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| Number | Title | Issue Date |
| 6495665 | Isoforms of mouse serotonin 5-HT2C receptor The invention includes mouse serotonin 5-HT2c receptor isoforms having amino acid replacements at one or more positions of the natural mouse serotonin 5-HT2c receptor polypeptide sequence, specifically at one or more of positions 157, 159 and 161. The pol... | 12/17/2002 |
| 6387911 | Pyrazinone thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is ##STR2##... | 05/14/2002 |
| 6362190 | Method for treating inflammatory diseases by administering a thrombin inhibitor The invention is a method for treating an inflammatory disease in a patient which comprises treating the patient with an oral composition comprising a thrombin inhibitor. Such diseases include but are not limited to nephritis, systemic lupus erythematosus... | 03/26/2002 |
| 6350745 | Thrombin inhibitors Compounds of the invention, useful as thrombin inhibitors and having therapeutic value in for example, preventing coronary artery disease, have the following structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is ##STR2## whe... | 02/26/2002 |
| 6294549 | Method for eliciting an v댥 or dual v댣/v댥 antagonizing effect A method for eliciting an vଲ.sub.5 or dual vଲ.sub.3 /vଲ.sub.5 antagonizing effect in a mammal which comprises administering to the mammal a therapeutically effective amount of a compo... | 09/25/2001 |
| 6262031 | Method for treating pediculosis capitisinfestation A method for treating Pediculosis capitis infestation in a human patient which comprises orally administering to the human a total amount of ivermectin of between about 400 ug/kg and about 1200 ug/kg over a period of time of about one week, wherein equal ... | 07/17/2001 |
| 6232315 | Method for treating inflammatory diseases by administering a thrombin inhibitor The invention is a method for treating an inflammatory disease in a patient which comprises treating the patient with a composition comprising a thrombin inhibitor. Such diseases include but are not limited to nephritis, systemic lupus erythematosus, rheu... | 05/15/2001 |
| 6210904 | Anticoagulant test The present invention is a method for diagnosing a patient at risk to thrombocytopenia induced by administration of a GP IIb/IIIa receptor antagonist, which comprises combining i) a plasma sample of the patient; ii) detectable monoclonal antibody which recogni... | 04/03/2001 |
| 6166181 | Human adenosine receptors The invention concerns recombinant human adenosine receptors A1, A2a, A2b and A3 which have been prepared by cDNA cloning and polymerase chain reaction techniques. The invention also concerns expression systems for these receptors and an assay using the e... | 12/26/2000 |
| 6147078 | Pyrazinone thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein ##STR2##... | 11/14/2000 |
| 6136794 | Platelet aggregation inhibition using low molecular weight heparin in combination with a GP IIb/IIIa antagonist A method for inhibiting platelet aggregation in a mammal comprising administering to the mammal a safe and therapeutically effective amount of a GPIIb/IIIa receptor antagonist or a pharmaceutically acceptable salt thereof and a safe and therapeutically ef... | 10/24/2000 |
| 6136804 | Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis, thromboembolism, thrombotic occlusion and reocclusion, restenosis,... | 10/24/2000 |
| 6133297 | Thrombin inhibitors A compound which inhibits human thrombin and which has the general structure ##STR1## such as ##STR2##... | 10/17/2000 |
| 6129932 | Compositions for inhibiting platelet aggregation The invention is a pharmaceutical composition for oral administration to a patient comprising pharmaceutically effective amount of [3(R)-[2-Piperidin-4-yl)ethyl]-2-piperidone-1]acetyl-3(R)-methyl-ଲ-al anine, or a pharmaceutically acceptable salt ther... | 10/10/2000 |
| 6117842 | Fibrinogen receptor antagonists Compounds of this invention have the formula: X--(CH2)n --C(O)NH--A--C(COOR5)R3 R4 or a pharmaceutically acceptable salt thereof, e.g. ##STR1## which are useful for inhibiting fibrinogen binding to blood p... | 09/12/2000 |
| 6117888 | Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:... | 09/12/2000 |
| 6093717 | Imidazopyridine thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein Y1 and Y2 are independently selected from the group consisting of hydrogen, C | 07/25/2000 |
| 6087373 | Thrombin inhibitors A compound which inhibits human thrombin and which has the general structure ##STR1##... | 07/11/2000 |
| 6063584 | Anticoagulant test The present invention is a method for identifying a patient at risk to developing fibrinogen receptor antagonist-induced thrombocytopenia which comprises incubating patient plasma with a GPIIb/IIIa receptor:GPIIb/IIIa receptor antagonist complex to form a... | 05/16/2000 |
| 6040317 | Sulfonamide fibrinogen receptor antagonists A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.... | 03/21/2000 |
| 6017934 | Thrombin inhibitors A compound which inhibits human thrombin and where has the structure ##STR1##... | 01/25/2000 |
| 6011038 | Pyrazinone thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## for example: ##STR2##... | 01/04/2000 |
| 6004976 | Thrombin inhibitors A compound which inhibits human thrombin and where has the structure ##STR1## such as ##STR2##... | 12/21/1999 |
| 5990107 | Fibrinogen receptor antagonist prodrugs Fibrinogen receptor antagonist alcohol prodrugs having the structure, for example, of ##STR1## more particularly, ##STR2##... | 11/23/1999 |
| 5989588 | Methods and compositions for preventing and treating heartburn A method for preventing heartburn episodes in a patient at risk to development of heartburn, comprising administering to the patient, following the heartburn inducing event but prior to development of heartburn, a composition comprising a pharmaceutically... | 11/23/1999 |
| 5981584 | Fibrinogen receptor antagonist prodrugs Fibrinogen receptor antagonist prodrugs having the structure, for example, of ##STR1## more particularly, ##STR2##... | 11/09/1999 |
| 5980951 | Oral coated active drugs An oral drug dosage unit, for administration to a patient, having active drug, and an effective diameter and surface composition sufficient for the unit to be transported from the stomach into the duodenum following substantially complete emptying of chym... | 11/09/1999 |
| 5978698 | Angioplasty procedure using nonionic contrast media A method for treating patients in need of percutaneous transluminal coronary angioplasty which comprises administering nonionic contract media to the patient and treating the patient with a fibrinogen receptor antagonist.... | 11/02/1999 |
| 5972967 | Compositions for inhibiting platelet aggregation The invention is a pharmaceutical composition for intravenous administration to a patient comprising a) a pharmaceutically effective amount of 2-S-(n-Butylsulfonylamino)-3-[4-(4-(piperidin-4-yl)butyloxy)phenyl]propion ic acid; b) a pharmaceutically accepta... | 10/26/1999 |
| 5965581 | Compositions for inhibiting platelet aggregation A composition is disclosed comprising about 0.25 mg/ml 2-S-(n-Butylsulfonylamino)-3 -[4-(4-(piperdin-4-yl)butyloxylphenyl]propionic acid, about 8 mg/ml sodium chloride, about 2.7 mg/ml sodium citrate dihydrate, about 0.16 mg/ml citric acid anhydrous,... | 10/12/1999 |
| 5952306 | Integrin receptor antagonists Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2## which are useful for inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.... | 09/14/1999 |
| 5945545 | Fibrinogen receptor antagonists Compounds of this invention have the formula: ##STR1## and pharmaceutically acceptable salts, e.g. ##STR2##... | 08/31/1999 |
| 5932582 | Fibrinogen receptor antagonist prodrugs Fibrinogen receptor antagonist alcohol prodrugs having the structure, for example, of X--W--Y--Z--A--B more particularly, ##STR1##... | 08/03/1999 |
| 5932606 | Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors A compound which inhibits human thrombin and where has the structure and pharmaceutically acceptable salts thereof, wherein such as ##STR1## which are useful for inhibiting formation of blood platelet aggregates in blood in a mammal.... | 08/03/1999 |
| 5929120 | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption Compounds of the following general structure X--Y--Z-Aryl-A--B, ##STR1## which inhibit osteoclast mediated bone resorption.... | 07/27/1999 |
| 5900414 | Methods for administering integrin receptor antagonists The compositions and methods of the invention provide a convenient means for systemically administering an integrin receptor antagonist or a pharmaceutically effective amount thereof to a patient by introducing the antagonist, in an ophthalmic formulation... | 05/04/1999 |
| 5889023 | Fibrinogen receptor antagonist A fibrinogen receptor antagonist which is 3(R)-2-(Piperidin-4-yl)ethyl!-2-piperidon-1-ylacetyl-3(S)-(3-pyridyl)-.be ta.-alanine.... | 03/30/1999 |
| 5880136 | Sulfonamide fibrinogen receptor antagonists A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.... | 03/09/1999 |
| 5872138 | Thrombin inhibitors A compound which inhibits human thrombin and which has the general structure ##STR1##... | 02/16/1999 |
| 5869487 | Pyrido3,4-B!pyrazines for use as thrombin inhibitors A compound which inhibits human thrombin and where has the structure ##STR1##... | 02/09/1999 |
