Reiter; Stephen E. - US Patent Attorneys and Agents

Attorney: Reiter; Stephen E.

Number of patents: 231
Last date: September 18, 2012

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Number	Title	Issue Date
8268858	Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. ...	09/18/2012
8264681	Methods and apparatus for remote Raman and laser-induced breakdown spectrometry An spectrometer including Raman and LIBS spectroscopy capabilities is disclosed. The spectrometer includes a laser source configurable to produce a lased light directable towards a target substance, the laser source having a single wavelength and having sufficient p...	09/11/2012
8247205	Chalcone isomerase polypeptides and crystals thereof This disclosure provides crystalline flavonoid or flavanone isomerases, isolated non-native isomerase having the structural coordinates of said crystalline isomerase, and nucleic acids encoding such non-native isomerase. Also disclosed are methods of predicting the ...	08/21/2012
8212006	Structure of the farnesoid X receptor ligand binding domain and methods of use therefor The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures ...	07/03/2012
8198273	Compounds and methods for kinase modulation, and indications therefor Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivati...	06/12/2012
8193274	Metal-clad laminates having improved peel strength and compositions useful for the preparation thereof In accordance with the present invention, compositions are described which are useful, for example, for the preparation of metal-clad laminate structures, methods for the preparation thereof, and various uses therefor. Invention metal-clad laminate structures are us...	06/05/2012
8187657	Prepared foods containing triglyceride-recrystallized non-esterified phytosterols A dietary supplement is provided which includes at least one triglyceride-based edible fat and between 3% and 50% by weight of triglyceride recrystallized phytosterols. The dietary supplement can be in the form of a capsule, pill or wafer. Additionally, the dietary ...	05/29/2012
8178580	Formulations and methods for treating amyloidosis Methods, formulations, and compositions for the treatment of amyloidosis are described. ...	05/15/2012
8158636	Compounds and methods for kinase modulation, and indications therefor Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivati...	04/17/2012
8153772	Oligonucleotide probes and primers comprising universal bases for diagnostic purposes Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease. ...	04/10/2012
8153641	Compounds and methods for kinase modulation, and indications therefor Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof derivativ...	04/10/2012
8143271	Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. ...	03/27/2012
8133896	Pyrimidine derivatives which are antagonist of the vitronectin receptor A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio...	03/13/2012
8133669	Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods a...	03/13/2012
8129404	Compounds and uses thereof N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-4-trifluoromethyl-benzenesulfonamide, N-[3-(4-ethynyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-4-trifluoromethyl-benzenesulfonamide, and salts thereof, formulations thereof, c...	03/06/2012
8124390	Aromatic prenyltransferases, nucleic acids encoding same and uses therefor In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation...	02/28/2012
8119680	α-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ...	02/21/2012
8119637	Substituted pyrrolo[2,3-b]pyrazines and methods for kinase modulation, and indications therefor Compounds active on Fms and/or Kit protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of Fms and/or Kit protein kinases, wherein the compounds have formula I:	02/21/2012
8110576	Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described, wherein the compounds have the formula: In certain aspects and embodiments, the descr...	02/07/2012
8106259	Compositions and methods for plant genetic modification Mixed duplex oligonucleotides (MDON) are used to effect site-specific genetic alterations in a target DNA sequence of a plant. The MDON are introduced by electroporation into microspores. Thereafter, plants having a desired genetic alteration are produced by germina...	01/31/2012
8071117	Pheromones The apple leaf midge and raspberry cane midge pheromones have been found to be acetoxyheptadecenone and acetoxyundecanone, respectively, and uses for these and related compounds are provided, including monitoring population levels of the midge and control of midge p...	12/06/2011
8067434	Compounds and methods for development of Ret modulators Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for ex...	11/29/2011
8067361	Chaperonin 10 immunosuppression The invention is directed to the use of cpn10 in transplantation and particularly to treatment and/or prevention of graft versus host disease. The invention provides a method of administration of cpn10 to a donor and/or recipient animal or cells, tissues or organs d...	11/29/2011
8053463	PPAR active compounds Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula:	11/08/2011
8029579	Fatty acid blends and uses therefor Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a ...	10/04/2011
8017629	Compounds and uses thereof in modulating amyloid β Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ...	09/13/2011
8013212	Site-specific recombination in eukaryotes and constructs useful therefor Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in mice. Embryonic stem cells containing recombinase nucleic acid constructs that were expressed in the male germline would simplify curren...	09/06/2011
7972782	Steroid-activated nuclear receptors and uses therefor A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcripti...	07/05/2011
7966133	Method of identifying a potential substrates of an O-methyltransferase The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, met...	06/21/2011
7947708	Compounds modulating C-kit activity Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand ...	05/24/2011
7923433	Activity-based probes and methods of their preparation and use The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods d...	04/12/2011
7896292	Reactive component reduction system and methods for the use thereof In accordance with the present invention, there are provided simplified systems and methods for catalytically deactivating, removing, or reducing the levels of reactive component(s) from the vapor phase of fuel storage tanks. The simple apparatus described herein ca...	03/01/2011
7893213	Antibodies to activin receptor In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, ...	02/22/2011
7846932	Methods for the use of pyrimidine derivatives which are antagonists of vitronectin receptor A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio...	12/07/2010
7862807	Dendrimers as molecular translocators Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, ...	01/04/2011
7825119	Pyrimidine derivatives which are antagonists of vitronectin receptor A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio...	11/02/2010
7807424	Methods of producing polyketide synthase mutants and compositions and uses thereof The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acid encoding such non-native polyketide synthases. Also disclosed are ...	10/05/2010
7799808	α-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ...	09/21/2010
7792645	Three-dimensional structure of chalcone isomerase and methods of use thereof This disclosure provides crystalline flavonoid or flavanone isomerases, isolated non-native isomerase having the structural coordinates of said crystalline isomerase, and nucleic acids encoding such non-native isomerase. Also disclosed are methods of predicting the ...	09/07/2010
7781442	Compounds and uses thereof in modulating amyloid beta Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ...	08/24/2010

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Attorney: Reiter; Stephen E.