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| Number | Title | Issue Date |
| 6852701 | Anticonvulsant derivatives useful for preventing the development of Type II diabetes mellitus and Syndrome X Anticonvulsant derivatives useful for preventing the development of Type II diabetes mellitus and Syndrome X are disclosed. ... | 02/08/2005 |
| 6750034 | DNA encoding human serine protease D-G Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed D-G. The deduced amino acid sequence, and it's alignment with other well characterized serine proteases clearly indicates that it is a member of the S1 serine pro... | 06/15/2004 |
| 6627653 | Anticonvulsant derivatives useful for the treatment of depression Anticonvulsant derivatives useful for treating depression as monotherapy or combination therapy are disclosed.... | 09/30/2003 |
| 6583172 | Anticonvulsant derivatives useful in treating chronic neurodegenerative disorders Anticonvulsant derivatives useful in treating chronic neurodegenerative conditions are disclosed.... | 06/24/2003 |
| 6552000 | Anticonvulsant derivatives useful in treating autism Anticonvulsant derivatives useful in treating autism.... | 04/22/2003 |
| 6495523 | Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration Anticonvulsant compounds of the general formula I: ##STR1## where X, R1, R2, R3, R4, R5, and R6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such ... | 12/17/2002 |
| 6362220 | Anticonvulsant derivatives useful in reducing blood glucose levels Anticonvulsant derivatives useful in reducing blood glucose levels are disclosed.... | 03/26/2002 |
| 6339105 | Analgesic regimen A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower percentage of discontinuations of therapy due to a lower inci... | 01/15/2002 |
| 6201025 | N-aralkylaminotetralins as ligands for the neuropeptide Y Y5 receptor ଲ-Aminotetralin derivatives of the formula: ##STR1## which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing a ଲ-aminotetralin derivative as the active ingredient are descr... | 03/13/2001 |
| 6200984 | Naphtho-imidazo pyridine derivatives useful in treating central nervous system disorders A compound of the general formula I: ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions, processes for preparing the compounds and methods of treatment are also disclosed.... | 03/13/2001 |
| 6201010 | Anticonvulsant derivatives useful in lowering blood pressure Anticonvulsant derivatives useful in lowering blood pressure in overweight individuals.... | 03/13/2001 |
| 6191163 | Anticonvulsant derivatives useful in lowering lipids Anticonvulsant derivatives useful in lowering lipids.... | 02/20/2001 |
| 6156732 | Azole peptidomimetics as thrombin receptor antagonists Azole derivatives of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.... | 12/05/2000 |
| 6140354 | N-substituted aminotetralins as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders ଲ-Aminotetralin derivatives of the formula: ##STR1## which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing a ଲ-aminotetralin derivative as the active ingredient are ... | 10/31/2000 |
| 6069254 | Carboxamide derivatives of piperidine for the treatment of thrombosis disorders Carboxamide derivatives of pyrrolidine, piperidine, and hexahydroazepine of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.... | 05/30/2000 |
| 5968946 | Heterocyclic derivatives useful in treating central nervous system disorders This invention relates to a series of substituted 3-oxo-pyrrolo[1,2-a]imidazopyridine derivatives of the formula 1 ##STR1## where X1 -X4, R1, R2 and Ar are defined herein. In addition the invention relates ... | 10/19/1999 |
| 5935933 | Anticonvulsant derivatives useful in treating neuropathic pain Anticonvulsant derivatives useful in treating neuropathic pain including but not limited to neuralgia are disclosed.... | 08/10/1999 |
| 5817668 | S-heteroatom containing alkyl substituted-3-oxo-pyrido1,2-A!benzimidozole-4-carboxamide derivatives useful in treating central nervous system disorders A compound of the general formula 1; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.... | 10/06/1998 |
| 5770575 | Nipecotic acid derivatives as antithrombotic compounds Nipecotic acid-derived compounds of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.... | 06/23/1998 |
| 5760006 | Anticonvulsant derivatives useful in treating psoriasis The use of compounds of the following formula I: ##STR1## for treating psoriasis is disclosed.... | 06/02/1998 |
| 5760007 | Anticonvulsant derivatives useful in treating neuropathic pain Anticonvulsant derivatives useful in treating neuropathic pain are disclosed.... | 06/02/1998 |
| 5753655 | 1-arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation 1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and processes for making said derivatives are described. The novel derivatives are non-steroidal heterocyclic compounds which act as selective progestins and/or antiprogestins havin... | 05/19/1998 |
| 5753694 | Anticonvulsant derivatives useful in treating amyotrophic lateral sclerosis (ALS) Disclosed herein is a method of treating amyotrophic lateral sclerosis with topiramate and related compounds.... | 05/19/1998 |
| 5753693 | Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder This application relates to the use of topiramate and related sulfonamides for the treatment of manic-depressive bipolar disorder.... | 05/19/1998 |
| 5639760 | 3-oxo-pyrido(1,2-a)-benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)-benzimidazole-5-carboxyl derivatives useful in treating central system disorders The present invention is directed to compounds of the following formula I: ##STR1## wherein R, R1, R2, R3, R4, A, n, X, and Y are as defined hereinafter. The compounds of formula I are useful in treating ce... | 06/17/1997 |
| 5635208 | Granulation process for producing an acetaminophen and diphenhydramine hydrochloride composition and composition produced by same A granulation process for preparing a solid dosage form containing acetaminophen and diphenhydramine hydrochloride, as active agents is disclosed. In addition, the solid dosage form produced by the process is described.... | 06/03/1997 |
| 5569659 | 4-arylpiperazines and 4-arylpiperidines Compounds of the general formula I: ##STR1## are disclosed as novel antipsychotic agents.... | 10/29/1996 |
| 5532226 | Trifluoromethybenzylphosphonates useful in treating osteoporosis Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.... | 07/02/1996 |
| 5523308 | Peptidyl heterocycles useful in the treatment of thrombin related disorders Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.... | 06/04/1996 |
| 5516803 | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug This invention relates to a composition comprising a tramadol material and a nonsteroidal antiinflammatory drug, and its use. The compositions are pharmacologically useful in treating pain and tussive conditions. The compositions are also subject to less ... | 05/14/1996 |
| 5512566 | Tricyclic compounds having affinity for the 5-HT1A receptor Compounds represented by the general formula I: ##STR1## are disclosed as useful in treating diseases of the central nervous system.... | 04/30/1996 |
| 5508273 | Substituted phosphonic acids and derivatives useful in treating bone wasting diseases Compounds represented by the formula I: ##STR1## are disclosed as agents for use in treating bone wasting diseases.... | 04/16/1996 |
| 5498629 | Anticonvulsant pseudofructopyranose sulfamates A compound of the general formula I: ##STR1## is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.... | 03/12/1996 |
| 5468744 | Composition comprising a tramadol material and any of codeine, oxycodone or hydrocodone and their use This invention relates to compositions comprising a tramadol material selected from the group consisting of tramadol, its stereoisomers and its pharmaceutically acceptable salts and either codeine or oxycodone, and their use in treating pain. When the com... | 11/21/1995 |
| 5387693 | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole intermediate compounds Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also d... | 02/07/1995 |
| 5384327 | Anticonvulsant sorbopyranose sulfamates Sulfamate derivatives having the following formula (I): ##STR1## wherein R1, R2, R3, R4, R5, and R6 are as herein defined, have been found to exhibit anticonvulsant activity and are th... | 01/24/1995 |
| 5380869 | Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate ... | 01/10/1995 |
| 5336691 | Composition comprising a tramadol material and acetaminophen and its use This invention relates to a composition comprising a tramadol material and acetaminophen, and its use. As used herein tramadol refers to various forms of tramadol. The compositions are pharmacologically useful in treating pain and tussive conditions. The ... | 08/09/1994 |
| 5332732 | Thiophene and pyridine antipsychotic agents Compounds of the general formula I ##STR1## wherein A is N; Ar is aryl, substituted aryl or benzofuranyl, wherein the substituents are selected from C1 -C8 alkoxy; B is CO or CH2 and HET is selected from any of piperi... | 07/26/1994 |
| 5332743 | Benzyl and benzhydryl alcohols Compounds of the general formula I: ##STR1## are disclosed as potent antipsychotic agents. Novel methods of use and intermediates used to make the compounds of formula I are also disclosed.... | 07/26/1994 |
