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Vehicular Impact Signaling Device
An apparatus for the deployment of a visible plume to alert other motorists that a proximate motor vehicle has been involved in a collision.
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| Number | Title | Issue Date |
| 8173394 | Systems and methods for protein production The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-enginee... | 05/08/2012 |
| 8168397 | Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of cell signalling molecules are conjugated to suitable carrier proteins a... | 05/01/2012 |
| 8129504 | Oral delivery of modified transferrin fusion proteins Pharmaceutical compositions containing modified fusion proteins of transferrin and therapeutic proteins or peptides with increased serum half-life or increased serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin mo... | 03/06/2012 |
| 8129145 | Production of glycoproteins An improved system for large scale production of glycoproteins in cell culture is provided. In accordance with the present invention, cells expressing a glycoprotein are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM.... | 03/06/2012 |
| 8080243 | Isolated antibody which specifically binds to PCSK9 The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The i... | 12/20/2011 |
| 8034346 | Methods for treating pain by administering a nerve growth factor antagonist and an NSAID and compositions containing the same The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The inventio... | 10/11/2011 |
| 7183294 | Indole derivatives useful for the treatment of diseases The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous... | 02/27/2007 |
| 7138527 | Indole derivatives useful for the treatment of diseases The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous... | 11/21/2006 |
| 6977261 | Azaisoquinoline derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y, R2, R3, R4, R5, and n are as defi... | 12/20/2005 |
| 6974822 | 3-isoquinolinone derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, Q, R2, R3, R4, and n are as defined in the specif... | 12/13/2005 |
| 6949651 | Fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of t... | 09/27/2005 |
| 6924276 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors The invention provides dicarboxylic acid-substituted heteroaryl derivatives of the formula G1-(C(R1)R2)n-Q1-B-Q2-(C(R3)R4)m-G2 I or... | 08/02/2005 |
| 6906092 | Method of inhibiting matrix metalloproteinases The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a m... | 06/14/2005 |
| 6897223 | Pyridine fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of t... | 05/24/2005 |
| 6894057 | Oxo-azabicyclic compounds A compound selected from those of formula (I): wherein: X1, X2, and X3, represent N or —CR3 in which R3 is as described in the... | 05/17/2005 |
| 6881743 | Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independen... | 04/19/2005 |
| 6869958 | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y1, Y2, Y3, and R... | 03/22/2005 |
| 6861555 | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula (I), wherein R1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia. | 03/01/2005 |
| 6849648 | Phenylene alkyne matrix metalloproteinase inhibitors A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibi... | 02/01/2005 |
| 6828326 | Pyrimidinone fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical comp... | 12/07/2004 |
| 6794497 | Aminofuranose compounds The present invention provides compounds and methods of synthesizing furanose and aminofuranose compounds of Formula I which are useful fro treating rheumatoid arthritis, immunomodulatory diseases and disorders, inflamma... | 09/21/2004 |
| 6747147 | Oxo-azabicyclic compounds A compound selected from those of formula (I): wherein: X1, X2, and X3, represent N or —CR3 in which R3 is as described in the description, G1 | 06/08/2004 |
