Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 6852729 | Macrolides A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation. | 02/08/2005 |
| 6693095 | Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates A compound of formula ##STR1## wherein W, V, R1, R5, R2, R3 and R4 have various meanings, a process for their production and their use as a pharmaceutical.... | 02/17/2004 |
| 6693211 | Chemical process This invention provides a process for preparing sodium ferric gluconate complex in sucrose using the following steps: a) combining a ferric salt solution with a weak alkali chosen from the group consisting of alkaline earth metal and ammonium salts, such a... | 02/17/2004 |
| 6599886 | Macrolide intermediates in the preparation of clarithromycin The present invention relates to a process for the production of clarithromycin from an aqueous medium in anhydrous form and in the form of a hydrate.... | 07/29/2003 |
| 6566580 | Neurological disease model The use of a metabotropic glutamate receptor mGluR7 agonist for the facilitation of neurotransmitter release from a nerve ending and the treatment of neurological conditions, including epilepsy. Transgenic knockout non-human mammals are provided which lac... | 05/20/2003 |
| 6552186 | ଲ-lactam production ##STR1## The present invention provides processes for the production of a compound of formula I wherein X, R1 and R2 are substituents conventional in cephalosporin chemistry; especially a compound of formula I is ceftrixone, cefotaxime; e.g., in the form ... | 04/22/2003 |
| 6504017 | Erthromycin a oxime solvates Erythromycin A oxime in the form of a hemihydrate.... | 01/07/2003 |
| 6498034 | Method of producing dendritic cells The present invention relates to a method for producing dendritic cells from human hematopoietic progenitor cells by obtaining a cell sample that includes human progenitor cells and culturing the cell sample under plasma-free and serum-free conditions in ... | 12/24/2002 |
| 6489470 | Process for the preparation of cefpodoxime proxetil diastereoisomers A process for increasing the diastereoisomeric ratio (B/A+B), wherein B is the more apolar and A is the more polar of two diastereoisomers, of a mixture of diastereoisomers of a compound of formula ##STR1## the diastereoisomers being with respect to the c... | 12/03/2002 |
| 6465233 | Nucleic acid molecule encoding a cephalosporin acetylesterase The present invention relates to a nucleic acid molecule which codes for the cephalosporin acetylesterase from Bacillus subtilis ATCC 6633 (DSM 11909), vectors and host cells which comprise such a nucleic acid molecule, a process for the recombinant prepa... | 10/15/2002 |
| 6440462 | Agglomerates of ଲ-lactam antibiotics and processess for making agglomerates Agglomerates of ଲ-lactam antibiotics, such as penicilllin V potassium, amoxicillin trihydrate, cephalexin monohydrate, which are suitable for direct tablet formation.... | 08/27/2002 |
| 6440957 | Cephalosporines having cyclic aminoguanidine substituents as antibiotics A compound useful as an anti-bacterial agent, having the formula ##STR1## wherein R2 together with the nitrogen atom to which it is attached forms a cyclic aminoguanidine group or derivative thereof as defined ##STR2## ##STR3##... | 08/27/2002 |
| 6436901 | Pharmaceutical compositions The present invention provides a freeze dried pharmaceutical composition comprising hirudin, potassium phosphate and a sugar.... | 08/20/2002 |
| 6420537 | Macrolide production A process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent in non-halogenated solvent... | 07/16/2002 |
| 6414140 | Process for the production of 3-vinyl cephalosporins A process for the production of a 3-vinylcephalosporin compound of formula I ##STR1## wherein R1 and R2 denote hydrogen or an organic group by a Wittig reaction reacting first a compound of formula II ##STR2## with a compound of... | 07/02/2002 |
| 6406908 | Vanilloid receptor The isolated nucleic acid encoding human vanilloid receptor, said receptor, its preparation, cells expressing said receptor and an assay for testing compounds for their potential to decrease pain in human are disclosed. The receptor is involved in detecti... | 06/18/2002 |
| 6353030 | Relating to organic compounds A polylactide in a purified state, which meets the requirements of the color strengths of reference solutions B2 -B9 of the brown color test of the European Pharmacopoeia, 2nd Edition (1980) part I, Section V, 6.2 and containing one or mo... | 03/05/2002 |
| 6339150 | Mutant rex genes encoding transdominant repressors of HIV/HTLV replication Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex functio... | 01/15/2002 |
| 6300519 | Antivirally active heterocyclic azahexane derivatives There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or more ... | 10/09/2001 |
| 6294656 | Transforming growth factor ଲ crystals The invention concerns TGF-ଲ in a crystalline form which shows no adsorption or less adsorption to the walls of vials than the soluted TGF-ଲ and which is more stable towards oxidative agents than the soluted form. TGF-ଲ crystals of the i... | 09/25/2001 |
| 6291668 | Oligonucleotide derivatives The present invention relates to an oligonucleotide derivative which is specifically hybridizable to a region of a RNA deriving from the gene encoding human Bcl-2 protein, the region being selected from the group consisting of a region comprising a sequen... | 09/18/2001 |
| 6281244 | Therapeutic use for glycine Glycine is indicated to prevent or treat acute or chronic graft rejection, optionally in combination with an immunosuppressant or an immunomodulating agent.... | 08/28/2001 |
| 6258776 | Calcium-regulated kinase The invention concerns a method of modulating the activity of a polypeptide comprising the activating domain of an Ndr family kinase, by influencing the binding of an EF hand-containing calcium binding.... | 07/10/2001 |
| 6232118 | Protein induced by deprenyl We have found that Deprenyl.RTM. induces a novel polypeptide in neural cells. This polypeptide has the structure given in SEQ ID No. 1 and is referred to herein as DIP 1 (Deprenyl.RTM. Induced Protein 1).... | 05/15/2001 |
| 6210700 | Enhancement of transplant graft survival through nutritional immunomodulation with omega-9 fatty acid dietary supplement therapy An improved immunomodulatory therapy for enhancement of depressed host defense mechanisms and improving allograft survival rates comprising the use of omega-9 unsaturated fatty acids to alter the immune response associated with organ transplantation. It i... | 04/03/2001 |
| 6175016 | Pyridine derivatives The invention relates to a process for producing pyridinoline and deoxypyridinoline crosslinks and derivatives thereof and their use in determining connective tissue disorders in humans and animals.... | 01/16/2001 |
| 6166004 | Combinations of HIV protease inhibitors with reverse transcriptase inhibitors There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or ... | 12/26/2000 |
| 6123916 | Therapeutic use of somatostatin peptides The invention relates to a new pharmaceutical use of somatostatin peptides comprising on the terminal amino group a polyamino polycarboxylic group, in free form or in a pharmaceutically acceptable salt form, particularly in the manufacture of a medicament... | 09/26/2000 |
| 6124493 | Process for the preparation of o-chloromethyl-phenylglyoxylic acid derivatives There is described a process for the preparation of a compound of formula I ##STR1## in which process: a) a compound of formula II ##STR2## is reacted with an organolithium compound of formula III Li--R7 ... | 09/26/2000 |
| 6110946 | Antivirally active heterocyclic azahexane derivatives There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted or substituted by one or ... | 08/29/2000 |
| 6066616 | Somatostatin analogue composition and use in treating breast cancer The invention provides a pharmaceutical composition comprising a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better to... | 05/23/2000 |
| 6057430 | Process for the production biologically active dimeric protein The present invention relates to a folding process for the preparation of biologically active, dimeric TGF-ଲ (Tranforming Growth Factor type ଲ)-like protein.... | 05/02/2000 |
| 5998306 | Methods of finishing textile materials The compounds of the s-triazine series of formula I ##STR1## wherein the symbols R1, R2, R3, X and n possess the significances given in claim 1, are eminently suitable, when applied to textile material, as UV-absorber... | 12/07/1999 |
| 5998197 | Fungi for pitch reduction and their preparation Ascospores of wood-penetrating, pitch-grading fungi of the class of Ascomycotina and Deuteromycotina, eg. Ophiostromas, may be screened to provide fungi combining the properties of good growth on non-sterile wood substrates and minimized or even enhanced ... | 12/07/1999 |
| 5972698 | Tryptase inhibitor The present invention relates to novel inhibitors of human tryptase, to their isolation from leeches, to nucleotide sequences encoding the novel inhibtor molecules or fragments thereof, to vectors containing the coding sequence thereof, to host cells tran... | 10/26/1999 |
| 5942010 | Dyeing process and auxiliary Dyeing of cellulosic substrates with reactive dyes in the presence of at least 20 g/l of sodium chloride, employing auxiliaries (E) of levelling activity, which are methylene-bridge-containing and sulpho-group-containing aromatic compounds, obtainable by ... | 08/24/1999 |
| 5939531 | Recombinant antibodies specific for a growth factor receptor The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies dire... | 08/17/1999 |
| 5929102 | Synergistic combination of microbicides to combat fungi on plants A plant-microbicidal composition having synergistic action, comprising at least two active ingredient components, wherein component I is a compound selected from the group (IA) 1-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-ylmethyl!-1H-1,2,4-triazo ... | 07/27/1999 |
| 5922846 | Process for refolding recombinantly produced TGF-ଲ-like proteins The invention relates to a process for the production of biologically active, dimeric TGF-ଲ, to novel TGF-ଲs and pharmaceutical compositions comprising it. TGF-ଲ produced by this process can be used in various therapeutic modalities.... | 07/13/1999 |
| 5922338 | Polyol esters, their preparation and use in depot forms of pharmacologically active agents This invention provides a polyester of a polyol, said polyol containing at least 3 hydroxyl groups and having a molecular weight of up to 20,000 at least 1 hydroxyl group in said polyol being in the form of an ester, with a poly- or co-poly-lactic acid re... | 07/13/1999 |
