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| Number | Title | Issue Date |
| 6825332 | Gene related to migraine in man Genes for familial hemeplegic migraine (FHM), episodic ataxia type-2 (EA-2), common forms of migraine, and other episodic neurological disorders, such as epilepsy, have been mapped to chromosome 19p13. A brain-specific P/Q type calcium channel subunit gene, covering... | 11/30/2004 |
| 6475508 | Methods and pharmaceutical compositions for the closure of retinal breaks Described are compositions, methods, and articles of manufacture for the closure of retinal breaks with a non-toxic polymer. Transformation to a gel-like coat is achieved by photochemical reactivity, chemical reactivity, and by physicochemical response.... | 11/05/2002 |
| 6472415 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind ... | 10/29/2002 |
| 6358699 | Assay for asymmetrical NG, NG dimethyl-l-arginine ADMA is determined in a physiological sample by first removing interfering components: proteins by precipitation; and amines and citrulline, by means of a cation exchange column, followed by enzymatic hydrolysis of the ADMA to citrulline with DDAH. The ci... | 03/19/2002 |
| 6350576 | Cancer detection probes Nucleic acid sequence probes are provided for the detection of lesions associated with neoplastic cells. The sequences can be used for identifying the locus associated with the lesion, for determining cancer susceptibility of cells, as well as categorizin... | 02/26/2002 |
| 6319693 | Cloning of chicken anemia virus DNA Recombinant genetic information (DNA or RNA), comprising a Chicken Anemia Virus (CAV)-specific nucleotide sequence and the use thereof for diagnostics, vaccination or protein production. Recombinant CAV protein and the use thereof for diagnostics, vaccina... | 11/20/2001 |
| 6300493 | Method and compositions for modification of polysaccharide characteristics Methods and compositions are provided for the modification of polysaccharide structures using polysaccharidase binding or catalytic domains either alone or in tandem to modify the structure of polysaccharides. These methods and compositions are exemplifie... | 10/09/2001 |
| 6288301 | Treatment for juvenile diabetes A method for treating diabetes mellitus by administering composition providing a gastrin/CCK receptor ligand, e.g. a gastrin, and an EGF receptor ligand, e.g. TGF, in an amount sufficient to effect differentiation of pancreatic islet precursor cell... | 09/11/2001 |
| 6277606 | Representational approach to DNA analysis Methodology is provided for developing probes for identifying sequence differences between two related DNA populations, sets of DNA fragments or collections of restriction-endonuclease-cleaved DNA or cDNA. The method employs an initial stage to obtain a r... | 08/21/2001 |
| 6222097 | Use of ovary-tissue transcriptional factors for altering plant color Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in ovary tissue, particularly in very early fruit development. The DNA constru... | 04/24/2001 |
| 6184249 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind ... | 02/06/2001 |
| 6176962 | Methods for fabricating enclosed microchannel structures Methods are provided for the fabrication of polymeric microchannel structures having enclosed microchannels of capillary dimension. The microchannel structures are constructed of a base plate and a cover, sealed together. Microchannel structures having wa... | 01/23/2001 |
| 6162461 | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. The immunogenic properties of the chicken anemia virus (CAV) proteins produced separately or toge... | 12/19/2000 |
| 6140486 | Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes ... | 10/31/2000 |
| 6124528 | Modification of soluble solids in fruit using sucrose phosphate synthase encoding sequence This invention relates to methods for the expression of sucrose phosphate synthase encoding sequences alone or in cooperation with sugar metabolizing enzyme sequences to modify the soluble solids in plant fruit tissue. Depending on whether sense or antise... | 09/26/2000 |
| 6123928 | Sunblocking polymers and their novel formulations Novel polymeric biologically inert compositions and their intermediates, as well as sunscreen formulations comprising them and making them invisible, are provided for broad range protection from ultraviolet radiation. Acryl polymers comprising at least tw... | 09/26/2000 |
| 6117872 | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity NO precursors are administered at elevated levels in addition to the diet of the individual to enhance exercise performance. Particularly, L-arginine and L-lysine by enhancing endothelial NO production can provide for greater aerobic capacity and improved... | 09/12/2000 |
| 6103537 | Capillary assays involving separation of free and bound species The present invention concerns methods for masking inhomogeneity of a member of a specific binding pair (sbp) employed in a capillary electroseparation. The method comprises binding the sbp member to synthetic particles that become localized during capill... | 08/15/2000 |
| 6103199 | Capillary electroflow apparatus and method The present invention concerns an apparatus for conducting a microfluidic process. The apparatus comprises integral first and second plates. The first plate comprises an array of sample receiving elements for receiving a plurality of samples from an array... | 08/15/2000 |
| 6096547 | Method and transgenic plant for producing mammalian peptides Constructs are provided for expression of physiologically active mammalian proteins in plant cells, either in culture or under cultivation. The constructs provide a promoter functional in a plant host, a structural gene coding for mammalian protein and a ... | 08/01/2000 |
| 6093296 | Method and device for moving molecules by the application of a plurality of electrical fields Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of time so as to move the charged molecules through the medium... | 07/25/2000 |
| 6074827 | Microfluidic method for nucleic acid purification and processing Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that waste fluid ... | 06/13/2000 |
| 6072069 | Biodegradable nonionic contrast media Novel non-ionic contrast media are provided, which fulfill the requirements for x-ray visualization media, while being biodegradable. The compounds are characterized by being triiodo-3,5-diaminobenzoic acid derivatives, where the functional groups are der... | 06/06/2000 |
| 6063432 | Arginine or lysine containing fruit healthbar formulation Health bars are provided having high dosages of at least one of the amino acids L-arginine and L-lysine in conjunction with fruit solids and paste, protein and carbohydrates. A number of different fruit sources may be used, grapes finding particular use, ... | 05/16/2000 |
| 6054034 | Acrylic microchannels and their use in electrophoretic applications Microchannels having at least an acrylic inner surface and methods of their use in electrophoretic applications are provided. The subject microchannels may be in the form of a variety of configurations suitable for holding an electrophoretic medium. The s... | 04/25/2000 |
| 6048715 | Two-phase partition affinity separation system and affinity separated cell-containing composition A two-phase partition system is provided for affinity separation of a composition containing a polysaccharide binding peptide from a mixture such as a fermentation broth. The peptide may be from an enzyme and lacking in polysaccharidase activity such as t... | 04/11/2000 |
| 6046455 | Integrating ultraviolet exposure detection devices Diyne monomers are used as photochromic agents in devices or formulations. The devices and formulations may be applied to body parts for semi-pemanent attachment at various sites to allow for detection of levels of ultraviolet radiation. Clear films may b... | 04/04/2000 |
| 6033908 | Packaging systems for human recombinant adenovirus to be used in gene therapy The invention provides improved methods and products based on adenoviral materials which can advantageously be used in for instance gene therapy. In one aspect an adenoviral vector is provided which has no overlap with a suitable packaging cell line which... | 03/07/2000 |
| 6007690 | Integrated microfluidic devices Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that waste fluid ... | 12/28/1999 |
| 5981502 | Methods and compositions for inducing apoptosis in tumor cells Novel proteins of the Chicken Anemia Virus are described and compositions for preventing or treating infections with that virus (CAV), in particular vaccines less pathogenic than the CAV itself, but yet leading to neutralizing antibodies in the immunized ... | 11/09/1999 |
| 5972604 | DNA sequence-based HLA typing method The present invention provides a process for determining genotypes in highly polymorphic systems by polymerase chain reaction amplification of CDNA or genomic DNA and direct sequencing polymerase chain reaction products using oligonucleotide primers. More... | 10/26/1999 |
| 5962289 | Polysaccharide binding fusion proteins and conjugates Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a ଲ-1,4-glycan matrix such as cellulose. The substrate binding region is essentially... | 10/05/1999 |
| 5958424 | Recombinant chicken anemia virus particle Recombinant genetic information (DNA or RNA), comprising a Chicken Anemia Virus (CAV)-specific nucleotide sequence and the use thereof for diagnostics, vaccination or protein production. Recombinant CAV protein and the use thereof for diagnostics, vaccina... | 09/28/1999 |
| 5958881 | Composition containing VIP for injection and a method of enhancing visualization of tissues during medical procedures A method of inducing a temporary substantial paralysis of an area of interest in a patient undergoing a medical procedure is provided. The method involves administering a therapeutically effective amount of vasoactive intestinal peptide (VIP) admixed with... | 09/28/1999 |
| 5952002 | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor Novel proteins of the Chicken Anemia Virus are described and compositions for preventing or treating infections with that virus (CAV), in particular vaccines less pathogenic than the CAV itself, but yet leading to neutralizing antibodies in the immunized ... | 09/14/1999 |
| 5932476 | Cloning of chicken anemia virus DNA Recombinant genetic information (DNA or RNA), comprising a Chicken Anemia Virus (CAV)-specific nucleotide sequence and the use thereof for diagnostics, vaccination or protein production are described. Recombinant CAV protein and the use thereof for diagno... | 08/03/1999 |
| 5928917 | Conjugate of non-protein chemical moiety and polypeptide having cellulose binding region Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a ଲ-1,4-glycan matrix such as cellulose. The substrate binding region is essentially... | 07/27/1999 |
| 5922600 | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1 VP2 and VP3 or sequences of that virus coding therefor The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. The immunogenic properties of the chicken anemia virus (CAV) proteins produced separately or toge... | 07/13/1999 |
| 5914446 | Soluble solids modification using sucrose phosphate synthase encoding sequences This invention relates to methods for the utilization of sucrose phosphate synthase encoding sequences to modify the soluble solids in plant sink tissue. The method permits an increase in the sweetness of tomato fruit.... | 06/22/1999 |
| 5885956 | Treatment for diabetes using a gastrin/CCK receptor ligand and an EGF receptor ligand A method for treating diabetes mellitus by administering composition providing a gastrin/CCK receptor ligand, e.g. a gastrin, and an EGF receptor ligand, e.g. TGF, in an amount sufficient to effect differentiation of pancreatic islet precursor cell... | 03/23/1999 |
