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| Number | Title | Issue Date |
| RE40211 | Diazodisulfones wherein R1 is a C3-8 branched or cyclic alkyl group, and R2 is a C1-8 straight-chain, branched or cyclic alkyl group, is effective as a photoacid generator when used in a photoresist ma... | 04/01/2008 |
| 7101992 | Nucleic acid base pair A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static repulsion and a stacking effect) and can be recognized by a polymerase ... | 09/05/2006 |
| 7101969 | Compositions and methods involving an essential gene and its encoded protein This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylo... | 09/05/2006 |
| 7083932 | Nucleic acid molecules encoding peptides having pronociceptive properties The present invention is related to nucleic acid molecules, the peptides encoded by said nucleic acid moleucles and the inhibitors direacted against said nucleic acid molecules or said peptides. The present invention concerns also the pharmaceutical composition, the... | 08/01/2006 |
| 6998472 | Obesity gene The invention describes a previously unknown gene, termed 5′OT-EST, which is responsible for inducing an obesity and/or infertility phenotype in transgenic animals, and transgenic animals comprising mutants of 5′OT-EST which are useful for assaying compounds for... | 02/14/2006 |
| 6994737 | High-capacity polymeric Li-ion cell and its production method This invention is related to a process for preparing polymeric Li-ion cell with high-capacity as well as the cells manufactured with the process. The process produces anode paste with lithium salt and cobalt oxide and sprays the paste onto aluminum current collector... | 02/07/2006 |
| 6992772 | Method and apparatus for optical sampling to reduce interfering variances The present invention relates to a method and apparatus of that utilizes a reflective enclosure to simulate optical homogeneity in an otherwise inhomogeneous sample. The illumination sources and sample are placed within the reflective enclosure, thus providing a met... | 01/31/2006 |
| 6982321 | Altered antibodies An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequence for producing the... | 01/03/2006 |
| 6977164 | Compositions and kits for Herpes Simplex Virus type 1 and 2 nucleic acid detection The invention relates to polynucleotides for HSV detection and the use of these polypeptides in kits and methods for HSV detection. ... | 12/20/2005 |
| 6962821 | Thermal cycler including a temperature gradient block A method in which a temperature gradient is generated across a “gradient” block, and an apparatus comprising a block across which a temperature gradient can be generated. By setting up such a gradient, multiple reaction mixtures held in wells on the gradient blo... | 11/08/2005 |
| 6963021 | Chimeric expression promoters originating from commelina yellow mottle virus and cassava vein mosaic virus The present invention relates to a chimeric expression promoter comprising at least one nucleic acid sequence derived from a first plant promoter containing a plant vascular expression promoter region, where the plant vascular expression promoter region is replaced ... | 11/08/2005 |
| 6960592 | 1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one compound for the treatment of impotence The present invention relates to new 1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one compounds of formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, useful for treatment of impotence diseases: ... | 11/01/2005 |
| 6958390 | Compositions and kits for herpes simplex virus type 1 and 2 nucleic acid detection The invention relates to polynucleotides for HSV detection and the use of these polypeptides in kits and methods for HSV detection. ... | 10/25/2005 |
| 6946244 | Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13) The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO.1 as well as to a drug screening method and kit ... | 09/20/2005 |
| 6936452 | Inhibitors of the inositol polyphosphate 5-phosphate SHIP2 molecule The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical compositi... | 08/30/2005 |
| 6936428 | Dimeric flourescent polypeptides The invention relates to proteins or polypeptides that comprise intramolecular dimers of fluorescent protein monomers. More specifically, the invention relates to recombinant polypeptides comprising a monomer of a fluorescent polypeptide, a linker peptide, and a sec... | 08/30/2005 |
| 6930174 | CCR5 chemokine receptor-specific antibodies A peptide has an amino acid sequence having more than 80% homology with the amino acid sequence listed as SEQ ID NO:4. A nucleic acid molecule has more than 80% homology with one of the nucleic acid sequences listed as SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3. Ligan... | 08/16/2005 |
| 6925394 | Crystal structure of the 30s ribosome The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 with unit cell dimensions of a=401.4±4.0 Å, b=401.4±4.0 Å, c=175.9±5.0 ... | 08/02/2005 |
| 6923959 | Method of pre-inducing a state of immune tolerance before organ transplantation Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing be... | 08/02/2005 |
| 6916619 | Compositions and methods for genetic analysis of polycystic kidney disease The subject invention relates to methods for detection of mutations in a PKD gene using DHPLC. The invention includes the following aspects: identification of PKD unique sites; design of PKD-specific primers; amplification of PKD-specific products; and analysis of P... | 07/12/2005 |
| 6914052 | Selective anti-viral nucleoside chain terminators The present invention relates to dideoxynucleoside analog compounds containing a dideoxy ribofuranosyl moiety that exhibit selective anti-viral activity coupled with substantially low toxicity toward the host cells. In particular, the compounds according to the pres... | 07/05/2005 |
| 6906179 | Antibody to SNIP1 The invention provides novel compositions comprising a Smad protein and an isolated protein component of the proteasome-mediated degradation pathway. The invention also provides novel compositions comprising a Smad1 protein and a substrate for proteasome-mediated de... | 06/14/2005 |
| 6903073 | Methods to stimulate insulin production by pancreatic beta-cells The invention features a method of treating deficiency of insulin in a patient, comprising administering to a patient in need thereof hedgehog protein or nucleic acid in an amount effective to raise the level of insulin in the patient. ... | 06/07/2005 |
| 6890750 | Composition and methods utilizing stable reporter cell lines for detection of chop-dependent signal transduction The invention encompasses compositions and methods which utilize a cell line comprising a stably integrated recombinant nucleic acid construct comprising: a reporter gene operably linked to a recognition sequence for a sequence-specific DNA-binding protein; and a st... | 05/10/2005 |
| 6884620 | Humanized polynucleotide sequence encoding Renilla mulleri green fluorescent protein The present invention provides a polynucleotide encoding a green fluorescent protein from Renilla mulleri comprising a humanized sequence which permits enhanced expression of the encoded polypeptide in mammalian cells. ... | 04/26/2005 |
| 6881751 | Medicament containing platinum complex compounds and the use thereof The present invention relates to a pharmaceutical preparation containing at least one compound of general formula (I) wherein R1 and R2 are each independently of each other a straight-chain or bra... | 04/19/2005 |
| 6872538 | High-throughput screening diagnostic and/or dosage method of an agonist and/or an antagonist for a calcium-coupled receptor The present invention is related to a diagnostic an/or dosage method of an agonist and/or an antagonist and/or a modulator for a calcium-coupled receptor and/or channel and/or any other calcium-coupled protein, comprising the following successive steps: disposing th... | 03/29/2005 |
| 6866843 | Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing be... | 03/15/2005 |
| 6864224 | Kinase inhibitors and methods of use in screening assays and modulation of cell proliferation and growth The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathwa... | 03/08/2005 |
| 6858393 | Chain terminators for DNA synthesis The invention relates to acyclic chain terminator nucleotide analogs. More particularly, the invention relates to phosphonomethoxyethyl nucleotide analogs and detectably labeled versions thereof, especially fluorescently labeled versions thereof. The invention furth... | 02/22/2005 |
| 6852691 | Anti-angiogenic peptides and methods of use thereof EM 1, a novel anti-angiogenic protein, and a deletion mutant of endostatin, is described, as well as methods of making EM1, therapeutic compositions comprising EM1, and methods for using those compositions. ... | 02/08/2005 |
| 6841357 | Method and kits for titering adeno-associated virus vectors A method of titering adeno-associated virus particles in a sample, said method comprising the steps of contacting target cells with a DNA synthesis inhibitor and an agent that increases the activity of the CMV immediate early promoter; contacting target cells treate... | 01/11/2005 |
| 6828106 | Methods and compositions using coiled binding partners The present invention relates to a polypeptide multimer comprising a first polypeptide having associated therewith a label and a second polypeptide, wherein a) at least one of the polypeptides is susceptible to protease digestion; b) association of the polypeptides ... | 12/07/2004 |
| 6809085 | Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use The present invention relates to drug delivery devices for moist tissue, in particular mucosal tissue and tissue in the serous cavities, as well as a method of its use. The devices, which contain NOCC, are adherent to the mucosal tissue, allowing localized drug deli... | 10/26/2004 |
| 6808874 | Methods of monitoring enzyme activity We describe a method for monitoring the activity of an enzyme, the method comprising the steps of: providing a binding domain which includes a site for enzymatic modification; providing a binding partner which binds to the binding domain in a manner which is depende... | 10/26/2004 |
| 6803201 | Compositions and methods for polynucleotide sequence determination The present invention relates to a method for identifying a nucleotide at a predetermined location on a target polynucleotide. The method involves single nucleotide extension reaction comprising an oligonucleotide primer comprising a first sequence and a second sequ... | 10/12/2004 |
| 6800447 | Methods for identifying compounds which bind the active CCR5 chemokine receptor A peptide has an amino acid sequence having more than 80% homology with the amino acid sequence listed as SEQ ID NO:4. A nucleic acid molecule has more than 80% homology with one of the nucleic sequences listed as SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3. Ligands, a... | 10/05/2004 |
| 6801316 | Measurement of an analyte concentration in a scattering medium A non-invasive detection method for glucose and other constituents of interest in a sample is described. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing the spectroph... | 10/05/2004 |
| 6797488 | Methods of producing anti-angiogenic proteins Methods for making proteins with anti-angiogenic properties are disclosed. The system used is a yeast expression system which produces biologically active proteins at high titer. ... | 09/28/2004 |
| 6790626 | Human pyrimidine receptor The present invention concerns a new receptor having a preference for pyrimidine nucleotides, preferably UTP, or purine nucleotides and UDP, and which has an amino acid sequence having more than 60% homology with the amino acid sequence shown in FIG. 1. ... | 09/14/2004 |
