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...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
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| Number | Title | Issue Date |
| 7060506 | Compositions and methods for monitoring the modification of modification dependent binding partner polypeptides The invention provides methods and compositions for monitoring enzymatic activity as a function of the interaction of modification dependant binding partner polypeptides. Association or dissociation of the binding partner polypeptides is dependant upon the addition ... | 06/13/2006 |
| 7058658 | Molecular database for antibody characterization The invention relates to a cumulative, evolving molecular database of monospecific probes and their characteristics. In particular, the invention relates to a computer repository of histograms based upon quantitative flow cytometry. The invention further relates to ... | 06/06/2006 |
| 7037691 | Kinase mimic catalysts for asymmetric synthesis of phosphorylated inositols and cycloalkanols The present invention provides peptide-based phosphorylation catalysts (PBPC's) for the asymmetric monophosphorylation of cyclitols, particularly myo-inositols. The PBPC's of the invention effect a regio and enantioselective phosphorylation of a myo-inositol in a ma... | 05/02/2006 |
| 7005617 | Apparatus and method for thermally cycling samples of biological material with substantial temperature uniformity An apparatus for thermally cycling samples of a biological material including a thermal block assembly including a plurality of sample holders for receiving samples of biological material; a heat sink thermally coupled to the thermal block assembly, the heat sink tr... | 02/28/2006 |
| 6996477 | Computational subtraction method The invention provides a method and system for performing computational subtraction to detect microbes within a host organism. In some aspects, the microbes are pathogens and the system is used to identify sequences belonging to these pathogens which can then be use... | 02/07/2006 |
| 6972198 | Methods and compositions using protein binding partners The invention relates to a method for determining the conformational state of a protein, comprising the steps of: a) providing a first binding partner which is capable of binding to the protein in a manner dependent on the conformational state of the protein and whi... | 12/06/2005 |
| 6972182 | Methods and compositions using coiled binding partners The present invention relates to a polypeptide multimer comprising a first polypeptide having associated therewith a label and a second polypeptide, wherein a) at least one of the polypeptides is susceptible to protease digestion; b) association of the polypeptides ... | 12/06/2005 |
| 6962974 | Anti-angiogenic proteins and fragments and methods of use thereof Proteins with anti-angiogenic properties are disclosed, and fragments thereof, and methods of using those proteins and fragments to inhibit or promote angiogenesis. ... | 11/08/2005 |
| 6958216 | DNA-bridged carbon nanotube arrays A class of biological sensing devices that include a substrate comprising an array of carbon nanotubes (CNTs) to which are chemically attached biological molecules is disclosed. The attached biological molecules are capable of electrical conductivity that is respons... | 10/25/2005 |
| 6957014 | Liquid heater A liquid heater comprising a plurality of storage compartments for containing liquid to be heated. The storage compartments being connected together in series and comprising at least a first end compartment for receiving liquid to be heated and a second end compartm... | 10/18/2005 |
| 6954126 | Lead-less surface mount reed relay A reed relay or reed sensor device that is substantially lead-less and has minimal inductance can be manufactured as an individual unit or as a plurality of units. The reed relay or reed sensor device comprises a substrate that has a plurality contacts on the exteri... | 10/11/2005 |
| 6946273 | Compositions and methods utilizing DNA polymerases The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and/or exhibit reduced discriminatio... | 09/20/2005 |
| 6939982 | Recyclable chiral metathesis catalysts The present invention relates to chiral metal catalysts for stereoselective olefin metathesis reactions, which are recyclable and reusable in such metathesis reactions. The chiral metal-based metathesis catalysts of the invention comprise multidentate optically acti... | 09/06/2005 |
| 6923819 | Apparatus and method for surgical suturing with thread management An apparatus and a method for surgical suturing with thread management. An apparatus for tissue suturing comprising a cartridge having a suturing needle having a pointed end and a blunt end, the suturing needle capable of rotating about an axis; a pusher assembly co... | 08/02/2005 |
| 6921735 | Recyclable metathesis catalysts Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether li... | 07/26/2005 |
| 6913889 | Methods to screen for antibiotic agents and their use in treatment of opportunistic infections The present invention provides novel targets in eukaryotic cells for antibiotic agents and methods for identification of antibiotic agents affecting such targets and the use of the identified antibiotic agents in treatment of opportunistic infections in eukaryotic h... | 07/05/2005 |
| 6911260 | Reinforced carbon nanotubes The present invention relates generally to reinforced carbon nanotubes, and more particularly to reinforced carbon nanotubes having a plurality of microparticulate carbide or oxide materials formed substantially on the surface of such reinforced carbon nanotubes com... | 06/28/2005 |
| 6894035 | Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are pre... | 05/17/2005 |
| 6893819 | Methods for detection of a nucleic acid by sequential amplification The invention relates to a method of detecting a target nucleic acid by linear amplification. The invention also relates to a method of detecting a target nucleic acid by amplification. The method of the invention includes the steps of forming at least a first cleav... | 05/17/2005 |
| 6887365 | Nanotube cantilever probes for nanoscale magnetic microscopy The present invention provides an MFM or MRFM analytical device comprising a micro-dimensional probe that is capable of detecting single proton and single electron spin. Furthermore, it provides an MFM or MRFM device comprising a micro-dimensional probe, that is cap... | 05/03/2005 |
| 6878905 | Apparatus and method for flexible heating cover assembly for thermal cycling of samples of biological material A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element ar... | 04/12/2005 |
| 6866670 | Apparatus for removing plaque from blood vessels using ultrasonic energy A method and apparatus for removing plaque, fatty deposits, and other occlusions from blood vessels using ultrasonic energy. The method and apparatus has particular application in removing plaque from the carotid artery in a non-thermal manner. The apparatus is desi... | 03/15/2005 |
| 6852906 | Assay for measuring enzyme activity in vivo A method is provided for measuring in vivo in a transgenic non-human multicellular organism the activity of a cellular enzyme, which organism is transgenic by virtue of comprising one or more nucleic acid constructs encoding a binding domain and a binding partner th... | 02/08/2005 |
| 6846634 | Method to screen phage display libraries with different ligands The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in a second binding site, which generic ligand is capable of binding fun... | 01/25/2005 |
| 6845328 | Screening methods using the crystal structure of ribosomal protein L11/GTPase activating region rRNA complex The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying comp... | 01/18/2005 |
| 6825330 | Compositions and methods using platinum compounds for nucleic acid labeling The invention relates to novel platinum-based compounds for labeling biomolecules. Platinum based labeling compounds according to the invention irreversibly attach to a target biomolecule via coordination of a platinum (II) metal center with N or S atoms on the targ... | 11/30/2004 |
| 6807885 | Torque limiting wrench for an ultrasonic medical device The present invention provides an apparatus and method for a torque limiting wrench used for applying a torque to a medical device to prevent damage to the medical device by providing a predetermined torque limit to indicate when the predetermined torque is reached.... | 10/26/2004 |
| 6808882 | Optical sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their r... | 10/26/2004 |
| 6802835 | Apparatus and method for using a steerable catheter device A handle includes a body portion and a handle portion which is slidably and rotatably mounted on the body portion. Shoulders on the body portion and the handle portion limit relative sliding movement of the body portion and handle portion. A catheter open at both en... | 10/12/2004 |
| 6803216 | Compositions and methods for random nucleic acid mutagenesis The invention relates to compositions and methods for nucleic acid PCR mutagenesis using novel error-prone DNA polymerases and a PCR enhancing factor. The invention also relates to compositions and methods for nucleic mutagenesis with two or more DNA polymerases lac... | 10/12/2004 |
| 6773705 | Methods for diagnosing and treating autoimmune disease The invention provides a method of detecting autoimmune disease in a mammal, comprising providing a biological sample from a mammal and detecting proteasome activity, wherein a reduction in proteasome activity from a basal state is indicative of autoimmune disease. ... | 08/10/2004 |
| 6737406 | Cryptic peptides and method for their identification The present invention relates to immunologically cryptic peptides; methods for their identification in individuals and populations and their use in diagnosis and therapy of pathological conditions such as asthma and allergy, and their use in screening for therapeuti... | 05/18/2004 |
| 6733451 | Apparatus and method for an ultrasonic probe used with a pharmacological agent The present invention provides an apparatus and a method of using an ultrasonic probe with a pharmacological agent to enhance an occlusion treating effect of the ultrasonic probe to effectively remove an occlusion. The pharmacological agent is released through a cat... | 05/11/2004 |
| 6730496 | Method of detecting first generation environmental-sourced microbes in an environmentally-derived sample The invention relates to a method of detecting the presence or absence of a target microbe in a liquid sample, the method comprising: providing a powdered medium having one or more nutrient indicators and ingredients to support the growth of the target microbe, the ... | 05/04/2004 |
| 6730048 | Apparatus and method for ultrasonic medical device with improved visibility in imaging procedures The present invention provides an apparatus and method for an ultrasonic medical device with improved visibility in imaging procedures. A medical device comprises an elongated probe having a material of high radiopacity at an at least one predetermined location of t... | 05/04/2004 |
| 6730883 | Flexible heating cover assembly for thermal cycling of samples of biological material A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element ar... | 05/04/2004 |
| 6728352 | Switch interaction subsystems for facilitating network information management A network information management system includes, among other elements, a traffic reporting system, a switch shell, and a scheduling mechanism. The traffic reporting includes a database which holds traffic-related data collected from a network switch. The switch she... | 04/27/2004 |
| 6728436 | Optical signal modulation method and optical signal transmission system for high speed transmission system The invention relates to an optical signal transmission system with phase modulation and the implementation method. The system adds a phase modulator in the optical signal-emitting module. The optical pulses after intensity modulation and a high-speed data stream ar... | 04/27/2004 |
| 6724839 | Adaptive inter-symbol interference boost equalization apparatus and method An apparatus mitigates inter-symbol interference effects on an oscillating signal from which digital data will be obtained at a receive end of a channel. The inter-symbol interference is introduced into the oscillating signal as a result of transmitting the oscillat... | 04/20/2004 |
| 6717759 | Hindering PTP in a hard disk A hard disk is provided with tools for limiting the duty cycle (a group of variations of load with time). The write current is controlled by, e.g., limiting the duration of a given write cycle. The write cycle may involve writing data continuously along adjacent por... | 04/06/2004 |
