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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7993928 | Detection of blood plasma Danshensu and Salvianolic acid B dissipating blood stasis botanical A detection method of blood plasma danshensu and salvianolic acid B of dissipating blood stasis botanical is disclosed. The method includes: (1) pretreating mammalian plasma sample: applying the plasma with medicine to small column of Waters Oasis HLB activated by m... | 08/09/2011 |
| 7989212 | Detection of blood plasma schizadrin B of dissipating blood stasis botanical A detection method of blood plasma schizadrin B of dissipating blood stasis botanical is disclosed. The method includes: (1) extracting schizadrin B from plasma of mammalian administered dissipating blood stasis botanical by ethyl acetate with the volume ratio 1:4, ... | 08/02/2011 |
| 7524643 | CDNA encoding the human alpha2 delta4 calcium channel subunit The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional α2δ-4 protein. The calcium channel α2δ-4 p... | 04/28/2009 |
| 7494768 | Mutational profiles in HIV-1 protease and reverse transcriptase correlated with phenotypic drug resistance The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic cha... | 02/24/2009 |
| 7473524 | Mutational profiles in HIV-1 protease correlated with phenotypic drug resistance The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention relates to the use of such genotypic characterization of a target populatio... | 01/06/2009 |
| 7465727 | (1,10B-dihydro-2-(aminoalkyl-phenyl)-5-pyrazolo[1,5-c][1,3]Benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors The present invention relates to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnost... | 12/16/2008 |
| 7427625 | Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute prote... | 09/23/2008 |
| 7384979 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which ... | 06/10/2008 |
| 7259146 | Neuroprotective peptides Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and... | 08/21/2007 |
| 7247474 | Monoclonal antibody which specifically binds to but does not activate the CD8 cells This invention provides a method of isolating CD8+ cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8+ cells but does not activate the CD8+ cells once bound. This invention also pr... | 07/24/2007 |
| 7235387 | Method for mutation detection in HIV-1 using pol sequencing The present invention relates to a method for mutation analysis of the HIV pol gene of HIV virions comprising amplifying virion RNA or DNA via nested PCR using outer primers as represented in SEQ ID No. 1 and 2, amplifying said PCR product via nested PCR using a 5â€... | 06/26/2007 |
| 7235215 | Capillary filler A capillary filling system automatically plucks capillaries from a capillary roll, and transports them to a filling station where the capillaries are filled with compounds. The filled capillaries are then fixed on a template where they are then ready to be used for ... | 06/26/2007 |
| 7232797 | Erythropoietin dosing regimen for treating anemia The present invention provides a new subcutaneous injection dosing regimen for erythropoietin to treat anemia. The new erythropoietin treatment regimen of the present invention results in improved hemoglobin levels with less frequent dosing. ... | 06/19/2007 |
| 7217506 | Mutational profiles in HIV-1 protease correlated with phenotypic protease inhibitor resistance The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention relates to the use of such genotypic characterization of a target populatio... | 05/15/2007 |
| 7206699 | Methods for measuring therapy resistance The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sam... | 04/17/2007 |
| 7189505 | Methods of assessing HIV integrase inhibitor therapy The present invention relates to methods and products for the evaluation of HIV treatment. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of the investigated compounds. The methods rely on providin... | 03/13/2007 |
| 7129036 | Reporter molecules and methods for assaying the lipidations status of a cell The invention relates to reporter molecules comprising at least one detection domain capable of emitting a signal and at least one membrane anchoring domain, which promotes the association of the reporter molecule with a membrane. The degree and rate of membrane ass... | 10/31/2006 |
| 7087375 | Method for determining the mechanism of HIV RT inhibitors The present invention is directed to the field of HIV resistance to RT inhibitors and methods of determining the levels and mechanisms of action of HIV resistance. The methods of the present invention may be accomplished using a novel in vitro assay that provides a ... | 08/08/2006 |
