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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 8183380 | 2-aminoquinolines The present invention is concerned with 2-aminoquinoline derivatives of formula I where R1, R2, R3, R4, R5, R6, A, and n are as defined in the specification ... | 05/22/2012 |
| 8183262 | Pyridine derivatives as mGluR2 antagonists The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R | 05/22/2012 |
| 8178538 | Pyridazinones The present invention is concerned with novel pyridazinones of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologicall... | 05/15/2012 |
| 8178522 | Thiazoles The present invention is concerned with isoxazole-thiazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The activ... | 05/15/2012 |
| 8173652 | Isoxazole-isoxazoles and isoxazole-isothiazoles The present invention is concerned with isoxazole-isoxazoles and isoxazole-isothiazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for ... | 05/08/2012 |
| 8163740 | 6-substituted benzoxazines The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I) wherein X, Y, R1 and R2 are as described herein, their manufacture, and pharmaceutical compositions containi... | 04/24/2012 |
| 8163728 | Pyrazoles The present invention is concerned with isoxazole-pyrazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutics. The active compounds of the present inven... | 04/24/2012 |
| 8158668 | Methods for treating CNS disorders with 4-imidazole derivatives The present invention relates to methods for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, n... | 04/17/2012 |
| 8153679 | Radiolabelled inhibitors of the glycine 1 transporter The present invention relates to novel radiolabelled inhibitors of formula I for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality. wherein ... | 04/10/2012 |
| 8153653 | Amido-tropane derivatives The present invention relates to a compound of formula I wherein R1, R2 and R3 are each independently hydrogen, lower alkyl, lower alkoxy, cycloalkyl, lower alkyl substituted by... | 04/10/2012 |
| 8143281 | Indoles The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of ... | 03/27/2012 |
| 8143273 | Quinolizidine and indolizidine derivatives The present invention relates to a compound of formula I-A or I-B wherein X, R1, R2 and R3 are defined herein; or to a pharmaceutically acceptable acid add... | 03/27/2012 |
| 8133909 | Heteroaromatic monoamides as orexinin receptor antagonists The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3, R4, R5, Ar, Ar1, Ar2, n, o and p are as described in the... | 03/13/2012 |
| 8097637 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their man... | 01/17/2012 |
| 8093263 | Substituted pyrazolo [1,5-a] pyrimidines as metabotropic glutamate antagonists The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical... | 01/10/2012 |
| 8084609 | Spiropiperidine derivatives The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other diseases. The compoun... | 12/27/2011 |
| 8080541 | Carbocyclic GlyT-1 receptor antagonists The present invention relates to the use of a compound of formula I wherein R1, R2, R3, R4, X and n are as defined herein or to a pharmaceutically acceptable acid additi... | 12/20/2011 |
| 8076360 | Indoles The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are usefu... | 12/13/2011 |
| 8071622 | Indoles The present invention is concerned with novel indol-2-yl-carbonyl-piperidin-benzoimidazolon and indol-2-yl-carbonyl-piperidin-benzoxazolon derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the t... | 12/06/2011 |
| 8067598 | Heterofused piperidines as orexin antagonists The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring s... | 11/29/2011 |
| 8063098 | GlyT1 receptor antagonists The present invention relates to a compound of formula I wherein R1, R2, X, Ar1 and Ar2 are as defined herein and to pharmaceutically acceptable... | 11/22/2011 |
| 8063076 | Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phen... | 11/22/2011 |
| 8063075 | Pyrrolidine ether derivatives as NK3 receptor antagonists The present invention relates to compounds of formula I wherein R1, R2, R3, R′, Ar, m, n, and o are as defined herein. The invention also relates to pharmaceutical compositions containing ... | 11/22/2011 |
| 8063048 | Acetylenyl-pyrazolo-pyrimidine derivatives The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufactu... | 11/22/2011 |
| 8044202 | Azaspiro derivatives The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other... | 10/25/2011 |
| 8044047 | 5-substituted benzoxazines The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I) wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions cont... | 10/25/2011 |
| 8039624 | Azaspiro derivatives The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other... | 10/18/2011 |
| 8039490 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r ... | 10/18/2011 |
| 8039473 | Solid forms of [4-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparatio... | 10/18/2011 |
| 8034937 | Azaspiro derivatives The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other... | 10/11/2011 |
| 8026259 | Indoles The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are usefu... | 09/27/2011 |
| 8022213 | Spiro-piperidine derivatives Present invention is concerned with novel indol-2-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them. The active compounds of the present invention are useful in the treatment of anxie... | 09/20/2011 |
| 8022099 | N-benzyl pyrrolidine derivatives The present invention relates to a compound of formula I wherein Ar, R1, R2, R3, n, and o are as defined herein or to a pharmaceutically active salt, a racemic mixture... | 09/20/2011 |
| 8017604 | Imidazopyridines The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, a... | 09/13/2011 |
| 8012998 | Pyrrolidine aryl-ether as NK-3 receptor antagonists The invention relates to a compound of formula I wherein Ar1, Ar2, R1, R2, R3, R4, n, o, p, and q are as ... | 09/06/2011 |
| 8012986 | Pyridine and pyrimidine derivatives as MGLUR2 antagonists The present invention relates to compounds of formula (I) wherein A, B, Q, X, Y, R1, and R2 are as defined herein; pharmaceutical compositions containing them; a process for their manufacture; and meth... | 09/06/2011 |
| 8008305 | TAAR1 ligands The invention relates to a compound of formula wherein R1, R2, X, L, W, n, and o are defined herein and to pharmaceutically suitable acid addition sa... | 08/30/2011 |
| 7994324 | 2-aminoquinoline derivatives The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I) wherein R1 and R2 are as described herein, pharmaceutical compositions containing such compo... | 08/09/2011 |
| 7989628 | 2-aminoquinolines The present invention is concerned with 2-aminoquinoline derivatives of formula I wherein Z, R1, and Ar1 are as defined herein, pharmaceutical compositions containing them, methods for their manufacture. The compounds are 5... | 08/02/2011 |
| 7989449 | 4,5-dihydro-oxazol-2-yl amine derivatives The present invention relates to a compounds of formula I wherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceuticall... | 08/02/2011 |
