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| Number | Title | Issue Date |
| 8148512 | Methods for detection and quantification of analytes in complex mixtures The invention provides a diverse population of uniquely labeled probes, containing target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of detecting a nucleic acid analyte. The method consists of (a) ... | 04/03/2012 |
| 8088160 | Drug-eluting intravascular prostheses and methods of use The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth... | 01/03/2012 |
| 8080417 | Methods of ex vivo hematopoietic stem cell expansion by co-culture with mesenchymal cells Methods of ex-vivo expansion and at the same time inhibiting differentiation of stem cells by co-culture with mesenchymal cells, transplantable populations of renewable progenitor and stem cells expanded thereby, and their uses in therapeutic applications. ... | 12/20/2011 |
| 8075922 | Method of co-infusing a deoxygenated hemoglobin containing blood substitute and inorganic nitrite Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very stable iron nitrosyl hemoglobin which on delivery into the body i... | 12/13/2011 |
| 8071557 | Treatment of pulmonary hypertension with carbonic anhydrase inhibitors This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically ef... | 12/06/2011 |
| 8049005 | Substituted tetrahydropyrazolo-pyrido-azepine compounds The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds... | 11/01/2011 |
| 8039503 | Lapachone compounds and methods of use thereof The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphtho... | 10/18/2011 |
| 8039217 | Proteomic interaction and genomic action determinations in the presence of associated redox state conditions Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are correlated with oxygen tensions. Identification of markers for disease includ... | 10/18/2011 |
| 8022195 | Vectors encoding cell growth and adhesion factors for simultaneous growth and adhesion of cells The present invention relates to endothelial and smooth muscle cells genetically altered to express or over-express one or more cell adhesion factors. The invention further relates to cells genetically altered to express or over-express both cell proliferation growt... | 09/20/2011 |
| 7981863 | Treatment of Parkinson's disease with PDGF The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent th... | 07/19/2011 |
| 7973154 | Kits for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The ... | 07/05/2011 |
| 7968533 | Ethyl nitrite as a gastrointestinal smooth muscle relaxant and diagnostic and therapeutic uses thereof The present invention provides compositions comprising a gas and a gastrointestinal smooth muscle relaxing agent comprising ethyl nitrite in a therapeutically effective amount. The present invention also provides methods of relaxing gastrointestinal smooth muscle, a... | 06/28/2011 |
| 7960158 | Kinase inhibition models and their uses The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention can be used to design or screen for inhibitors for kinases. ... | 06/14/2011 |
| 7960134 | Kinase inhibition models and their uses The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention can be used to design or screen for inhibitors for kinases. ... | 06/14/2011 |
| 7955852 | Expansion of renewable stem cell populations Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses. ... | 06/07/2011 |
| 7943590 | Compositions and methods for treating ophthalmic disorders The present invention relates to compositions and methods for treating and/or preventing ocular disorders, diseases or conditions and compositions and methods for treating or preventing ophthalmic conditions and disorders in a subject in need thereof. ... | 05/17/2011 |
| 7914982 | Methods for detecting pathogen specific nucleic acids in urine The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at... | 03/29/2011 |
| 7887581 | Methods of hemodialysis utilizing grafts coated with cells expressing human fibulin-5 The present relates to artificial vascular grafts and for methods for performing hemodialysis with the same. The grafts comprise an inner surface on which cells genetically altered to express or over-express one or more cell adhesion factors, such as fibulin-5, or o... | 02/15/2011 |
| 7855075 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 12/21/2010 |
| 7811822 | Modulation of neural stem cells and neural progenitor cells The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent th... | 10/12/2010 |
| 7803929 | Kits for diagnosis and monitoring of pathogenic infection by analysis of cell-free pathogenic nucleic acids in urine The present invention relates to a method for diagnosing and/or monitoring a bacterial or parasitic infection by detection and quantification of the transrenal nucleic acids, derived from bacterial pathogenic agents or from parasites, in urine. The detection method ... | 09/28/2010 |
| 7790765 | Hydroxy sulfonate of quinone compounds and their uses The present invention provides sodium 6-hydroxy-2,2-dimethyl-5-oxo-3,4,5,6-tetrahydro-2H-benzo(h)chromene-6-sulfonate, and its synthesis and uses in the treatment of cancer. ... | 09/07/2010 |
| 7767201 | Vascular cells genetically altered to over-express angiogenic proliferation and maturation factors; treatment of atherosclerosis using same This invention relates to a method for producing angiogenesis in a tissue of a patient by administering vascular cells genetically altered to over-express an angiogenic proliferation factor and an angiogenic maturation factor to the affected tissue. ... | 08/03/2010 |
| 7718578 | Method of synthesis and testing of combinatorial libraries using microcapsules The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming seco... | 05/18/2010 |
| 7649013 | Methods of protecting against radiation injury Administration of a modulator of cell cycle checkpoint activation, which is preferably β-lapachone, or a pharmaceutically acceptable salt, prodrug, metabolite, analog or derivative thereof, protects normal cells against radiation injury. The invention includes meth... | 01/19/2010 |
| 7646484 | Method and apparatus for performing optical measurements of a material A method of determining an optical parameter or function thereof for a liquid, the method comprising: flowing the liquid through a flow cell; transmitting a pulse of light into the liquid in the flow cell; generating a signal responsive to energy that the material e... | 01/12/2010 |
| 7563278 | Drug-eluting intravascular prostheses and methods of use The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth... | 07/21/2009 |
| 7511036 | Dihydrothiazine prodrugs of thiazolium agents Provided are compounds of the formula (and pharmaceutically acceptable salts thereof): wherein: R is hydrogen, methyl, hydroxymethyl or α-hydroxyethyl; R... | 03/31/2009 |
| 7432254 | Method for treating glaucoma IC Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation im... | 10/07/2008 |
| 7429489 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 09/30/2008 |
| 7364725 | Endothelial cells engineered to express or overexpress fibulin-5 and a growth factor The present invention relates to endothelial and smooth muscle cells genetically altered to express or over-express one or more cell adhesion factors. The invention further relates to cells genetically altered to express or over-express both cell proliferation growt... | 04/29/2008 |
| 7361691 | Method of treating cancers using β-lapachone or analogs or derivatives thereof Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic kinase modulator, preferably imatinib. This combination of the cell cyc... | 04/22/2008 |
| 7344881 | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least... | 03/18/2008 |
| 7329543 | Red blood cells loaded with -nitrosothiol and uses therefor Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized b... | 02/12/2008 |
| 7312078 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 12/25/2007 |
| 7247700 | BID polypeptides and methods of inducing apoptosis Disclosed herein are novel polypeptides and the nucleic acid sequences that encode them. Also disclosed are antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, ... | 07/24/2007 |
| 7189837 | Cell surface molecule-induced macrophage activation This invention provides compositions, such as capsules, comprising transformed cells that express immunostimulatory cell surface polypeptides which are expressed on the cell surface and are capable of stimulating an immune response against the cell in a host. ... | 03/13/2007 |
| 7179791 | Inhibiting GS-FDH to modulate NO bioactivity Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase. ... | 02/20/2007 |
| 7175658 | Artificial vascular grafts, their construction and use The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on which cells genetically altered to express or over-express one or more c... | 02/13/2007 |
| 7169605 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 01/30/2007 |
