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| Number | Title | Issue Date |
| 7517974 | Factor VII or VIIa-like molecules Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa co... | 04/14/2009 |
| 7511024 | Factor VII or VIIA-like molecules Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa co... | 03/31/2009 |
| 7432364 | Human TIMP-1 antibodies Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, b... | 10/07/2008 |
| 7138410 | Aza-bicyclic N-biarylamides with affinity for the α7 nicotinic acetylcholine receptor The invention relates to novel 1-aza-bicyclic N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory. ... | 11/21/2006 |
| 7122540 | 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizi... | 10/17/2006 |
| 7112336 | Solid phase dispersion of quinolone or naphthyridonecarboxylic acids The present invention relates to a solid dispersion of quinolone- or naphthyridonecarboxylic acids in an insoluble matrix representative of a shellac, and methods preparing and using the same in masking the taste and improving the uptake by animals. ... | 09/26/2006 |
| 7112597 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic d... | 09/26/2006 |
| 7109218 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same Compounds of the formula (I) a process for their preparation and their use as medicaments are described. ... | 09/19/2006 |
| 7109196 | 1,8 Naphthyridine derivatives and their use to treat diabetes and related disorders The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the inventio... | 09/19/2006 |
| 7098207 | Imidazotriazinones and the use thereof Novel imidazotriazinones of general formula a method for the production and the pharmaceutical use thereof are disclosed. ... | 08/29/2006 |
| 7091198 | 2,5-disubstituted pyrimidine derivatives The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of cent... | 08/15/2006 |
| 7091203 | Imidazo[1,3,5]triazinones and their use The invention relates to imidazo[1,3,5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases. ... | 08/15/2006 |
| 7091228 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... | 08/15/2006 |
| 7071207 | Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds... | 07/04/2006 |
| 7041646 | Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 05/09/2006 |
| 6998483 | Process for the preparation of sulphonamide-substituted imidazotriazinones The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) | 02/14/2006 |
| 6998402 | Substituted imidazotriazinones The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memory retentiveness. ... | 02/14/2006 |
| 6995170 | Semi-hydrochloride of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid The present invention relates to a semi-hydrochloride of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, to processes for its preparation and to antibacterial compositions comprising it. The s... | 02/07/2006 |
| 6994956 | Method for assaying enzyme activity The present invention relates to methods for assessing enzyme activity utilizing a phase partition system. In addition, the present invention also relates to methods for screening and identifying compounds that may be used, for example, for the treatment of diabetes... | 02/07/2006 |
| 6984387 | Immunogenic peptides of foot-and-mouth disease viruses The present invention relates to FMDC vaccine based on peptides having a sequence of at least 8 amino acids, which corresponds to a partial sequence of the non-structural protein region of FMDV, which was selected by immunoreactivity with FMDV-specific antibodies or... | 01/10/2006 |
| 6972319 | Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use This invention provides novel peptides that function in vivo to stimulate insulin release from pancreatic beta cells in a glucose-dependent fashion. These insulin secretagogue peptides are shown to stimulate insulin release in rat islet cells in vitro, and in vivo. ... | 12/06/2005 |
| 6964971 | 1,6-naphthyridine derivatives and their use to treat diabetes and related disorders The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention rela... | 11/15/2005 |
| 6960601 | Preparation and use of imidazole derivatives for treatment of obesity This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of us... | 11/01/2005 |
| 6943163 | 7-Alkyl and cycloalkyl-substituted imidazotriazinones The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases. ... | 09/13/2005 |
| 6943182 | Cyclopentabenzofuran derivatives and their use The invention relates to cyclopentabenzofuran derivatives, process for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-κB-dependent diseases and medicaments which contain the cyclopentabenzofur... | 09/13/2005 |
| 6936609 | Imidazotriazines for use as phosphodiesterase inhibitors The invention relates to new imidazotriazines, processes for their preparation, and their use for the production of medicaments for the treatment and/or prophylaxis of neurodegenerative disorders, in particular Parkinson's disease. ... | 08/30/2005 |
| 6930108 | Use of 2-alkoxyphenol-substituted imidazotriazinones The present invention relates to the use of known 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position and cGMP PDE-inhibitory properties for the production of medicaments for the treatment of cardiac insufficiency, psori... | 08/16/2005 |
| 6930114 | Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer. ... | 08/16/2005 |
| 6919360 | Benzisothiazolyl-substituted aminomethyl chromanes for treating diseases of the central nervous system The present invention relates to chromans, to processes for their preparation and to their use in medicaments, in particular as agents for treating disorders of the central nervous system. ... | 07/19/2005 |
| 6919371 | 2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions. ... | 07/19/2005 |
| 6919470 | Aryl and heteroaryl sulfonates The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating pain and neurodegenerative dis... | 07/19/2005 |
| 6903218 | Sulfonamide substituted chroman derivatives This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions. ... | 06/07/2005 |
| 6900205 | 1,8-Naphthyridine derivatives and their use to treat diabetes and related disorders The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention rela... | 05/31/2005 |
| 6890922 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizi... | 05/10/2005 |
| 6878708 | Imidazotriazinones and the use thereof Novel imidazotriazinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed. ... | 04/12/2005 |
| 6864069 | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 03/08/2005 |
| 6838459 | 7-alkyl-and cycloalkyl-substituted imidazotriazinones The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases. ... | 01/04/2005 |
| 6803365 | Imidazo[1,3,5]triazinones and the use thereof The invention relates to imidazo[1.3.5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases. ... | 10/12/2004 |
| 6797714 | Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions. ... | 09/28/2004 |
| 6794406 | Indole derivatives The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments. ... | 09/21/2004 |
