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| Number | Title | Issue Date |
| 5750643 | Dehydrocoupling treatment and hydrosilylation of silicon-containing polymers, and compounds and articles produced thereby Novel methods for the preparation of polymers useful as precursors to ceramic materials by catalytic activation of Si--H bonds are disclosed. The methods comprise reacting, in the presence of a catalyst effective to activate Si--H bonds, Si--N bonds, or b... | 05/12/1998 |
| 5681532 | Optical sensors for the measurement of oxygen A ratiometric method for using optical sensors is provided to measure dissolved oxygen in a fluid sample. The sensor is formulated so as to contain an oxygen permeable membrane of a cured perfluorinated urethane polymer and, incorporated therein, an oxyge... | 10/28/1997 |
| 5639844 | Dehydrocoupling treatment and hydrosilylation of silicon-containing polymers, and compounds and articles produced thereby Novel methods for the preparation of polymers useful as precursors to ceramic materials by catalytic activation of Si--H bonds are disclosed. The methods comprise reacting, in the presence of a catalyst effective to activate Si--H bonds, Si--N bonds, or b... | 06/17/1997 |
| 5635250 | Hydridosiloxanes as precursors to ceramic products A method is provided for preparing ceramic precursors from hydridosiloxane starting materials and then pyrolyzing these precursors to give rise to silicious ceramic materials. Si--H bonds present in the hydridosiloxane starting materials are catalytically... | 06/03/1997 |
| 5633145 | TNF receptor-derived binding protein A polypeptide is provided which is capable of binding human TNF and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the group consisting... | 05/27/1997 |
| 5633098 | Batteries containing single-ion conducting solid polymer electrolytes Novel batteries containing single-ion conducting polymer electrolytes (SPEs) are provided. The polymers are polysiloxanes substituted with fluorinated poly(alkylene oxide) side chains having associated ionic species. The polymers have the following struct... | 05/27/1997 |
| 5632958 | Indicator containing perfluorinated polyurethane membranes for use in optical oxygen sensors A ratiometric method for using optical sensors is provided to measure dissolved oxygen in a fluid sample. The sensor is formulated so as to contain an oxygen permeable membrane of a cured perfluorinated urethane polymer and, incorporated therein, an oxyge... | 05/27/1997 |
| 5631340 | Cross-linked gas permeable membrane of a cured perfluorinated urethane polymer, and optical gas sensors fabricated therewith An optical sensor is provided for measuring dissolved gases such as O2 or CO2 in a fluid sample. The sensor is formulated so as to contain a gas permeable membrane of a cured perfluorinated urethane polymer and, incorporated therein,... | 05/20/1997 |
| 5630796 | Method of delivering powder transdermally with needless injector A needleless syringe having a membrane which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected. This provides effective transdermal delivery of the therapeutic agent.... | 05/20/1997 |
| 5625031 | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein Novel peptide and peptide mimetic ligands which act as inhibitors of p34cdc2 kinase, p33cdk2 kinase and human papillomavirus transforming protein E7 (HPV E7) are disclosed. The inhibitors are derived from the binding domains of a ret... | 04/29/1997 |
| 5622856 | High efficiency helper system for AAV vector production Novel nucleic acid molecules are provided having adeno-associated virus (AAV) coding regions that are capable of expressing necessary AAV functions to complement an AAV vector in the production of recombinant AAV (rAAV) virions. The molecules feature a nu... | 04/22/1997 |
| 5620849 | Methods and compositions for identifying inhibitors of papilloma virus replication Compositions and methods for identifying inhibitors of papilloma virus replication are described consisting of soluble cellular extracts supplemented with purified viral E1 and E2 proteins.... | 04/15/1997 |
| 5618959 | Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents A process for synthesizing prostaglandin E1, E2 and derivatives thereof is provided. The process is a "one-pot" method in which 2-furyllithium, copper cyanide, a lower alkyllithium reagent and either an (E)-alkenylstannane or a halog... | 04/08/1997 |
| 5611793 | Laser treatment A method of disinfecting or sterilizing tissues of the oral cavity or a wound or lesion in the oral cavity is provided. The method comprises applying a photosensitizing compound to said tissues, wound or lesion and irradiating said tissues, wound or lesio... | 03/18/1997 |
| 5607644 | Optical sensor for the measurement of pH in a fluid, and related sensing compositions and methods An optical sensor is provided for measuring the pH of a fluid sample. The sensor is formulated using a fluorescent polymer composition comprising a copolymer of a water-dispersable, polyether-containing urethane olefin precursor and a fluorescent monomer ... | 03/04/1997 |
| 5597807 | Quinoa saponin compositions and methods of use Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful as immunological adjuvants, to stimulate nonspecific immunity, as well as to enhance an immunological response to a selected antigen. The Quinoa saponin compositio... | 01/28/1997 |
| 5594107 | Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an... | 01/14/1997 |
| 5578615 | Method for treating herpes viral infections using benzothiophene analogs. Benzothiophene analogs useful to treat herpes viral infections, particularly cytomegalovirus, are provided. These antiviral agents have the structural formula (I) ##STR1## wherein R and R1 are as defined herein, and may be in free base or ... | 11/26/1996 |
| 5578462 | NF2 isoforms Novel human and mouse NF2 transcript isoforms and proteins encoded thereby, are disclosed. The isoforms are found in a variety of tissue and tumor types and represent differential processing of genomic DNA sequences, at the level of transcription, resulti... | 11/26/1996 |
| 5545548 | Thermally stable cytosine deaminase from saccharomyces Thermally stable cytosine deaminase (CDase), and the gene coding therefor, is disclosed as well as methods of isolating, purifying, and recombinantly producing the same. The thermally stable CDase can be isolated from Saccharomyces cerevisiae. The yeast i... | 08/13/1996 |
| 5536783 | Fluorescent polymers useful in conjunction with optical PH sensors An optical sensor is provided for measuring the pH of a fluid sample. The sensor is formulated using a fluorescent polymer composition comprising a copolymer of a water-dispersable, polyether-containing urethane olefin precursor and a fluorescent monomer ... | 07/16/1996 |
| 5534256 | Haemophilus somnus outer membrane protein extract enriched with iron-regulated proteins New subunit vaccines from Haemophilus somnus are disclosed. The vaccines include an outer membrane protein extract of H. somnus which is enriched with iron-regulated proteins. Additional antigens, such as antigens derived from Pasteurella haemolytica, can... | 07/09/1996 |
| 5532225 | Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods Acyclic purine phosphonate nucleotide analogs useful to treat herpes viral infections are provided in enantiomerically pure form. These antiviral agents have the structural formula (Ia) or (Ib) ##STR1## and may be in acid, salt or ester form. Such co... | 07/02/1996 |
| 5521084 | Bovine heat shock promoter and uses thereof A novel expression system using the heat-inducible bovine hsp70A promoter and associated cis-acting elements is disclosed. The system provides for the continuous production of a highly pure, authentic protein, substantially free of infectious viral and ce... | 05/28/1996 |
| 5521077 | Method of generating multiple protein variants and populations of protein variants prepared thereby A method based on generalized recombination is provided for generating multiple protein variants. The method involves introducing into host cells at least two pools of mutant encoding nucleotide sequences, recipient and donor, transducing the donor pool i... | 05/28/1996 |
| 5521072 | Actinobacillus pleuropneumoniae transferrin binding proteins and uses thereof Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae cytolysin and/or one A. pleuropneumoniae APP4. Also disclosed ar... | 05/28/1996 |
| 5518710 | Methods for extracting cereal ଲ-glucans Simple and efficient methods for extracting high levels of ଲ-glucans from cereal sources are disclosed. The method employs a strong base, such as sodium hydroxide as an initial solvent. If desired, the extract can be further purified to render a &#x... | 05/21/1996 |
| 5510340 | Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain, R1 is --OH, .dbd.O, or the like, and X and Y are N, N.fwdarw.O, CH, C--OH, C--OCH | 04/23/1996 |
| 5501947 | PCR diagnosis of human papilloma virus type 16 The invention provides oligonucleotides (A): and (B): and their derivatives. These oligos may be used as a pair of primers for the detection of HPV16 (SEQ ID NO:3) DNA in a sample, without false positives arising due to the presence of other HPV strains. ... | 03/26/1996 |
| 5498477 | N-phenylhydroxylamine polymers, and associated methods of preparation and use Electroactive polymers are provided which contain alternating phenyl rings and nitrogen atoms, and which contain both quinoid mer units and benzenoid mer units. The polymers are formed by poly(condensation) of N-phenylhydroxylamine or derivatives thereof ... | 03/12/1996 |
| 5482039 | Process for diagnosing erectile dysfunction, and related methods of treatment A method for diagnosing vasculogenic erectile dysfunction, including vasculogenic impotence and Peyronie's syndrome, is provided. The method involves transurethral administration of a vasodilating agent to induce an erection, followed by hemodynamic evalu... | 01/09/1996 |
| 5480723 | Surface-bound fluorescent polymers and related methods of synthesis and use A fiber optic sensing device for measuring a chemical or physiological parameter of a body fluid or tissue is provided. To one end of the fiber is attached a polymer including a plurality of photoactive moieties selected from the group consisting of chrom... | 01/02/1996 |
| 5476657 | Pasteurella haemolytica leukotoxin compositions and uses thereof New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. ha... | 12/19/1995 |
| 5466861 | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R1, R2, R3, R4, R5 and n are as defined herein. The novel compounds are useful for modulating gene expression of ... | 11/14/1995 |
| 5464936 | Compositions for identification of papillomavirus replication inhibitors Medicaments, and methods of identifying the same, are described that are useful for treating papillomavirus diseases that have the characteristics of preventing, interfering with, or reversing the binding of the appropriate papillomavirus proteins E1 or E... | 11/07/1995 |
| 5462880 | Ratiometric fluorescence method to measure oxygen A ratiometric method for using optical sensors is provided to measure dissolved oxygen in a fluid sample. The sensor is formulated so as to contain an oxygen permeable membrane of a cured perfluorinated urethane polymer and, incorporated therein, an oxyge... | 10/31/1995 |
| 5453248 | Cross-linked gas permeable membrane of a cured perfluorinated urethane polymer, and optical gas sensors fabricated therewith An optical sensor is provided for measuring dissolved gases such as O2 or CO2 in a fluid sample. The sensor is formulated so as to contain a gas permeable membrane of a cured perfluorinated urethane polymer and, incorporated therein,... | 09/26/1995 |
| 5441736 | Actinobacillus pleuropneumoniae outer membrane lipoprotein A and uses thereof Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one Actinobacillus pleuropneumoniae outer membrane lipoprotein A, or an immunogenic fragment thereof. Also disclosed are DNA sequences encoding the... | 08/15/1995 |
| 5424315 | Benzothiophen analogs as antiviral agents Benzothiophene analogs useful to treat herpes viral infections, particularly cytomegalovirus, are provided. These antiviral agents have the structural formula (I) ##STR1## wherein R and R1 are as defined herein, and may be in free base or ... | 06/13/1995 |
| 5422110 | Enhanced immunogenicity using leukotoxin chimeras New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase ... | 06/06/1995 |
