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| Number | Title | Issue Date |
| 7214712 | Isophthalic acid derivatives as matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C... | 05/08/2007 |
| 7189747 | Method of treating noninflammatory cartilage damage The invention relates to a method of preventing or treating cartilage damage by administering a GABA analog such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R | 03/13/2007 |
| 7179822 | Hetero biaryl derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable... | 02/20/2007 |
| 7160893 | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, R2, R3, and R4 are as defined in the spec... | 01/09/2007 |
| 7132424 | Monocyclic derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I R1-Q-D-(V1)m—R2I or a pharmaceutically acceptable salt thereof, wherein R1, Q, D, V1, m,... | 11/07/2006 |
| 7030119 | Method for treating chronic pain using MEK inhibitors The invention features a method for treating chronic pain using a compound of formula (I). ... | 04/18/2006 |
| 7015237 | Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydrox... | 03/21/2006 |
| 6995151 | Isophthalic acid derivatives as matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1 | 02/07/2006 |
| 6977261 | Azaisoquinoline derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y, R2, R3, R4, R5, and n are as defi... | 12/20/2005 |
| 6974822 | 3-isoquinolinone derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, Q, R2, R3, R4, and n are as defined in the specif... | 12/13/2005 |
| 6962922 | Alkynylated quinazoline compounds A compound selected from those of formula (I): wherein W1 represents O, S, or —NR3 in which R3 represents hydrogen, alkyl, OH or CN; W2 represe... | 11/08/2005 |
| 6949651 | Fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of t... | 09/27/2005 |
| 6943174 | 6,5-Fused bicyclic heterocycles The present invention provides compounds of Formula (I) wherein Q1, Q2, Q3, Q4, Y1, Y2, and Z are as defined in the description, and pharmaceutically acceptable salts thereof, and C1-C... | 09/13/2005 |
| 6942876 | Analgesic compositions comprising anti-epileptic compounds and methods of using same The present invention is directed to novel combinations of anti-epileptic compounds that demonstrate pain alleviating properties, with compounds selected from the group consisting of analgesics, NMDA receptor antagonists, and NSAIDs and pharmaceutical compositions c... | 09/13/2005 |
| 6936616 | Pyrimidine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyrimidine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R2 is hydrogen, halo, hydroxy... | 08/30/2005 |
| 6924276 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors The invention provides dicarboxylic acid-substituted heteroaryl derivatives of the formula G1-(C(R1)R2)n-Q1-B-Q2-(C(R3)R4)m-G2 I or... | 08/02/2005 |
| 6908917 | Chromone derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y2, Y3, Y4, U5, U6, U | 06/21/2005 |
| 6906094 | 1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase The present invention provides compounds of formula (I) wherein R, Z, Y, W, R5, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to the inhibition of the e... | 06/14/2005 |
| 6906092 | Method of inhibiting matrix metalloproteinases The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a m... | 06/14/2005 |
| 6897223 | Pyridine fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of t... | 05/24/2005 |
| 6894057 | Oxo-azabicyclic compounds A compound selected from those of formula (I): wherein: X1, X2, and X3, represent N or —CR3 in which R3 is as described in the... | 05/17/2005 |
| 6887902 | Anti-inflammatory method using gamma-aminobutyric acid (GABA) analogs GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases. ... | 05/03/2005 |
| 6881743 | Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independen... | 04/19/2005 |
| 6875765 | Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized s... | 04/05/2005 |
| 6869958 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y1, Y2, Y3, and R... | 03/22/2005 |
| 6858739 | Indole and benzimidazole 15-lipoxygenase inhibitors This invention provides indole and benzimidazole 15-lipoxygenase (15-LO) inhibitors of the formula where one of Y1 and Y2 is CH, N, or NH, and the other is R3 includes H, halo, HN2, COOH, alkyl; R4 includes halo... | 02/22/2005 |
| 6849648 | Phenylene alkyne matrix metalloproteinase inhibitors A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibi... | 02/01/2005 |
| 6849637 | Triazolo compounds as MMP inhibitors A compound selected from those of formula (I): in which: W represents N or C—R1; in which R1 is as defined in the description, X represents N or C—R2 in wh... | 02/01/2005 |
| 6828326 | Pyrimidinone fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical comp... | 12/07/2004 |
| 6815543 | Process for catalyzing the oxidation of organic compounds Oxidation of organic compounds is catalyzed by addition of a catalytic amount of a metalloporphyrin in a non-reactive aprotic solvent. ... | 11/09/2004 |
| 6794497 | Aminofuranose compounds The present invention provides compounds and methods of synthesizing furanose and aminofuranose compounds of Formula I which are useful fro treating rheumatoid arthritis, immunomodulatory diseases and disorders, inflamma... | 09/21/2004 |
| 6747147 | Oxo-azabicyclic compounds A compound selected from those of formula (I): wherein: X1, X2, and X3, represent N or —CR3 in which R3 is as described in the description, G1 | 06/08/2004 |
| 6645979 | (7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine The invention described herein relates to a process for the preparation of (7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine (I), intermediates thereto and new forms and formulations thereof, including the zwitterion monohydrate of (I), suitable for... | 11/11/2003 |
