Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6362168 | Antiparasitic agents Compounds of the formula: ##STR1## wherein X represents a single or a double bond; R1 is H or OH; provided that when X is a single bond, R1 is H or OH, and when X is a double bond, R1 is absent; R2 is H, C1... | 03/26/2002 |
| 6103504 | Process for production of avermectins and cultures therefor This invention relates to Streptomyces avermitilis lacking branched-chain amino acid transaminase activity, branched-chain 2-oxo acid biosynthetic activity and, optionally and preferably, avermectin B-O-methyl transferase activity, methods for preparation... | 08/15/2000 |
| 5955297 | Expression plasmids for improved production of heterologous protein in bacteria Promoter-ribosome binding site (rbs) expression elements of general utility for high level heterologous gene expression; plasmids carrying said promoter-rbs expression elements and encoding genetic information for direct high level expression in bacteria ... | 09/21/1999 |
| 5919809 | 3-substituted-2-oxindole derivatives This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the pharmaceutically-acceptable salts thereof which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynt... | 07/06/1999 |
| 5840704 | Antiparasitic agents and process for their preparation The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R1 when taken individually is H or OH; R and R1 when taken together represent a double bond; R2 is an alpha-branch... | 11/24/1998 |
| 5821232 | Synergistic therapeutic compositions and methods This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this invention relates to synergistic compositions comprising amoun... | 10/13/1998 |
| 5763884 | Spectrophotometric analysis A method of and apparatus for spectrophotometric analysis of a powder material by reflectance measurements of a near infrared beam has a sample cell 2 within which the powder 20A is compressed between a spring biased plate 13 and a window 8 to a predeterm... | 06/09/1998 |
| 5760011 | Antibiotic macrolides Derivatives of 16-membered ring 3-deoxy macrolide antibiotic derivatives of rosaramicin, repromicin, 5-mycaminosyltylonolide, desmycosin, lactenocin, O-demethyllactenocin, cirramycin A1, and 23-deoxymycaminosyltylonolide, which are useful again... | 06/02/1998 |
| 5747465 | Sugar derivatives of macrolides This invention relates to the saccharide derivatives of macrocyclic compounds useful for the treatment of resistance to transplantion, autoimmune disease and fungal diseases.... | 05/05/1998 |
| 5739279 | Peptidyl 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid derivatives as antiinflammatory agents This invention relates to compounds of formula (A) which are derivatives of 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid and their pharmaceutically acceptable base salts. These derivatives and salts thereof are useful for inhibiting interleukin 1³... | 04/14/1998 |
| 5716967 | Isoxazoline compounds as antiinflammatory agents This invention relates to isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDEIV). The isoxazoline compounds are useful in inhibiting PDEIV and in the treatment of AIDS, asthma, arthritis, bronchitis... | 02/10/1998 |
| 5716939 | Amide derivatives of 16-membered ring antibiotic macrolides The present invention relates to amide derivatives of formula (I) or (II) of 19-carboxy-19-deformyl 16-membered ring macrolide antibiotics rosaramicin, repromicin, tylosin, 5-O-mycaminosyltylonolide, 4-deoxy-O-mycaminosyltylonolide, desmycosin lactenocin,... | 02/10/1998 |
| 5702924 | Process for preparing antiparasitic agents Compounds of the formula: ##STR1## wherein X represents a single or a double bond; R1 is H or OH; provided that when X is a single bond, R1 is H or OH, and when X is a double bond, R1 is absent; R2 is H, C | 12/30/1997 |
| 5693524 | Anticoccidial composition of UK-61 689 and Actinomadura mycelium Actinomadura roseorufa mutants characterized by the ability to produce by fermentation UK-61,689, an acidic polycyclic ether anticoccidial antibiotic previously available only by selective acid hydrolysis of UK-58,852; and Actinomadura roseorufa having th... | 12/02/1997 |
| 5679563 | Actinomadura roseorufa for making UK-61,689 Actinomadura roseorufa mutants characterized by the ability to produce by fermentation UK-61,689, an acidic polycyclic ether anticoccidial antibiotic previously available only by selective acid hydrolysis of UK-58,852; and Actinomadura roseorufa having th... | 10/21/1997 |
| 5663188 | Synergistic therapeutic compositions of angiotensin I converting enzyme inhibitors and angiotensin II antagonists and methods This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this invention relates to synergistic compositions comprising amoun... | 09/02/1997 |
| 5645647 | Modified polydextrose and process therefor An improved, water-soluble polydextrose containing 0.3 mol % or less of bound citric acid, a process therefor, and foods containing same.... | 07/08/1997 |
| 5643730 | Process for detecting specific mRNA and DNA in cells This invention relates to a process for detecting the presence and measuring the quantity of specific mRNA sequences present in in vivo cells or cells maintained in vitro. The process of this invention is applicable to the screening of procaryotic and euc... | 07/01/1997 |
| 5602012 | Microbiological process for making UK-61,689 Actinomadura roseorufa mutants characterized by the ability to produce by fermentation UK-61,689, an acidic polycyclic ether anticoccidial antibiotic previously available only by selective acid hydrolysis of UK-58,852; and Actinomadura roseorufa having th... | 02/11/1997 |
| 5583029 | Cultures for production of avermectin aglycones Mutants of Streptomyces avermitilis lacking ability to produce glycosylated avermectins and lacking branched-chain 2-oxo acid dehydrogenase activity, method for preparation thereof, and use thereof to produce natural and non-natural avermectin aglycones u... | 12/10/1996 |
| 5583015 | Process for production of avermectins Streptomyces avermitilis lacking branched-chain amino acid transaminase activity and/or branched-chain 2-oxo acid dehydrogenase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins useful as parasiticid... | 12/10/1996 |
| 5576199 | Process for production of B avermectins Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin B O-methyltransferase activity, method for preparation thereof, and use thereof to produce natural and non-natural B avermectins useful as parasiticides.... | 11/19/1996 |
| 5576200 | Process for production of avermectin aglycones and cultures therefor Mutants of Streptomyces avermitilis lacking ability to produce glycosylated avermectins and lacking branched-chain 2-oxo acid dehydrogenase activity, method for preparation thereof, and use thereof to produce natural and non-natural avermectin aglycones u... | 11/19/1996 |
| 5565359 | Cultures for production of B avermectins Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin B O-methyltransferase activity, method for preparation thereof, and use thereof to produce natural and non-natural B avermectins useful as parasiticides.... | 10/15/1996 |
| 5525506 | Process for production of avermectins and cultures therefor Streptomyces avermitilis lacking branched-chain amino acid transaminase activity and/or branched-chain 2-oxo acid dehydrogenase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins useful as parasiticid... | 06/11/1996 |
| 5451511 | Process for the preparation of antiparasitic agents The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R1 when taken individually is H or OH; R and R1 when taken together represent a double bond; R2 is an alpha-branch... | 09/19/1995 |
| 5446050 | Azabicyclo amides and esters as 5-HT3 receptor antagonists Novel azabicyclo amides and esters as antagonists at the 5-HT3 receptor and useful as anti-emetic agents.... | 08/29/1995 |
| 5391548 | Transdermal flux enhancing compositions to treat hypertension, diabetes and angina pectoris A transdermal flux enhancing pharmaceutical composition for transdermal administration to a human or lower animal subject comprising a safe and effective amount of a pharmacologically active compound or a prodrug thereof, an aqueous solvent system compris... | 02/21/1995 |
| 5387509 | Ethylated avermectins Avermectins wherein one or both of the 3'- and 3"-positions of the oleandrose disaccharide moiety is substituted by an ethoxy rather than a methoxy group, process for their preparation; and their use as antiparasitic agents.... | 02/07/1995 |
| 5300655 | 2-carboxy-thiophene derivatives This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H | 04/05/1994 |
| 5290802 | 3-substituted-2-oxindole derivatives This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H | 03/01/1994 |
| 5240850 | Cultures for production of avermectin aglycones Mutants of Streptomyces avermitilis lacking ability to produce glycosylated avermectins and lacking branched-chain 2-oxo acid dehydrogenase activity, method for preparation thereof, and use thereof to produce natural and non-natural avermectin aglycones u... | 08/31/1993 |
| 5238848 | Cultures for production of avermectins Streptomyces avermitilis lacking branched-chain amino acid transaminase activity and/or branched-chain 2-oxo acid dehydrogenase activity, methods for preparation thereof, and use thereof to produce natural and non-natural avermectins useful as parasiticid... | 08/24/1993 |
| 5234831 | Cultures for production of B avermectins Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin B O-methyltransferase activity, method for preparation thereof, and use thereof to produce natural and non-natural B avermectins useful as parasiticides.... | 08/10/1993 |
| 5233091 | 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor This invention relates to a novel process for preparing novel N-cyclopropyl intermediates useful for preparing certain of the 1,7-disubstituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives of this invention which contain a cyclopropyl su... | 08/03/1993 |
| 5210212 | Process for 5-fluoro-6-chlorooxindole Process for the production of 5-fluoro-6-chloro- oxindole, (III), which is useful in the synthesis of certain analgesic and antiinflammatory agents, via two different synthetic pathways. Compounds of formula (I) and (II) shown below ##STR1## which ar... | 05/11/1993 |
