Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 5935978 | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical c... | 08/10/1999 |
| 5808093 | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo2.2.1!heptane compound and the preparation of 2-azabicyclo2.2.1!heptane compounds A compound of formula ##STR1## wherein R is a group of formula ##STR2## R1 is alkyl; and Ar is optionally substituted aryl.... | 09/15/1998 |
| 5731315 | Substituted sulfonic acid n-(aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of ... | 03/24/1998 |
| 5698711 | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical c... | 12/16/1997 |
| 5676831 | Isoindolinone derivative, preparation thereof and pharmaceutical compositions containing same The present invention relates to a new isoindolinone derivative of formula: ##STR1## in racemic form or in the form of its enantiomers, as well as its salts, its preparation and the pharmaceutical compositions which contain it.... | 10/14/1997 |
| 5670649 | Derivatives of 2-azabicyclo2.2.1!heptane, their preparation and their application Novel derivatives of 1R- or 1S-2-azabicyclo2.2.1!heptane with the general formula (I) or (I'), their preparation and their application. ##STR1## In the general formulas (I) and (I'), R represents a hydrogen atom or a group with the formula ##S... | 09/23/1997 |
| 5347039 | Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one with a borohydride in the presence of titanium derivative.... | 09/13/1994 |
| 5304660 | Pyran derivatives The invention provides compounds of formula (I) wherein R1 represents alkyl, R2 represents an acid-labile protecting group and X1 represents a halogen atom, which are useful in the synthesis of mevalonic acid derivatives. ... | 04/19/1994 |
| 5258544 | Synthesis of aldehydes useful in the preparations of HMG-CoA reductase inhibitors Disclosed is a process for the preparation of 2-aryl-1-cyclohexene-1-carboxaldehydes from 1-arylcyclohexenes which are intermediates for trans-6-[(2-arylsubstituted cycloalkenyl and substituted cycloalkyl)alkenyl and alkyl]-3,4,5,6-tetrahydro-2H-pyran-2-o... | 11/02/1993 |
| 5248830 | Enantioselective preparation of acetylenic or olefinic substituted cycloalkenyl dihydroxybutyrates and 4-hydroxy-tetrahydro-pyran-2-ones Disclosed are intermediates and a process of making an anticholesterolemic compound of the formula ##STR1## the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.... | 09/28/1993 |
| 5240948 | 3-(3-alkylthiopropyl)benzothiazoline derivatives, their preparation and the medicament containing them Compounds of formula: ##STR1## in which R1 represents a polyfluoroalkoxy radical and R2 represents an alkylthio, alkylsulphinyl or alkylsulphonyl radical, their salts, their preparation and the medicaments containing them.... | 08/31/1993 |
| 5132312 | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically ac... | 07/21/1992 |
