Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 7052594 | Devices and methods for controlling fluid flow using elastic sheet deflection The invention relates to devices that control fluid flow, which comprise a substrate having an upper surface adapted to contact a flowing fluid and an elastic sheet immobilized with respect to the substrate, typically at a minimum of two immobilization points. The e... | 05/30/2006 |
| 6893836 | Spatially directed ejection of cells from a carrier fluid This invention is directed to the use of focused energy, particularly focused acoustic energy, in the spatially directed ejection of cells suspended in a carrier fluid, e.g., for providing a pattern of cells on a substrate surface, such as a cellular array. ... | 05/17/2005 |
| 6890703 | Preparation of crosslinked particles from polymers having activatible crosslinking groups Crosslinked particles are provided that are useful in the manufacture of dielectric materials for use in electronic devices such as integrated circuits. The crosslinked particles are prepared by activating crosslinkable groups on synthetic polymer molecules, where t... | 05/10/2005 |
| 6884859 | Ring-opening metathesis polymerization of bridged bicyclic and polycyclic olefins containing two or more heteroatoms A method is provided for synthesizing a polymer in a controlled fashion using a ring-opening metathesis polymerization (ROMP) reaction, wherein polymerization is carried out using a catalytically effective amount of an olefin metathesis catalyst and a bridged bicycl... | 04/26/2005 |
| 6849423 | Focused acoustics for detection and sorting of fluid volumes A method is provided for acoustically ejecting from a channel or other container a plurality of fluid droplets, each of which contains one or more particles or other localized volumes. The localized volumes, which can be living cells, are ejected towards sites on a ... | 02/01/2005 |
| 6835392 | Dual enhancer composition for topical and transdermal drug delivery A permeation enhancer composition is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The composition is comprised of a hydroxide-releasing agent and a l... | 12/28/2004 |
| 6833478 | N,N-dinitramide salts as solubilizing agents for biologically active agents A method is provided for enhancing the solubility of an ionizable compound in a lipophilic medium by admixing the compound with an effective solubility-enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically... | 12/21/2004 |
| RE38676 | Thermally initiated polymerization of olefins using ruthenium or osmium vinylidene complexes The present invention generally relates to the use of certain ruthenium and osmium complexes that are substantially inactive at a first temperature (preferably about room temperature) but becomes progressively more active at a higher second temperature. This differe... | 12/21/2004 |
| 6821523 | Topical administration of pharmacologically active bases in the treatment of warts Provided are methods and topical pharmaceutical formulations for use in the treatment of warts. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5... | 11/23/2004 |
| 6814289 | Self-registering spread-spectrum barcode method A novel spread spectrum barcode methodology is disclosed that allows a barcode to be read in its entirety even when a significant fraction or majority of the barcode is obscured. The barcode methodology makes use of registration or clocking information that is distr... | 11/09/2004 |
| 6815064 | Luminescent nanoparticles and methods for their preparation Methods for synthesizing luminescent nanoparticles and nanoparticles prepared by such methods are provided. The nanoparticles are prepared by a method in which an additive is included in the reaction mixture. The additive may be a Group 2 element, a Group 12 element... | 11/09/2004 |
| 6812551 | Defect-free dielectric coatings and preparation thereof using polymeric nitrogenous porogens Defect-free dielectric coatings comprised of porous polymeric matrices are prepared using nitrogen-containing polymers as pore-generating agents. The dielectric coatings are useful in a number of contexts, including the manufacture of electronic devices such as inte... | 11/02/2004 |
| 6808934 | High-throughput biomolecular crystallization and biomolecular crystal screening The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization experiments. Such arrays may utilize very small fluid volumes, in the order... | 10/26/2004 |
| 6809315 | Method and system using acoustic ejection for preparing and analyzing a cellular sample surface The invention relates to a method and system for acoustically depositing a fluid on a surface of a cell sample. A reservoir containing a fluid is provided, and the cell sample surface is positioned in droplet-receiving relationship to the reservoir. Once the reservo... | 10/26/2004 |
| 6806325 | High metathesis activity ruthenium and osmium metal carbene complexes Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene ... | 10/19/2004 |
| 6806051 | Arrays of partially nonhybridizing oligonucleotides and preparation thereof using focused acoustic energy Partially nonhybridizing oligonucleotides are provided that contain two or more hybridizing segments, with any two hybridizing segments separated by a nonhybridizing spacer segment, i.e., a nucleotidic or nonnucleotidic segment that has little or no likelihood of bi... | 10/19/2004 |
| 6803429 | Selective ring-opening cross-metathesis of cycloolefins A catalytic method is provided for a ring-opening cross-metathesis reaction between a cycloolefinic substrate and a second olefinic reactant, wherein the catalyst used is a transition metal alkylidene complex substituted with an N-heterocyclic carbene ligand. The su... | 10/12/2004 |
| 6802593 | Acoustic ejection of fluids from a plurality of reservoirs The present invention provides a method and device for the acoustic ejection of fluid droplets from each of a plurality of fluid-containing reservoirs. The droplets are ejected toward sites on a substrate surface for deposition thereon. The device is comprised of: a... | 10/12/2004 |
| 6803420 | Two-phase, water-absorbent bioadhesive composition An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polym... | 10/12/2004 |
| 6801804 | Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis The invention provides a device for iontophoretically transporting a compound through a localized region of an individual's body tissue. The device comprises first and second iontophoretic electrodes, a reference electrode, a current source, and a monitoring means. ... | 10/05/2004 |
| 6800655 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the compounds are selected to enhance the compounds' overall efficacy, particula... | 10/05/2004 |
| 6800722 | Electroluminescent polymers and use thereof in light-emitting devices The invention provides conjugated polymers that have good solubility and semiconductivity, and that display high photoluminescent and electroluminescent efficiency. Representative polymers containing monomer units having the general structure of formula (I): | 10/05/2004 |
| 6794534 | Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the s... | 09/21/2004 |
| 6794110 | Polymer blend and associated methods of preparation and use A polymer blend is provided for use in a lithographic photoresist composition, particularly a chemical amplification photoresist. In a preferred embodiment, the polymer blend is substantially transparent to deep ultraviolet radiation, i.e., radiation of a wavelength... | 09/21/2004 |
| 6784323 | Enantioselective transformation of α,β-unsaturated aldehydes using chiral organic catalysts Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of α,β-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) o... | 08/31/2004 |
| 6783699 | Europium-containing fluorescent nanoparticles and methods of manufacture thereof Europium-containing fluorescent nanoparticles and methods of preparing such nanoparticles are provided. The nanoparticles are comprised of an aluminum oxide framework having a europium activator, a magnesium, calcium, strontium, or barium energy reservoir, and at le... | 08/31/2004 |
| 6784170 | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or... | 08/31/2004 |
| 6780492 | Substrates prepared by chemical amplification of self-assembled monolayers with spatially localized polymer brushes A method is disclosed for providing a patterned surface wherein predetermined regions of the surface are masked with a self-assembled monolayer (“SAM”) covalently bound to a brush polymer overlayer. The remainder of the substrate surface will generally be functi... | 08/24/2004 |
| 6776921 | Composition for textile printing The present invention features novel methods and compositions for coating textile substrates, wherein the coating compositions are composed of a coating agent selected from one of (a) an azetidinium polymer, (b) a guanidine polymer, (c) a mixture of an azetidinium p... | 08/17/2004 |
| 6761977 | Treatment of substrates to enhance the quality of printed images thereon using azetidinium and/or guanidine polymers Compositions and methods are provided for improving the quality of images printed on a substrate. The novel image-enhancing compositions contain as an image-enhancing agent (a) an azetidinium polymer, (b) a guanidine polymer, (c) a mixture of an azetidinium polymer ... | 07/13/2004 |
| 6746104 | Method for generating molecular arrays on porous surfaces The present invention provides a unique and highly accurate method for generating molecular arrays of very high density on porous surfaces. The method involves the application of focused acoustic energy to each of a plurality of fluid-containing reservoirs to eject ... | 06/08/2004 |
| 6747018 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety w... | 06/08/2004 |
| 6737504 | Synthesis of substituted poly(aniline)s A method for preparing a wide range of substituted poly(aniline)s from a single precursor is described. The method uses a variety of reactions, including a boron activation/electrophilic displacement reaction resulting in ipso-substitution. The ability to tune the p... | 05/18/2004 |
| 6734436 | Optical microfluidic devices and methods The invention relates to microfluidic devices and methods that employ electromagnetic radiation to move a droplet of fluid on a fluid-transporting surface of a substrate. Typically, radiation of a particular wavelength is directed through a substantially transparent... | 05/11/2004 |
| 6730452 | Lithographic photoresist composition and process for its use A lithographic photoresist composition is provided that can be used as a chemical amplification photoresist. In a preferred embodiment, the composition is substantially transparent to deep ultraviolet radiation, i.e., radiation of a wavelength less than 250 n... | 05/04/2004 |
| 6723828 | Conjugated electroluminescent polymers and associated methods of preparation and use The invention provides conjugated polymers that have good solubility and semiconductivity, and that display high photoluminescent and electroluminescent efficiency. Representative polymers have the structure of formula (I): ... | 04/20/2004 |
| 6723383 | Preparation of images on a substrate surface utilizing an opaque coating composition that becomes transparent upon printing The present invention features processes and compositions for producing a metallic-looking image on a substrate having a reflective or luminescent surface. The process utilizes an opaque coating composition containing an opaque coating agent comprising a mixture of ... | 04/20/2004 |
| 6719997 | Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers Methods, compositions and drug delivery systems are provided for the transdermal administration of a pharmacologically active amine. The active agent is administered with a hydroxide-releasing agent that serves as a permeation enhancer. Exemplary hydroxide-releasing... | 04/13/2004 |
| 6720442 | Preparation of phosphorus-containing compounds useful in the preparation of biphosphine ligands This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents a... | 04/13/2004 |
| 6710335 | Acoustic sample introduction for analysis and/or processing The invention relates to the efficient transport of a small volume of fluid, such as may be required by mass spectrometers and other devices configured to process and/or analyze small samples of biomolecular fluids. Such transport involves nozzleless acoustic ejecti... | 03/23/2004 |
