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| Number | Title | Issue Date |
| 8183012 | Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are al... | 05/22/2012 |
| 8181043 | Methods and apparatus for improved remotely switchable power supply Methods and apparatus systems for remotely controllable power supplies for various network devices in various situations. ... | 05/15/2012 |
| 8173424 | Internalizing ErbB2 antibodies This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F... | 05/08/2012 |
| 8173393 | Expanding the eukaryotic genetic code This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of... | 05/08/2012 |
| 8173392 | In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... | 05/08/2012 |
| 8173364 | Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are al... | 05/08/2012 |
| 8164492 | Apparatus and method for fast data encoding and decoding An improved method for encoding and decoding data, such as in a base64 system, uses multiple look-up tables to perform the encoding function and to eliminate or reduce bit-shifting and the bit masks in encoding systems through use of pre-populated look-up tables. On... | 04/24/2012 |
| 8145544 | Method and system for demand and supply map/shopping path model graphical platform and supplying offers based on purchase intentions Methods and systems allowing a consumer to use a graphical tool that summarizes, compares and browses multiple offers for products or services over a network or communications medium such as via the Internet. In specific embodiments, potential purchasers can make de... | 03/27/2012 |
| 8139833 | Analyzing large data sets using a computer system A method and/or system for making determinations regarding samples from biologic sources. A computer implemented method and/or system can be used to automate parts of the analysis. ... | 03/20/2012 |
| 8129587 | seeds and plants with reduced expression of the ACS2 gene The enzymes of the ACC synthase family are used in producing ethylene. Nucleotide and polypeptide sequences of ACC synthases, namely ACS2, ACS6, and ACS7 from Zea mays, are provided. Knockout plant cells having inhibition in expression and/or activity in an A... | 03/06/2012 |
| 8124860 | seeds and plants with reduced expression of the ACS6 gene The enzymes of the ACC synthase family are used in producing ethylene. Nucleotide and polypeptide sequences of ACC synthases, namely ACS2, ACS6, and ACS7 from Zea mays, are provided. Knockout plant cells having inhibition in expression and/or activity in an A... | 02/28/2012 |
| 8120777 | Temperature-stable interferometer This invention provides an interferometric detection device configured to maintain a temperature of a sensing area to within 20 m° C. of a first target temperature and to maintain a temperature of the medium within 500 m° C. of a second target temperature The devi... | 02/21/2012 |
| 8114681 | Highly multiplexed particle-based assays Methods are provided for detecting and optionally quantitating multiple analytes, including nucleic acid and/or polypeptide analytes, in particle-based assays that can be highly multiplexed. Compositions, systems, and kits related to the methods are also featured. | 02/14/2012 |
| 8114654 | Site-specific incorporation of redox active amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided.... | 02/14/2012 |
| 8114652 | Genetically programmed expression of selectively sulfated proteins in eubacteria The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited... | 02/14/2012 |
| 8114648 | In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... | 02/14/2012 |
| 8114629 | Site specific incorporation of keto amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods... | 02/14/2012 |
| 8114628 | Expanding the eukaryotic genetic code This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of... | 02/14/2012 |
| 8114627 | Genetically programmed expression of selectively sulfated proteins in eubacteria The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited... | 02/14/2012 |
| 8105288 | Apparatus for peripheral vascular access This invention provides devices and methods for insertion of a catheter into a vessel. The devices include coaxial slidably mounted needle, dilator and catheter components. The methods include piercing a vessel with the needle component, dilating the pierced hole wi... | 01/31/2012 |
| 8095492 | Method and/or system for providing and/or analyzing influence strategies A method and/or system that can be implemented on a computing device or tables or board game or otherwise uses a rule set to evaluate data about a situation and actors in order to provide advice regarding strategies for influencing actors and/or other outputs. ... | 01/10/2012 |
| 8076083 | Screening methods involving the detection of short-lived proteins A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived... | 12/13/2011 |
| 8071344 | Site specific incorporation of keto amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods... | 12/06/2011 |
| 8067017 | Preservation of bioactive materials by freeze dried foam This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes. ... | 11/29/2011 |
| 8058056 | Method and apparatus for integrated cell handling and measurements Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion. ... | 11/15/2011 |
| 8049067 | Organogenic transformation and regeneration This invention provides methods of transforming organogenic plant cells and regenerating plants from transformed cells. ... | 11/01/2011 |
| 8042916 | Micromachined fluid ejector array This invention relates to a micromachined fluid ejector array having a fluid reservoir bounded at one side by an elastic membrane having scalable arrays of orifices arranged between concentric piezoelectric transducers, and at another side by a top cover supported b... | 10/25/2011 |
| 8037903 | Micromachined electrowetting microfluidic valve This invention relates to a systems and methods of controlling the flow of a fluid in a capillary or microfluidic channel. A first pair of electrodes can influence the wetting of a fluid front at a relatively hydrophobic surface in the channel. A second pair of elec... | 10/18/2011 |
| 8030074 | In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... | 10/04/2011 |
| 8030028 | Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are p... | 10/04/2011 |
| 8017360 | Detection of nucleic acids through amplification of surrogate nucleic acids Methods for detecting and optionally quantitating one or more target nucleic acids are provided, in which a surrogate nucleic acid is captured to each target nucleic acid, amplified, and detected. Compositions, kit, and systems related to the methods are also descri... | 09/13/2011 |
| 8013537 | Lighting system power adaptor A power adaptor for a lighting unit, comprising an input for coupling to an electrical power supply and a controller adapted to monitor the input and operable to provide at least two independent electrical outputs; each output having a power level based on an amount... | 09/06/2011 |
| 8012739 | Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are al... | 09/06/2011 |
| 8003330 | Error-free amplification of DNA for clonal sequencing Provided are methods of producing low copy number circularized nucleic acid variants that can be distributed to reaction volumes. The methods include providing a template nucleic acid; producing a population of clonal nucleic acids from the template nucleic acid; ge... | 08/23/2011 |
| 7998487 | Antitoxin and vaccine platform based on nodavirus VLPs Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs a... | 08/16/2011 |
| 7997984 | Method and system of real video gaming Methods and systems for gaming over a network or communications medium such as via the Internet. In specific embodiments, a real video gaming experience is generated by for a player at a client system from a sequence of real world derived chance events and associate... | 08/16/2011 |
| 7981842 | Method for detecting transcription factor-protein interactions A method is provided for identifying complexes between a transcription factor and another protein, such as another different transcription factor. The method includes the steps of isolating from a biological sample transcription factor complexes based on whether the... | 07/19/2011 |
| 7978869 | Wireless microphone A wireless microphone includes a perforated front cover mounted on a front open end of a tubular housing, and a control module mounted fixedly on a rear open end of the housing and having an outer surrounding surface provided with a power switch and electrode plates... | 07/12/2011 |
| 7976646 | Electronic grade metal nanostructures Methods for producing electronic grade metal nanostructures having low levels of contaminants are provided. Monolayer arrays, populations, and devices including such electronic grade nanostructures are described. In addition, novel methods and compositions for produ... | 07/12/2011 |
| 7974429 | Wireless microphone A wireless microphone includes a tubular housing having top and bottom open ends. The housing has an outer surrounding wall and an inner partition wall. The inner partition wall cooperates with an upper portion of the outer surrounding wall so as to define a battery... | 07/05/2011 |
