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| Number | Title | Issue Date |
| 4883816 | Antihypertensive derivatives Antihypertensive sulfonyl derivatives having the following formula are described: ##STR1## where R" is a C2 -C20 alkyl group, R"1 is a C1 to C4 alkyl group, y is an integer from 2 to 10 and J- | 11/28/1989 |
| 4816247 | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs Lipid emulsion form compositions have been formulated and presented to eliminate adverse injection site reactions associated with the intravenous administration of certain sparingly water soluble, hydrophobic, ionizable drugs in mammals and to provide a s... | 03/28/1989 |
| 4784845 | Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs This disclosure describes quick breaking, in vivo, intravenous, intramuscular, intraarticular fat emulsion compositions which incorporate the use of benzyl alcohol as a consurfactant and/or a cosolvent in combination with materials such as synthetic surfa... | 11/15/1988 |
| 4760157 | (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes Novel organic-platinum compounds selected from those of the formulae: ##STR1## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken togeth... | 07/26/1988 |
| 4746662 | Treatment of arthritis with 3,5-dichloromethotrexate Joint destruction associated with arthritic disease in warm blooded animals is treated with unexpected safety using 3,5-dichloromethotrexate. The therapeutic index therefor is unexpectedly enhanced through combination therapy using a post administration o... | 05/24/1988 |
| 4728663 | N-[(1H-imidazol-1-yl)alkyl]benz[cd]-indol-2-amines and use in inhibiting thromboxane synthetase enzyme N-[(1H-imidazol-1-yl)alkyl]benz[cd]-indol-2 amines useful as inhibitors of thromboxane synthetase enzyme, hypotensive agents and cardioprotective agents are described.... | 03/01/1988 |
| 4705686 | Process for the preparation of acellular Bordetalla pertussis vaccine This invention discloses a process for preparing an acellular Bordetella pertussis vaccine by passing culture supernatants or cellular extracts of B. pertussis through a column containing an ion exchange resin. The eluate from the column is detoxified and... | 11/10/1987 |
| 4703130 | Antihypertensive phosphate derivatives Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein W is selected from the group consisting of methyl and phenyl optionally substituted with C1 -C3 alkyl, C1 -C3 | 10/27/1987 |
| 4699786 | Enhanced large scale cultivation of bordetella pertussis cells for vaccine production using lactoglobulin A Bordetella pertussis vaccine is prepared by deep tank cultivation using a seed grown in a biphasic culture system. An anion exchange resin in combination with ଲ-lactoglobulin and a Modified Cohen-Wheeler or Modified Stainer-Schlolte medium is used... | 10/13/1987 |
| 4699990 | Antihypertensive phosphate derivatives Antihypertensive phosphate derivatives are described having the following formula: ##STR1## wherein n is an integer 1 or 2; m is an integer 1 or 2, and the sum of n and m must be 3; X is selected from the group consisting of C1 -C | 10/13/1987 |
| 4696936 | 3,6-bis (substituted) acridine N-oxides and N,N-dioxides and methods of restoring, stimulating or enhancing the immune system with them This invention concerns novel 3,6-bis(substituted) acridine N-oxides and N,N-dioxides which are active as modulators of the immune system in warm-blooded animals.... | 09/29/1987 |
| 4697031 | Antihypertensive phosphate derivatives Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is selected from the group consisting of a phenyl radical substituted at any position with a C1 -C20 branched or straight ... | 09/29/1987 |
| 4569934 | Imidazo[1,2-b]pyridazines This invention concerns novel imidazo[1,2-b]-pyridazines and their use as agents for treating anxiety.... | 02/11/1986 |
| 4518790 | 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners This disclosure describes novel 15-deoxy-16-hydroxy-16- substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion, and particularly, alkyl ester... | 05/21/1985 |
