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| Number | Title | Issue Date |
| 8178580 | Formulations and methods for treating amyloidosis Methods, formulations, and compositions for the treatment of amyloidosis are described. ... | 05/15/2012 |
| 8158636 | Compounds and methods for kinase modulation, and indications therefor Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivati... | 04/17/2012 |
| 8153772 | Oligonucleotide probes and primers comprising universal bases for diagnostic purposes Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease. ... | 04/10/2012 |
| 8153641 | Compounds and methods for kinase modulation, and indications therefor Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof derivativ... | 04/10/2012 |
| 8143271 | Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. ... | 03/27/2012 |
| 8133896 | Pyrimidine derivatives which are antagonist of the vitronectin receptor A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio... | 03/13/2012 |
| 8133669 | Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods a... | 03/13/2012 |
| 8129404 | Compounds and uses thereof N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-4-trifluoromethyl-benzenesulfonamide, N-[3-(4-ethynyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-4-trifluoromethyl-benzenesulfonamide, and salts thereof, formulations thereof, c... | 03/06/2012 |
| 8124390 | Aromatic prenyltransferases, nucleic acids encoding same and uses therefor In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation... | 02/28/2012 |
| 8119680 | α-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ... | 02/21/2012 |
| 8119637 | Substituted pyrrolo[2,3-b]pyrazines and methods for kinase modulation, and indications therefor Compounds active on Fms and/or Kit protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of Fms and/or Kit protein kinases, wherein the compounds have formula I: | 02/21/2012 |
| 8110576 | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described, wherein the compounds have the formula: In certain aspects and embodiments, the descr... | 02/07/2012 |
| 8106259 | Compositions and methods for plant genetic modification Mixed duplex oligonucleotides (MDON) are used to effect site-specific genetic alterations in a target DNA sequence of a plant. The MDON are introduced by electroporation into microspores. Thereafter, plants having a desired genetic alteration are produced by germina... | 01/31/2012 |
| 8071117 | Pheromones The apple leaf midge and raspberry cane midge pheromones have been found to be acetoxyheptadecenone and acetoxyundecanone, respectively, and uses for these and related compounds are provided, including monitoring population levels of the midge and control of midge p... | 12/06/2011 |
| 8067434 | Compounds and methods for development of Ret modulators Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for ex... | 11/29/2011 |
| 8067361 | Chaperonin 10 immunosuppression The invention is directed to the use of cpn10 in transplantation and particularly to treatment and/or prevention of graft versus host disease. The invention provides a method of administration of cpn10 to a donor and/or recipient animal or cells, tissues or organs d... | 11/29/2011 |
| 8053463 | PPAR active compounds Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula: | 11/08/2011 |
| 8029579 | Fatty acid blends and uses therefor Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a ... | 10/04/2011 |
| 8017629 | Compounds and uses thereof in modulating amyloid β Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ... | 09/13/2011 |
| 8013212 | Site-specific recombination in eukaryotes and constructs useful therefor Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in mice. Embryonic stem cells containing recombinase nucleic acid constructs that were expressed in the male germline would simplify curren... | 09/06/2011 |
| 7972782 | Steroid-activated nuclear receptors and uses therefor A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcripti... | 07/05/2011 |
| 7966133 | Method of identifying a potential substrates of an O-methyltransferase The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, met... | 06/21/2011 |
| 7947708 | Compounds modulating C-kit activity Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand ... | 05/24/2011 |
| 7923433 | Activity-based probes and methods of their preparation and use The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods d... | 04/12/2011 |
| 7896292 | Reactive component reduction system and methods for the use thereof In accordance with the present invention, there are provided simplified systems and methods for catalytically deactivating, removing, or reducing the levels of reactive component(s) from the vapor phase of fuel storage tanks. The simple apparatus described herein ca... | 03/01/2011 |
| 7893213 | Antibodies to activin receptor In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, ... | 02/22/2011 |
| 7846932 | Methods for the use of pyrimidine derivatives which are antagonists of vitronectin receptor A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio... | 12/07/2010 |
| 7862807 | Dendrimers as molecular translocators Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, ... | 01/04/2011 |
| 7825119 | Pyrimidine derivatives which are antagonists of vitronectin receptor A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio... | 11/02/2010 |
| 7807424 | Methods of producing polyketide synthase mutants and compositions and uses thereof The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acid encoding such non-native polyketide synthases. Also disclosed are ... | 10/05/2010 |
| 7799808 | α-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ... | 09/21/2010 |
| 7792645 | Three-dimensional structure of chalcone isomerase and methods of use thereof This disclosure provides crystalline flavonoid or flavanone isomerases, isolated non-native isomerase having the structural coordinates of said crystalline isomerase, and nucleic acids encoding such non-native isomerase. Also disclosed are methods of predicting the ... | 09/07/2010 |
| 7781442 | Compounds and uses thereof in modulating amyloid beta Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ... | 08/24/2010 |
| 7763621 | Vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparatio... | 07/27/2010 |
| 7741018 | Advantageous vitrifiable cryoprotectant mixtures Disclosed herein are aqueous carrier solutions for cryoprotectants that are useful for a variety of cryoprotectant solutions for use with cells, tissues, and whole organs, said aqueous carrier solutions permitting antinucleators to be fully effective in vitrificatio... | 06/22/2010 |
| 7723528 | Sulfur transfer reagents for oligonucleotide synthesis The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones as novel, efficient sulfur-transfer reagents is disclosed. The sulfur transfer from these reagents to compounds containing P(III) atom, triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopro... | 05/25/2010 |
| 7694916 | Catalytic reactive component reduction system and methods for the use thereof In accordance with the present invention, there are provided simplified systems and methods for catalytically deactivating, removing, or reducing the levels of reactive component(s) from the vapor phase of fuel storage tanks. The simple apparatus described herein ca... | 04/13/2010 |
| 7671085 | Non-steroidal farnesoid X receptor modulators and methods for the use thereof The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accord... | 03/02/2010 |
| 7647217 | Structure of the farnesoid X receptor ligand binding domain and methods of use therefor The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures ... | 01/12/2010 |
| 7618935 | Chaperonin 10 immunosuppression The invention is directed to the use of cpnl0 in transplantation and particularly to treatment and/or prevention of graft versus host disease. The invention provides a method of administration of cpn10 to a donor and/or recipient animal or cells, tissues or organs d... | 11/17/2009 |
