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| Number | Title | Issue Date |
| 8148332 | Method for treating a rheumatic disease using a soluble TLA4 molecule The present invention relates to compositions and methods for treating rheumatic diseases, such as psoriasis arthropathica, by administering to a subject a CTLA4 molecule that block endogenous B7 molecules from binding their ligands. ... | 04/03/2012 |
| 7915395 | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette comprising ... | 03/29/2011 |
| 7915222 | Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis The invention relates to methods and compositions for treating undifferentiated arthritis (UA) and/or preventing the development of rheumatoid arthritis (RA) in subjects with UA by administering to a subject in need thereof an effective amount of soluble CTLA4 molec... | 03/29/2011 |
| 7829534 | Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules The present invention is a method of inhibiting islet cell transplant rejection particular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 muta... | 11/09/2010 |
| 7705134 | Antibodies that bind to BGS-4 The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The ... | 04/27/2010 |
| 7700556 | Methods of treatment using CTLA4 mutant molecules The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domai... | 04/20/2010 |
| 7678887 | Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16... | 03/16/2010 |
| 7671022 | Methods for treating cardiovascular disease using a soluble CTLA4 molecule The present invention relates to compositions and methods for treating cardiovascular system diseases by administering to a subject soluble CTLA4 molecules that block endogenous B7 molecules from binding their ligands. ... | 03/02/2010 |
| 7670785 | Polynucleotides and polypeptides associated with the development of rheumatoid arthritis The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polyp... | 03/02/2010 |
| 7572772 | Soluble CTLA4 mutant molecules The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fus... | 08/11/2009 |
| 7541164 | Mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise at least two temp... | 06/02/2009 |
| 7528111 | Method of vaccinating subjects receiving immune modulating therapy The present invention relates to methods of vaccinating subjects receiving immune modulating therapy, such as soluble CTLA4 molecules, for treatment of immune system diseases mediated by T-cell interactions with B7-positive cells including, but not limited to, autoi... | 05/05/2009 |
| 7510844 | CD86 and CD80 receptor competition assays The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies. ... | 03/31/2009 |
| 7482327 | Methods for treating immune disorders associated with graft transplantation with soluble CTLA4 mutant molecules The present invention provides use of soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig in the treatment of immune disorders associated with graft transplantation. ... | 01/27/2009 |
| 7455835 | Methods for treating immune system diseases using a soluble CTLA4 molecule The present invention relates to compositions and methods for treating rheumatic disease by administering to a subject, soluble CTLA4 molecules that block endogenous B7 molecules from binding their ligands. ... | 11/25/2008 |
| 7456256 | BGS 4 The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present inven... | 11/25/2008 |
| 7439230 | Methods of treatment using CTLA4 mutant molecules The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domai... | 10/21/2008 |
| 7416876 | N-carbobenzyloxy (N-CBZ)-deprotecting enzyme This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encodin... | 08/26/2008 |
| 7332303 | Product quality enhancement in mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-gal... | 02/19/2008 |
| 7307064 | Methods for treating cardiovascular disease using a soluble CTLA4 molecule The present invention relates to compositions and methods for treating cardiovascular system diseases by administering to a subject soluble CTLA4 molecules that block endogenous B7 molecules from binding their ligands. ... | 12/11/2007 |
| 7244573 | Polynucleotides and polypeptides associated with the development of rheumatoid arthritis The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polyp... | 07/17/2007 |
| 7223558 | Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention furt... | 05/29/2007 |
| 7198911 | Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16... | 04/03/2007 |
| 7119188 | N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants and fragments thereof, that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nuc... | 10/10/2006 |
| 6916796 | Use of pullulan as a slowly digested carbohydrate The present invention is directed to the use of pullulan as a slowly digested carbohydrate and to its incorporation into food products, especially beverages and meal replacement products. ... | 07/12/2005 |
| 6774111 | Carbohydrate system and a method for providing nutrition to a diabetic The two carbohydrate mixture of this invention utilizes a source of fructose in combination with at least one readily digestible glucose polymer source. The addition of the fructose significantly decreases the glycemic response when compared to the digestible glucos... | 08/10/2004 |
| 6705108 | Nested cooler system A nested cooler system for temporary storage of perishable food stuffs and more particularly to articles for convenient, temporary storage of human breast milk and infant formulas. The inner and outer coolers jointly or independently receive the perishable foodstuff... | 03/16/2004 |
| 6472003 | Powdered human milk fortifier The invention relates to a powdered human milk fortifier comprising a protein component typically present in an amount of from about 24 wt/wt % to about 55 wt/wt % of the fortifier powder, and a fat component typically present in an amount of from about 1... | 10/29/2002 |
| 6440470 | Elemental enteral nutritional product The present invention is directed to an elemental liquid nutritional product useful for providing nutrition to a patient having a malabsorption condition by enterally feeding to the patient a nutritionally effective amount of the liquid nutritional produc... | 08/27/2002 |
| 6427475 | Nested cooler system A nested cooler system for temporary storage of perishable foodstuffs and more particularly to articles for convenient, temporary storage of human breast milk and infant formulas. The inner and outer coolers jointly or independently receive the perishable... | 08/06/2002 |
| 6423347 | Method and product using sturgeon notochord for alleviating the symptoms of arthritis This invention provides a composition comprising notochord and extracts thereof in therapeutic amounts. The invention more specifically relates to a method of treating arthritis in mammals, more particularly rheumatoid arthritis in humans through the ente... | 07/23/2002 |
| 6372782 | Soy-based nutritional products The present invention relates generally to a complete nutritional product that provides soy protein and enhanced levels of isoflavones. Preferably, the soy protein comprises at least 0.7 mg isoflavones/gm soy protein and at least 0.5 mg genistein/gm soy p... | 04/16/2002 |
| 6248375 | Diabetic nutritionals and method of using The present invention is directed to solid matrix nutritionals designed for the person with diabetes. The carbohydrate system of this invention utilizes a source of fructose in combination with at least one nonabsorbent carbohydrate to achieve the same ef... | 06/19/2001 |
