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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7767850 | S-[2-[(1-iminoethy)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly pack... | 08/03/2010 |
| 7713989 | Glucocorticoid receptor modulators The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions cont... | 05/11/2010 |
| 7649004 | Pyridine derivatives The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such c... | 01/19/2010 |
| 7598231 | Tricyclic compound, compositions, and methods The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated ... | 10/06/2009 |
| 7449467 | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokin... | 11/11/2008 |
| 7420061 | Process for preparing prodrugs of benzenesulfonamide-containing COX-2 inhibitors Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders. ... | 09/02/2008 |
| 7323462 | Morpholine dopamine agonists Compounds of formula (I), (Ia) and (Ib) useful as a medicament. ... | 01/29/2008 |
| 7317011 | Method of treating peripheral neuropathy Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine, or a pharmaceutically acceptable salt thereof. Embodiments of these ... | 01/08/2008 |
| 7294691 | Soluble secreted α2δ-2calcium channel subunit polypeptide The present invention relates to secreted soluble α2δ-2, α2δ-3 or α2δ-4 calcium channel subunit polypeptides and their preparation, corresponding nucleic acids, recombinant vectors and host cells, as well as screening assays using same. ... | 11/13/2007 |
| 7288662 | Process for the preparation of eletriptan The present invention provides an improved process for the preparation of the anti-migraine drug, (R)-5-(2-benzenesulphonylethyl)-3-N-methylpyrrolidin-2-ylmethyl)-1H-indole (eletriptan), available commercially as the hydrobromide salt, and an intermediate and dimer-... | 10/30/2007 |
| 7262052 | α-2/δ gene The present invention relates to three novel genes and polypeptides derived therefrom encoding “α2δ-C” and/or “α2δ-D” proteins which exist as a subunit in many calcium channels. The invention also describes methods for using the novel gene and polypeptid... | 08/28/2007 |
| 7255860 | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody. ... | 08/14/2007 |
| 7252822 | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist The invention features methods and compositions for preventing or treating pain resulting from surgery or an incision by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of b... | 08/07/2007 |
| 7238676 | Purine derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and composition... | 07/03/2007 |
| 7238714 | Aryl or heteroaryl amide compounds This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R1 and R2 indepe... | 07/03/2007 |
| 7235363 | Method for the screening of αδ-1 subunit binding ligands A method for the screening of ligands which bind to soluble α2δ-1 subtype polypeptides. ... | 06/26/2007 |
| 7232816 | Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them The invention relates to novel substituted pyrazolo[4,3-e]-diazepines of general formula: to pharmaceutical compositions containing them, to their use as medicinal products and to processes for preparing them. | 06/19/2007 |
| 7186743 | Substituted pyrazolyl compounds for the treatment of inflammation The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthri... | 03/06/2007 |
| 7132441 | Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor This invention is in the field of a combination comprising a therapeutically-effective amount of a cyclooxygenase-2 inhibitor, a 5-lipoxygenase inhibitor and an immunosuppressive drug selected from antiproliferative agents, antiinflammatory-acting compounds and inhi... | 11/07/2006 |
| 7132435 | Compounds This invention relates to nicotinamide derivatives of general formula (I): in which R1, X, Y, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediate... | 11/07/2006 |
| 7107985 | Pharmaceutical combination The present invention relates to a combination comprising (a) an adenosine A2a receptor agonist as define herein and (b) an adrenergic β2 receptor agonist, for simultaneous, sequential or separate administration by the inhaled route in the treatment of a... | 09/19/2006 |
| 7012098 | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase and an inhibitor of cylcooxyg... | 03/14/2006 |
| 7005450 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 02/28/2006 |
| 6998415 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. ... | 02/14/2006 |
| 6998503 | Crystalline solid form of (2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid (2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid is crystallized as an anhydrous, stoichiometric 1.5 HCl salt and a scaleable crystallization method is disclosed. The salt form was characterized and the absolute configuration of the chiral center was ... | 02/14/2006 |
| 6995281 | Methods for selectively removing counterions from compounds and compounds derived from such methods Methods of selectively removing counterions from compounds are disclosed. Compounds derived from the methods, such as the compound S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine zwitterion with between zero and up to 2 molar equivalents of hydrochloride are al... | 02/07/2006 |
| 6956131 | 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R2 is selected from the group consisting of H and methyl; and R... | 10/18/2005 |
| 6951889 | 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 10/04/2005 |
| 6914158 | Amidino compounds useful as nitric oxide synthase inhibitors The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the prese... | 07/05/2005 |
| 6828456 | 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 12/07/2004 |
| 6774126 | Pyrrolo[1,2-b][1,2,4]oxadiazine diones useful as nitric oxide synthase inhibitors Pyrrolo[1,2-b][1,2,4]oxadiazine-2,3(6H)-diones having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein. ... | 08/10/2004 |
| 6716844 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl aipha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid compound in an MM... | 04/06/2004 |
| 6716829 | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders Combinations of aldosterone blockers and Cyclooxygenase-2 inhibitors useful in the treatment of inflammation are disclosed. ... | 04/06/2004 |
| 6653350 | Methods of treating osteoarthritis with inducible nitric oxide synthase inhibitors Methods of treating osteoarthritis by administering an therapeutically effective amount of NOS inhibitor are provided.... | 11/25/2003 |
| 6638952 | Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds An aromatic sulfonyl alpha-cycloamino hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-cycloamino hydroxamic acid ... | 10/28/2003 |
| 6638758 | Process for the enzymatic resolution of lactams A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the cor... | 10/28/2003 |
| 6586471 | Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.... | 07/01/2003 |
| 6576780 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 06/10/2003 |
| 6552052 | Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: ##STR1## or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.... | 04/22/2003 |
| 6545170 | 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention contains novel compounds useful as nitric oxide synthase inhibitors.... | 04/08/2003 |
