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Attorney: Pope; Lawrence S.


Number of patents: 341
Last date: December 21, 2004

1                  
NumberTitleIssue Date
6833370Heterocycle substituted aminoazacycles useful as central nervous system agents
Heterocyclic substituted aminoazacyclic compounds of formula I Z—R3  I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said comp...
12/21/2004
6166013Glucocortiocoid-selective agents
Compounds having Formula I ##STR1## are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of treating immune, autoimmune, inflammatory, adrenal ...
12/26/2000
61332533-Pyridyl enantiomers and their use as analgesics
The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt t...
10/17/2000
61273863-Pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in con...
10/03/2000
6080874Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydroxyurea
The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[...
06/27/2000
5989827Use of nuclear magnetic resonance to design ligands to target biomolecules
The present invention provides a process of designing compounds which bind to a specific target molecule. The process includes the steps of a) identifying a first ligand to the target molecule using two-dimensional 15 N/1 H NMR corre...
11/23/1999
5863946Iminoxyderivatives of fenamates as inhibitors of prostaglandin biosynthesis
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; X is absent or is alkylene; A is absent or is selected from optionally substituted alkyl...
01/26/1999
5843968Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, ...
12/01/1998
5801119Process for inhibiting stem elongation in bulbous plants and cut flowers therefrom
A process of inhibiting stem elongation in ornamental bulbous plants or in cut flowers from such plants, involving treating such plants or flowers with an effective amount of ACC synthase inhibitor, such as aminoethoxyvinylglycine and aminooxyacetic acid ...
09/01/1998
5691456Reagents and methods for the detection and quantification of thyroxine in fluid samples
Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a lin...
11/25/1997
5679573Stabilized aqueous steroid immunoassay standards with cyclodextrins
Aqueous solutions of steroid compounds which have biological activity and have a tendency to oxidative degradation at temperatures between 2° and 8° C. on storage in excess of several months are stabilized by the addition of cyclodextrin....
10/21/1997
5672480Immunoassays for prostate specific antigen
The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and ଱-antichymotrypsin (ACT) that...
09/30/1997
5670381Devices for performing ion-capture binding assays
This invention presents novel assay devices employing capture reagents, involving a specific binding member attached to a charged substance, and porous material containing a capture or reaction zone that is oppositely charged with respect to the charged s...
09/23/1997
5599677Immunoassays for prostate specific antigen
The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and ଱-antichymotrypsin (ACT) that...
02/04/1997
5516647Compounds useful as alkaline phosphatase inhibitors and therapeutic agents
The present invention discloses novel compounds useful as alkaline phosphatase inhibitors and therapeutic agents. Preferably, the novel compounds are useful as selective inhibitors of human alkaline phosphatases as opposed to Escherichia coli alkaline pho...
05/14/1996
5496716Stabilized creative kinase MB composition
A stabilized liquid enzyme composition is prepared containing at least one enzyme substrate or analog thereof and/or at least one enzyme product or analog thereof combined with the enzyme in a liquid medium containing. The liquid medium may be human, anim...
03/05/1996
5411894Method of using tissue and cell adhesive preparations for biological test systems
The present invention includes adhesive solutions, devices and a method for the preparation of histological, cytological, immunological and proteinaceous samples for evaluation. The devices involve at least one sample deposition area formed from an adhesi...
05/02/1995
5407834Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically,...
04/18/1995
5392209Method and apparatus for providing a data interface between a plurality of test information sources and a database
A data interface which is capable of receiving test information from a variety of biological fluid testing instruments employs first and second processes. The first process determines the type of data which is provided by analyzing the format of the test ...
02/21/1995
5356772Process for preparing an improved western blot immunoassay
The present invention encompasses an improved immunoassay method which involves the simultaneous transfer of multiple antigens onto a single solid support. The antigens which may be utilized by this method may be either naturally or recombinantly produced...
10/18/1994
5320808Reaction cartridge and carousel for biological sample analyzer
A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for human IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples....
06/14/1994
5311426Apparatus and method for providing assay calibration data
A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for human IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples....
05/10/1994
5283344Coupling method using selective amination of maleimide
The instant invention is a method of coupling compounds comprising the steps of: a) forming a maleimide derivative by reacting a maleimide containing compound having the formula: ##STR1## with an amine functional compound capable of displacing the ...
02/01/1994
4698362Low viscosity oil based pesticide compositions
The present disclosure is concerned with a technique for producing storage stable, non-caking, low viscosity pesticidal concentrates and the compositions so obtained. The technique involves milling a solid biologically active compound in a low viscosity a...
10/06/1987
4690947Synergistic composition for the control of arthropods
Arthropodicidal compositions in the form of synergistic combinations of (A) cyano-(4-fluoro-3-phenoxyphenyl)-methyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate plus (B) O-ethyl-O-[4-(methylthio)-phenyl]-S-propyl phosphorodithioate, (A) plus...
09/01/1987
4676234Moisture-hardenable bandaging materials
The invention relates to a self-hardening material for supporting bandages which is packaged with exclusion of moisture and consists of an air-permeable, flexible carrier material which is impregnated and/or coated with a compound possessing at least 2 NC...
06/30/1987
4673410Anionic dye dispersions with enhanced cold water solubility upon dilution
The present disclosure is concerned with enhancing the solubility of dispersed anionic dyes upon the dilution of their dispersions with room temperature water. Concentrated dispersions of such dyes with acceptable stability and low shear viscosities are d...
06/16/1987
4661099Self-adhesive sheet-like structures, process for their preparation and their use
The present disclosure is concerned with self-adhesive sheet-like structures made by adhering an adhesive polyurethane gel material to a supporting substrate and the utilization of such structures in the medical field to adhere materials such as plasters,...
04/28/1987
4621940Stiff but bendable elongated plastic article
The present application is concerned with an elongated stiff but bendable plastic article which finds particular utility in highway delineators. The article has a central lens shape in the cross-section perpendicular to its longitudinal axis which is form...
11/11/1986
4581397Stabilized polycarbonate composition
A molding composition comprising a polycarbonate resin and an impact modifier containing an acrylate or a methacrylate functionality is imparted improved processability and freedom from splay upon the admixing of a certain stabilizer therewith....
04/08/1986
4578409Flame retarding silanes
The present invention relates to a novel halogenated silane conforming to the structure ##STR1## where X is a halogen atom, n is an integer of from 1 to 4, p is an integer of from 1 to 9 and m is an integer of from 1 to 5. The silane thus disclo...
03/25/1986
4576649Color enhanced permanent pigments from precipitated cationic dyes
The present disclosure is concerned with the preparation of permanent pigments from selected cationic dyes by precipitation from aqueous solution with complex heteropoly acids in the presence of selected amine color enhancing agents. Typical of the dyes i...
03/18/1986
4570622Constructional material
The present invention relates to a constructional material which is stable in storage and which is kept under moisture-free conditions and which comprises a substrate and a reactive one-component system which hardens on exposure to air by reaction with mo...
02/18/1986
4567210Process for foaming thermoplastic aromatic polycarbonates
The present invention relates to a process for foaming thermoplastic aromatic polycarbonates, 2-phenyl-1-oxa-3,4-diazol-5-ones acylated in the 4-position being used in combination with cyanuric acid....
01/28/1986
4563503Polycarbonate compositions having improved impact performance
A thermoplastic compositions comprising an aromatic polycarbonate resin and a copolymer of C1 -C18 alkyl acrylate with a hydroxy C1 -C18 alkylacrylate is characterized by its improved notched Izod impact strengt...
01/07/1986
4563516Polyether-polycarbonates for dialysis membranes
The present invention relates to a process for the preparation of polyether-polycarbonates, a process for stabilizing the polyether-polycarbonates thus prepared, a process for the production of membranes from the polyether-polycarbonates prepared accordin...
01/07/1986
45581624,4'-Bis(4-hydroxyphenyl thio)biphenyls
The present invention relates to the novel monomer 4,4'-bis(4-hydroxyphenyl thio)biphenyl, to a process for its production and to its use in the preparation of polycarbonates, polyurethanes, polyesters, polysulfones and polyethers....
12/10/1985
4554314Thermoplastic molding compositions
The present invention is directed to thermoplastic molding compositions comprising a blend of poly(alkylene terephthalate) and polycarbonate resins characterized in that the weight ratio between said resins is about 1:1 to 4:1 and in that a graft modified...
11/19/1985
4552911Polycarbonate molding compositions having improved flame retardance
The present invention relates to polycarbonate molding compositions containing additives of alkali or alkaline earth metal salts, tetrahalogenophthalimides and optional glass fibers, characterized in that they contain additive amounts of bromine....
11/12/1985
4549980White modification of a bis-triazinyl amino stilbene optical brightener and a process for making the same
The present invention is concerned with the modification of the sodium salt of a known optical brightener to obtain a white crystalline material. The commercially available 4,4'-bis-(2-anilino-4-phenylamino-1,3,5-triazinyl-6-amino)-stilbene-2,2'-d isu...
10/29/1985
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