"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 6833370 | Heterocycle substituted aminoazacycles useful as central nervous system agents Heterocyclic substituted aminoazacyclic compounds of formula I Z—R3 I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said comp... | 12/21/2004 |
| 6166013 | Glucocortiocoid-selective agents Compounds having Formula I ##STR1## are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of treating immune, autoimmune, inflammatory, adrenal ... | 12/26/2000 |
| 6133253 | 3-Pyridyl enantiomers and their use as analgesics The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt t... | 10/17/2000 |
| 6127386 | 3-Pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in con... | 10/03/2000 |
| 6080874 | Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydroxyurea The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[... | 06/27/2000 |
| 5989827 | Use of nuclear magnetic resonance to design ligands to target biomolecules The present invention provides a process of designing compounds which bind to a specific target molecule. The process includes the steps of a) identifying a first ligand to the target molecule using two-dimensional 15 N/1 H NMR corre... | 11/23/1999 |
| 5863946 | Iminoxyderivatives of fenamates as inhibitors of prostaglandin biosynthesis Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; X is absent or is alkylene; A is absent or is selected from optionally substituted alkyl... | 01/26/1999 |
| 5843968 | Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, ... | 12/01/1998 |
| 5801119 | Process for inhibiting stem elongation in bulbous plants and cut flowers therefrom A process of inhibiting stem elongation in ornamental bulbous plants or in cut flowers from such plants, involving treating such plants or flowers with an effective amount of ACC synthase inhibitor, such as aminoethoxyvinylglycine and aminooxyacetic acid ... | 09/01/1998 |
| 5691456 | Reagents and methods for the detection and quantification of thyroxine in fluid samples Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a lin... | 11/25/1997 |
| 5679573 | Stabilized aqueous steroid immunoassay standards with cyclodextrins Aqueous solutions of steroid compounds which have biological activity and have a tendency to oxidative degradation at temperatures between 2° and 8° C. on storage in excess of several months are stabilized by the addition of cyclodextrin.... | 10/21/1997 |
| 5672480 | Immunoassays for prostate specific antigen The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and -antichymotrypsin (ACT) that... | 09/30/1997 |
| 5670381 | Devices for performing ion-capture binding assays This invention presents novel assay devices employing capture reagents, involving a specific binding member attached to a charged substance, and porous material containing a capture or reaction zone that is oppositely charged with respect to the charged s... | 09/23/1997 |
| 5599677 | Immunoassays for prostate specific antigen The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and -antichymotrypsin (ACT) that... | 02/04/1997 |
| 5516647 | Compounds useful as alkaline phosphatase inhibitors and therapeutic agents The present invention discloses novel compounds useful as alkaline phosphatase inhibitors and therapeutic agents. Preferably, the novel compounds are useful as selective inhibitors of human alkaline phosphatases as opposed to Escherichia coli alkaline pho... | 05/14/1996 |
| 5496716 | Stabilized creative kinase MB composition A stabilized liquid enzyme composition is prepared containing at least one enzyme substrate or analog thereof and/or at least one enzyme product or analog thereof combined with the enzyme in a liquid medium containing. The liquid medium may be human, anim... | 03/05/1996 |
| 5411894 | Method of using tissue and cell adhesive preparations for biological test systems The present invention includes adhesive solutions, devices and a method for the preparation of histological, cytological, immunological and proteinaceous samples for evaluation. The devices involve at least one sample deposition area formed from an adhesi... | 05/02/1995 |
| 5407834 | Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically,... | 04/18/1995 |
| 5392209 | Method and apparatus for providing a data interface between a plurality of test information sources and a database A data interface which is capable of receiving test information from a variety of biological fluid testing instruments employs first and second processes. The first process determines the type of data which is provided by analyzing the format of the test ... | 02/21/1995 |
| 5356772 | Process for preparing an improved western blot immunoassay The present invention encompasses an improved immunoassay method which involves the simultaneous transfer of multiple antigens onto a single solid support. The antigens which may be utilized by this method may be either naturally or recombinantly produced... | 10/18/1994 |
| 5320808 | Reaction cartridge and carousel for biological sample analyzer A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for human IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples.... | 06/14/1994 |
| 5311426 | Apparatus and method for providing assay calibration data A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for human IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples.... | 05/10/1994 |
| 5283344 | Coupling method using selective amination of maleimide The instant invention is a method of coupling compounds comprising the steps of: a) forming a maleimide derivative by reacting a maleimide containing compound having the formula: ##STR1## with an amine functional compound capable of displacing the ... | 02/01/1994 |
| 4698362 | Low viscosity oil based pesticide compositions The present disclosure is concerned with a technique for producing storage stable, non-caking, low viscosity pesticidal concentrates and the compositions so obtained. The technique involves milling a solid biologically active compound in a low viscosity a... | 10/06/1987 |
| 4690947 | Synergistic composition for the control of arthropods Arthropodicidal compositions in the form of synergistic combinations of (A) cyano-(4-fluoro-3-phenoxyphenyl)-methyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate plus (B) O-ethyl-O-[4-(methylthio)-phenyl]-S-propyl phosphorodithioate, (A) plus... | 09/01/1987 |
| 4676234 | Moisture-hardenable bandaging materials The invention relates to a self-hardening material for supporting bandages which is packaged with exclusion of moisture and consists of an air-permeable, flexible carrier material which is impregnated and/or coated with a compound possessing at least 2 NC... | 06/30/1987 |
| 4673410 | Anionic dye dispersions with enhanced cold water solubility upon dilution The present disclosure is concerned with enhancing the solubility of dispersed anionic dyes upon the dilution of their dispersions with room temperature water. Concentrated dispersions of such dyes with acceptable stability and low shear viscosities are d... | 06/16/1987 |
| 4661099 | Self-adhesive sheet-like structures, process for their preparation and their use The present disclosure is concerned with self-adhesive sheet-like structures made by adhering an adhesive polyurethane gel material to a supporting substrate and the utilization of such structures in the medical field to adhere materials such as plasters,... | 04/28/1987 |
| 4621940 | Stiff but bendable elongated plastic article The present application is concerned with an elongated stiff but bendable plastic article which finds particular utility in highway delineators. The article has a central lens shape in the cross-section perpendicular to its longitudinal axis which is form... | 11/11/1986 |
| 4581397 | Stabilized polycarbonate composition A molding composition comprising a polycarbonate resin and an impact modifier containing an acrylate or a methacrylate functionality is imparted improved processability and freedom from splay upon the admixing of a certain stabilizer therewith.... | 04/08/1986 |
| 4578409 | Flame retarding silanes The present invention relates to a novel halogenated silane conforming to the structure ##STR1## where X is a halogen atom, n is an integer of from 1 to 4, p is an integer of from 1 to 9 and m is an integer of from 1 to 5. The silane thus disclo... | 03/25/1986 |
| 4576649 | Color enhanced permanent pigments from precipitated cationic dyes The present disclosure is concerned with the preparation of permanent pigments from selected cationic dyes by precipitation from aqueous solution with complex heteropoly acids in the presence of selected amine color enhancing agents. Typical of the dyes i... | 03/18/1986 |
| 4570622 | Constructional material The present invention relates to a constructional material which is stable in storage and which is kept under moisture-free conditions and which comprises a substrate and a reactive one-component system which hardens on exposure to air by reaction with mo... | 02/18/1986 |
| 4567210 | Process for foaming thermoplastic aromatic polycarbonates The present invention relates to a process for foaming thermoplastic aromatic polycarbonates, 2-phenyl-1-oxa-3,4-diazol-5-ones acylated in the 4-position being used in combination with cyanuric acid.... | 01/28/1986 |
| 4563503 | Polycarbonate compositions having improved impact performance A thermoplastic compositions comprising an aromatic polycarbonate resin and a copolymer of C1 -C18 alkyl acrylate with a hydroxy C1 -C18 alkylacrylate is characterized by its improved notched Izod impact strengt... | 01/07/1986 |
| 4563516 | Polyether-polycarbonates for dialysis membranes The present invention relates to a process for the preparation of polyether-polycarbonates, a process for stabilizing the polyether-polycarbonates thus prepared, a process for the production of membranes from the polyether-polycarbonates prepared accordin... | 01/07/1986 |
| 4558162 | 4,4'-Bis(4-hydroxyphenyl thio)biphenyls The present invention relates to the novel monomer 4,4'-bis(4-hydroxyphenyl thio)biphenyl, to a process for its production and to its use in the preparation of polycarbonates, polyurethanes, polyesters, polysulfones and polyethers.... | 12/10/1985 |
| 4554314 | Thermoplastic molding compositions The present invention is directed to thermoplastic molding compositions comprising a blend of poly(alkylene terephthalate) and polycarbonate resins characterized in that the weight ratio between said resins is about 1:1 to 4:1 and in that a graft modified... | 11/19/1985 |
| 4552911 | Polycarbonate molding compositions having improved flame retardance The present invention relates to polycarbonate molding compositions containing additives of alkali or alkaline earth metal salts, tetrahalogenophthalimides and optional glass fibers, characterized in that they contain additive amounts of bromine.... | 11/12/1985 |
| 4549980 | White modification of a bis-triazinyl amino stilbene optical brightener and a process for making the same The present invention is concerned with the modification of the sodium salt of a known optical brightener to obtain a white crystalline material. The commercially available 4,4'-bis-(2-anilino-4-phenylamino-1,3,5-triazinyl-6-amino)-stilbene-2,2'-d isu... | 10/29/1985 |