1## are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.... | 09/03/1996 |
| 5510372 | Antiparasitic macrolide antiobiotics The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pest, acari, free-living nematodes and endo- and ectoparasites. This inventi... | 04/23/1996 |
| 5459145 | Calcium independent camp phosphodiesterase inhibitor antidepressant Antidepressant agents having the formula ##STR1## wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic het... | 10/17/1995 |
| 5441986 | Estrogen agonists as remedies for prostate and cardiovascular diseases Use of droloxifene in the treatment of benign prostatic hyperplasia, prostatic carcinoma and cardiovascular diseases.... | 08/15/1995 |
| 5436255 | Method of treating diseases susceptable to treatment by blocking NMDA-receptors 3-Piperidino-1-chromanol derivatives and analogs having the formula ##STR1## wherein A and B are taken together and are --CH2 CH2 -- or A and B are taken separately and are each H; X is CH2 or O; X1 is H or OH; ... | 07/25/1995 |
| 5420347 | Processes and intermediates for N-(S-3-alkyl-heptanoyl)-D-gamma-glutamyl-glycyl-D-alanine Immunoregulatory N-(S-3-alkyl-4-heptenoyl)- and N-(S-3-alkylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine and esters thereof are synthesized via R-trans-2-hexen-4-ols, R-3-alkyl-4-heptenoic acid and S-3-alkylheptanoic acid.... | 05/30/1995 |
| 5418231 | Pyrimido-benzothiazines This invention relates to novel pyrimido-benzothiazine derivative compounds. ##STR1## The compounds of the present invention inhibit the action of the lipoxygenase enzyme and are useful in the treatment or alleviation of inflammatory diseases, a... | 05/23/1995 |
| 5414127 | Calcium independent camp phosphodiesterase inhibitor antidepressant Antidepressant agents having the formula ##STR1## wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic het... | 05/09/1995 |
| 5401761 | Thiazolidinedione hypoglycemic agents Compounds of the formula ##STR1## where R is alkyl, cycloalkyl, phenyl or substituted phenyl are useful as hypoglycemic agents.... | 03/28/1995 |
| 5385916 | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents Certain 1-substituted 4-(1,2-benzisoxazolyl)-piperidine compounds exhibit neuroleptic activity and are useful in the treatment of psychosis and anxiety.... | 01/31/1995 |
