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| Number | Title | Issue Date |
| 7426442 | Software for the display of chromatographic separation data Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that is a series of measurements for a sample at a scanning location over time can be displayed on a display device in a series of bands. Ad... | 09/16/2008 |
| 7351377 | Methods and devices for enhancing bonded substrate yields and regulating temperature Methods and devices that include the use of venting elements for enhancing bonded substrate yields and regulating temperature. Venting elements are generally fabricated proximal to functionalized regions in substrate surfaces to prevent bond voids that form during b... | 04/01/2008 |
| 7343248 | Distributed database for analytical instruments Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequential... | 03/11/2008 |
| 7316801 | High throughput microfluidic systems and methods The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having... | 01/08/2008 |
| 7303862 | Microfabrication methods and devices Microfabrication methods and devices in which microscale structural elements are provided in an intermediate polymer layer between two planar substrates. Preferred aspects utilize photoimagable or ablatable polymer layers as the intermediate polymer layer. ... | 12/04/2007 |
| 7303727 | Microfluidic sample delivery devices, systems, and methods Methods and apparatus for delivering fluidic materials to sample destinations, including mass spectrometers for analysis are provided. In preferred embodiments, sample aliquots are electrosprayed from tapered spray tips of capillary elements into the orifices of mas... | 12/04/2007 |
| 7285411 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effe... | 10/23/2007 |
| 7252928 | Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid wi... | 08/07/2007 |
| 7247274 | Prevention of precipitate blockage in microfluidic channels The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular the devices and methods of the invention utilize microchannels of specific cross-sectional con... | 07/24/2007 |
| 7238323 | Microfluidic sequencing systems Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and me... | 07/03/2007 |
| 7208320 | Open-field serial to parallel converter Microfluidic devices and systems for affecting the serial to parallel conversion of materials introduced into the device or system. Material or materials to be converted from a serial orientation, e.g., a single channel, into a parallel orientation, e.g., multiple c... | 04/24/2007 |
| 7195986 | Microfluidic device with controlled substrate conductivity A method to achieve controlled conductivity in microfluidic devices, and a device formed thereby. The method comprises forming a microchannel or a well in an insulating material, and ion implanting at least one region of the insulating material at or adjacent the mi... | 03/27/2007 |
| 7192559 | Methods and devices for high throughput fluid delivery Methods and devices for delivering fluids into microfluidic device body structures are described. The methods and devices include the use of fluid manifolds which are integrated or interchangeable with device body structures. Methods of fabricating manifolds are als... | 03/20/2007 |
| 7171983 | Multi-reservoir pressure control system Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a s... | 02/06/2007 |
| 7169277 | High throughput separations based analysis systems Devices, systems and methods for use in separating sample materials into different fractions that employ bulk fluid flow for loading of samples followed by electrophoretic separation of the sample material. Devices employ configurations that optionally allow bulk sa... | 01/30/2007 |
| 7161356 | Voltage/current testing equipment for microfluidic devices The present invention provides novel methods and devices for testing/verifying the configuration of one or more microfluidic elements in a microfluidic device. In particular the methods and devices of the invention are useful in testing for blockages or the presence... | 01/09/2007 |
| 7160423 | Mixed mode microfluidic systems Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks whi... | 01/09/2007 |
| 7156969 | Microfluidic matrix localization apparatus and methods Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided. ... | 01/02/2007 |
| 7155344 | Distributed database for analytical instruments Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequential... | 12/26/2006 |
| 7153673 | Microfluidic devices and methods for performing temperature mediated reactions In a method for performing a hot start polymerase chain reaction, a reaction mixture including a primer, a template molecule, and a buffer—but no polymerase enzyme—is loaded in a reaction channel of a microfluidic device. An electrical current is applied to heat... | 12/26/2006 |
| 7150999 | Process for filling microfluidic channels The present invention provides novel methods and devices for filling at least one microfluidic channel with a gas or with a degassed fluid. In particular the methods and devices of the invention are useful in completely filling substantially all areas of a microflui... | 12/19/2006 |
| 7150966 | Assay methods and systems Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second reagent is introduced into the first reagent mixture to produce a second r... | 12/19/2006 |
| 7150814 | Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow Methods and apparatus for reducing adsorption in microscale devices are provided. In the methods and apparatus, an electrical current such as an alternating current is applied to materials under pressure-induced flow. Integrated systems for simultaneous control of c... | 12/19/2006 |
| 7138032 | Methods of fabricating polymeric structures incorporating microscale fluidic elements The present invention generally provides improved methods of fabricating polymeric microfluidic devices that incorporate microscale fluidic structures, whereby the fabrication process does not substantially distort or deform such structures. The methods of the inven... | 11/21/2006 |
| 7122659 | Assay methods and systems Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second reagent is introduced into the first reagent mixture to produce a second r... | 10/17/2006 |
| 7105300 | Sequencing by incorporation Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking grou... | 09/12/2006 |
| 7105304 | Pressure-based mobility shift assays Methods for chromatographically separating materials, including the separation of materials in kinase or phosphatase assays, in microfluidic devices under positive or negative fluid pressure. Devices and integrated systems for performing chromatographic separations ... | 09/12/2006 |
| 7101467 | Mixed mode microfluidic systems Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks whi... | 09/05/2006 |
| 7099778 | Method for determining diffusivity and molecular weight in a microfluidic device The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a ... | 08/29/2006 |
| 7091048 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effe... | 08/15/2006 |
| 7081190 | Methods and compositions for performing molecular separations The present invention provides methods of electrophoretically separating macromolecular species, as well as compositions and systems useful in carrying out such methods. Specifically, the methods of the present invention comprise providing a substrate that has at le... | 07/25/2006 |
| 7069952 | Microfluidic devices and methods of their manufacture The present invention provides multi-layered microfluidic devices comprising an interface layer between every two substrate layers. The interface layer simplifies the manufacturing process of the multi-layered devices because the interface may comprise a material su... | 07/04/2006 |
| 7067263 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effe... | 06/27/2006 |
| 7060171 | Methods and systems for reducing background signal in assays Methods and systems of monitoring reactions, e.g., assays, that filter out background signal from substrate, in detecting the product. The methods and systems controllably move detectable reaction product from a first location to a second location at which the produ... | 06/13/2006 |
| 7055695 | Container providing a controlled hydrated environment A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The ope... | 06/06/2006 |
| 7040144 | Microfluidic viscometer Microfluidic devices, systems, and methods measure viscosity, flow times, and/or pressures, other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure ... | 05/09/2006 |
| 7036667 | Container providing a controlled hydrated environment A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The ope... | 05/02/2006 |
| 7038472 | Methods and systems for measuring internal dimensions of microscale structures The present invention provides novel devices for measuring internal dimensions of microscale structures. Methods in accordance with the invention use the voltage measured at a midpoint between a reference structure and a sample structure to determine the resistance ... | 05/02/2006 |
| 7037416 | Method for monitoring flow rate using fluorescent markers Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of flow rate in the various channels of the devices. Signals obtained fr... | 05/02/2006 |
| 7033474 | Microfluidic devices incorporating improved channel geometries The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throu... | 04/25/2006 |
